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100 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Which of these special hematology test require a defribrinated specimen? |
OHA Osmotic fragility test autoHemolysis test Acidified serum test |
OHA |
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A blood pressure cuff should be applied to the arm and inflated to ______ for the duration of a template bleeding time test. |
40mmHg |
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Which of these EDTA concentrations is recomended for complete anticoagulation without cellular alteration. |
1.5mg/ml |
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High molecular weight kinninogen is also known as |
Fitzgerald factor |
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The activated partial thromboplastin time (APTT) is used as a screen for the laboratory evaluation of inherited or acquired deficiencies in the: |
Intrinsic pathway of coagulation cascade |
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Based on the following data, what is the most likely factor deficiency? PT NORMAL APTT PROLONGED APTT +NORMAL PLASMA CORRECTION APTT +ADSORBED PLASMA NO CORRECTION APTT + AGED SERUM CORRECTION |
FACTOR IX |
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The earliest recognizable erythroid precursor on a wright stain smear of the bone marrow is? |
Pronormoblast |
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Immature erythrocyte found in the bone marrow with the following characteristics: 12-17um in diameter N:C of 4:1 nucleoli not usually apparent basophilic cytoplasm |
Prorubricyte (basophilic normoblast) |
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Increase amount of 2,3-DPG ____ the oxygen affinity of the hemoglobin molecule. |
Decrease |
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One to five dacryocyte seen per oil immersion objective |
1+ |
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Eleven to twenty stomatocytes seen per oil immersion field |
Positive |
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One to two sickle cells seen per oil immersion field |
Positive |
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Six to seven howel red cells with howell jolly bodies seen per oil immersion field |
Positive |
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twelve to thirtheen thorn cells see per oil immersion objective |
3+ |
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In hypochromia grading, 2+ corresponds to |
Area of pallor is two-thirds of cell diameter |
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WBC COUNT FORMULA |
wbc count = (# of cells x dilutions) ÷ (area of squres counted x depth) |
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Type of Pelger Huet Anomaly usually seen at what state? |
Heterozygous |
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Describes the morphology of Pelger Huet Anomaly |
Pince nez appearance |
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Hematocrit capillary tube after centrifugation. RBC is the? |
Fourth Layer |
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MPO (+) 1. neutrophil 2. eosinophil 3. basophil 4. RBC |
1 and 2 |
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How many WBCs should be counted when lymphocytes counted is greater than neutrophil? |
200 |
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Action/s done by laser flow cytometry 1 cell count 2 Granularity 3 Surface Antigen |
1 2 and 3 |
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Platelet estimate of 400,00/uL |
Normal |
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Platelet estimate of 150,000/uL |
Normal |
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Grade of rouleaux of 3-5% |
slightly high |
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Hematocrit capillary tube after centrifugation. The first layer is |
Fatty Layer |
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What is Normal MCH? |
27-32pg |
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Hematopoiesis that does not occur in the bone marrow is known as extramedullary hematopoiesis. What organ is responsible for this? |
Liver |
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What is the screening test for paroxysmal nocturnal hemoglobinuria (PNH) ? |
Sugar Water Test Sucrose Hemolysis test |
Double S |
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What cell in WBC stage series has a kidney bean-shape nucleus? |
metamyelocytes |
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what are being measured in 3 part differential automated instrument? |
Lymphocytes, Monocytes, Granulocytes |
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Abnormal cells seen Hodg'kins lymphoma. |
Reed-Sternberg cell ( Owls eye inclusion ) |
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CD marker for NK cells |
CD 16 and CD56 |
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CD MARKER FOR IMMATURE T CELL |
CD2 |
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CD MARKER FOR T HELPER CELLS |
CD 4 |
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CD MARKER FOR STEMCELLS |
CD34 |
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Stage in megakaryocytic series where thrombocytes are already visible. |
Metamegakaryocyte |
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Coagulation Factors that are member of the contact group. |
XII XI Pre-Kallikren HMWK (High Molecular Weight Kininogen) |
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Coagulation factors that are member of the prothrimbin group/ vit K dependent group |
X IX VII II |
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It is a screening procedure for the measurement of fibrinolytic activity |
Euglobin Clot lysis test |
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What is the error caused by the increased number of schistocytes in a whole blood specimen? |
Makes accurate RBC and platelet count impossible |
