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8 Cards in this Set

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What is the formula for the partition coefficient?
P = [drug] <--organic
-----------------
[drug] <--aqueous
T/F: Most drugs have a partition coeffeicient
True
Define Partition coefficient
A measure of the drugs lipid and water solubility (balanced in most drugs)
__________ is determine by charges (polarity).

(hydrophilicity, hydrophobicity, lipophilicity or lipophobicity?)
hydrophilicity
What are the main two things that effect water solubility?
-H bonding capacity
-Ionic character
Compounds with what two atoms have increased solubility?
Nitrogen and Oxygen
_______________ is increased by non-ionizable groups, hydrocarbon chains and ring systems.

(hydrophilicity, hydrophobicity, lipophilicity or lipophobicity?)
Lipophilicity
List side groups that can increase lipophilicity.
-Non-ionizable groups
-Hydrocarbon chains
-Ring systems (ex:benzyne)