Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
15 Cards in this Set
- Front
- Back
What is a bioisostere?
|
A compound resulting from the exchange of an atom with another similar atom or group of atoms.
The objective is to create a new compound with similar biological properties to the parent compound. |
|
What are isosteres?
|
A compound resulting from the exchange of an atom with another similar atom or group of atoms.
-similar physical and chemical properties molecules or ions of similar size containing the same number of atoms and valence electrons (ex: O2-, F-, Ne) |
|
What are stereoisomers?
|
isomers whose molecules have the same atoms bonded to each other but differ in the way these atoms are arranged in space.
|
|
What are the three types of stereoisomers?
|
1. Geometric (cis/trans) isomers
2. Optical Isomers 3. Constitutional Isomers |
|
What are enatiomers?
|
-optical isomers
-mirror images of each other -not identical -have 1 or more chiral carbons -rotate the plane of polarized light equally, but in opposite directions -same physical properties -same chemical properties (A type of optical isomer) |
|
What are geometric (cis-trans) isomers?
|
-same molecular formula
-different geometric configuration (atoms are attached in different spatial arrangements on either side of a double bond) |
|
"MJ pose"
|
Trans isomer
|
|
What are the two types of optical isomers?
|
-enatiomers
-diastereomers |
|
What are the two types of geometrical isomers?
|
-cis
-trans |
|
Define Isomers
|
molecules of identical atomic compositions (molecular formulas), but with different bonding arrangements of atoms or orientation of their atoms in space.
(optical, geometric and conformational isomerism) |
|
Define Optical Isomers
|
molecules with the same atomic composition but different bonding arrangements between atoms.
-same molecular formula -different bonding arrangements -distinct chemical entities -different chemical and physical properties |
|
Define Steroisomers
|
-Identical molecular formula
-Identical bonding arrangement -different orientations of atoms in space -different orientations cannot interconvert freely by bond rotation. -differ only in relative spatial orientations of atoms -Three Types: optical, geometric, conformational |
|
Define Conformational Isomers
|
-Stereoisomers
-different relative spatial arrangements of atoms -rotation about sigma bonds -aka Rotamers |
|
What is another name for conformational isomers?
|
Rotamers
|
|
What are diastereomers?
|
-optical isomers
-NOT mirror images -at least two chiral carbons -sterochemistry of one chiral carbon will be the same -DIFFERENT physical and chemical properties -split light in different directions |