Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
11 Cards in this Set
- Front
- Back
|
11.1
syngeneic graft (isograft) |
- genetically identical eg. monozygotic twin, within inbred mouse strain
|
|
|
11.2
allogeneic graft |
- genetically different, same species
- related - blood relatives share some genes through descent - unrelated |
|
|
11.3
xenograft |
different species
|
|
|
11.4
allorecognition |
- immune recognition of differences b/w members of the same species (alloantigens)
|
|
|
11.5
First set rejection |
- revascularization: days 3-7
- cellular infiltrate: days 7-10 - necrotic tissues, damaged blood vessels, blood clotsL days 10-14 |
|
|
11.6
second set rejection |
- sensitized through prior transplant or transfusion or pregnancy
- may lead to reduced graft survival and /or hyperacute rejection |
|
|
11.7
MHC and Ag restriction |
- a single TCR can see self MHC + foreign peptide or foreign MHC + some peptide
|
|
|
11.8
recognition of foreign MHC molecules 1) direct cellular recognition |
- donor APC expressing donor MHC interact w/ recipient T cells
|
|
|
11.9
recognition of foreign MHC molecules 2) indirect cellular recognition |
- recipient APC presents fragments of foreign HLA proteins to recipient T cells
|
|
|
11.10
minor histocompatibility antigens: |
- polymorphic proteins other than HLA can stimulate allorecognition
- slow rate of rejection |
|
|
11.11
suppress immune response |
- inhibit mitosis
- anti-inflammatory agents - interfere with immune cell activation - T/B cell depletion |
