Stereochemistry conformation is how molecules are orientated in space. There are two basic types of isomers: constitutional or stereoisomers. Constitutional isomers gave the same molecular formula but different connectivity, while stereoisomers have the same connectivity but a different orientation in space. Stereoisomer has two subunits called enantiomers and diastereomers. Enantiomers are molecules that are mirror images, while diastereomers are not mirror images. Stereochemistry focus mainly on chiral centers, which is a carbon with four different substituents attached to it.
Though there are different types of nuclear magnetic resonance (NMR) such a proton and carbon, this experiment focus on phosphorous NMR which gives a wider spectral …show more content…
This experiment worked in the sense that the racemic mixture produced four different products, while the optically pure (R) and (S) only produced one product, or two enantiomers. If the P NMR experiment was performed using the crude reaction mixture of the phosphonate compound without purification then some of the reactants might still be present on the solution and can give different readings since one of the reagents used was phosphorous trichloride. Since enantiomers give of the same peaks in an NMR we would observe only one peak present, represented by the optically pure (R) and (S) NMR. The stereochemistry relationship between 1A and 1D is that they are enantiomers. 1B and 1C are enantiomers as well. 1B and 1A are diastereomers as well as 1B and 1D. 1C and 1A are diastereomers and well as 1C and 1D. Overall this experiment ran rather smoothly, although there was some difficulty in obtaining the small amounts required through the needle of the syringe but after a couple of tries the problem was overcome. Some basic fundamental principles demonstrated in the results are understanding the configuration of chiral molecules. Also, a better understanding of the 3-Dimensional shape of these molecules is achieved. After this experiment we had a better comprehension of how NMR graphs tend to look and that only one peak is given off for enantiomers because they give of the same magnetic resonance. In the reaction below the mechanism starts with a nucleophilic attack from the alcohol, in this case sec-phenethylalcohol, to the PCl3 causing a chlorine atom to leave. The nitrogen from dimethylaniline grabs the hydrogen from the alcohol that’s attached to the phosphate and the electrons from the O-H are transferred to oxygen. Then another molecule of the alcohol attacks the phosphate one again cleaving the P-Cl bond. Then another molecule of
Though there are different types of nuclear magnetic resonance (NMR) such a proton and carbon, this experiment focus on phosphorous NMR which gives a wider spectral …show more content…
This experiment worked in the sense that the racemic mixture produced four different products, while the optically pure (R) and (S) only produced one product, or two enantiomers. If the P NMR experiment was performed using the crude reaction mixture of the phosphonate compound without purification then some of the reactants might still be present on the solution and can give different readings since one of the reagents used was phosphorous trichloride. Since enantiomers give of the same peaks in an NMR we would observe only one peak present, represented by the optically pure (R) and (S) NMR. The stereochemistry relationship between 1A and 1D is that they are enantiomers. 1B and 1C are enantiomers as well. 1B and 1A are diastereomers as well as 1B and 1D. 1C and 1A are diastereomers and well as 1C and 1D. Overall this experiment ran rather smoothly, although there was some difficulty in obtaining the small amounts required through the needle of the syringe but after a couple of tries the problem was overcome. Some basic fundamental principles demonstrated in the results are understanding the configuration of chiral molecules. Also, a better understanding of the 3-Dimensional shape of these molecules is achieved. After this experiment we had a better comprehension of how NMR graphs tend to look and that only one peak is given off for enantiomers because they give of the same magnetic resonance. In the reaction below the mechanism starts with a nucleophilic attack from the alcohol, in this case sec-phenethylalcohol, to the PCl3 causing a chlorine atom to leave. The nitrogen from dimethylaniline grabs the hydrogen from the alcohol that’s attached to the phosphate and the electrons from the O-H are transferred to oxygen. Then another molecule of the alcohol attacks the phosphate one again cleaving the P-Cl bond. Then another molecule of