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Macrocytic RBCs/hpf is 25-50% graded as: |
2+ |
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A 50 year old woman eho has been receiving bulsufan for 3 years for chronic myelogenous leukemia becomes anemic. |
Many peroxidase-negative blast cells in the peripheral blood |
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Lack of vitamin B12 or folic acid hinders the erythroblast in manufacturing |
DNA |
Megaloblastic Anemia |
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A decreased osmotic fragility test would be associated with which of the following conditions? sickle cell anemia hereditary spherocytosis HDN Aquired hemolytic anemia |
Sickle cell anemia hereditary spherocytosis = increased OFT |
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The recommend type of microscopy for the performance of manual platelet count is? |
Phase contrast microscope |
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To evaluate normal platelet numbers in an appropriate are of blood smear, approximately how many platelets, should be observed per oil immersion field? |
8-20 (7-21) if platelet estimate times by 20,000 |
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A patient has a history of mild hemorrhagic episodes. Laboratory results include a prolonged prothrombin time and activated partial thromboplastin time. The abnormal prothrombin time was corrected by normal ad adsorbed plasma, but not aged serum. Which of the following coagulation factors is deficient? |
Factor V |
Common pathway 1 2 5 8 13 |
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The Abnormal APTT seen in pathological criculating anticoagulant is Corrected with aged serum Corrected with adsorbed plasma Corrected with normal plasma Not corrected with any of the above |
Not corrected with any of the above |
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Counting method of WBCs counted in consecutive fields as the blood film is moved from side to side |
Crenellation |
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A schistocyte with one or more hornlikr projections has been identified as a? |
Helmet cell |
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The D dimer test is positive in DIC as soon as ______ after onset |
4 hours 4-24 hours fibrinogen decreased 48 hours platelet count decreased |
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What is the ratio of iron to porphyrin and heme? |
1:1 |
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Hemoglobin C disease is characterized by |
Rod shape crystals Hb SC protruding washington monument crystals |
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The Kleinhauer technique is used to differentiate |
Hb-A2 from Hb-F |
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Parasites in the red blood cells are best demonstrated with which stain? |
Geimsa |
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Erythrocytes with a diameter of 9-12 microns are referred to as? |
Macrocyte |
Normal size 6-8 um |
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5M urea or 1% monochloracetic acid are reagents used in tests for which plasma factor deficiency |
XIII |
Duckert's test |
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Storage pool deficiency and Wiskott Aldrich are qualitative platelet disorders that have Abnormal : |
Secondary aggregation |
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Ehlers Danlos, Von Willebrand and Bernard Soulier are all qualitative platelet disorders that have abnormalities of : |
Adhesion |
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At what stage will specific (secondary granules) of granulocytes appear? |
Myelocyte Primary granules= promyelocyte |
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Examples of microcytic, hypochromic anemias |
Thalassemia Anemia of chronic infection Iron deficiency anemia Lead Poisoning Sideroblastic anemia |
TAILS |
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Plasma cells evolve from which cell line? |
Lymphocytic (B-lymphocyte) |
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Prolonged PT and APTT test that are corrected by age serum but not absored plasma suggest a deficiency of which of the following coagulation factors? |
X |
COMMON PATHWAY ALWAYS FIND IN UNCORRECTED |
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Which of the following disease is associated with a positive Tdt and PAS stain? |
ALL ( Acute Lymphocytic Leukemia) |
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Prolonged bleeding time and giant platelets best describes. |
Bernard-Soulier syndrome |
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Suspect in afribinogenemia |
Bleeding time abnormal Reptilase time abnormal thrombin time abnormal |
Zero level of fibrinogen |
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A 22 year old female was seen in the emergency room with evidence of prolonged vleeding following a spider bite. Lab results show: Blood smear: shistocytes Platelet count: 50,000/mm³ PT : 20 secs APTT: 60 secs D-dimer : positive most likely diagnosis is: |
Secondary fibrinolysis |
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Nucleated RBC s are most likely to be seen in the peripheral blood of which of these beta thalassemias? Beta thalassemia minima Beta thalassemia minor Beta thalassemia intermedia Beta thalassemia major |
Beta thalassemia major |
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The mediator cells that bind MOST IgE antibodies are? |
Bashophils |
IgE - Allergy |
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What would be a PROBABLE diagnosis for a habitual alcoholic with slight elevations in the PT and APTT test? |
Liver disease |
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The beta hemoglobin loci are found on which chromosome? |
Chromosome 11 |
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Which of the following is not primarily a hemolytic process? erythroblastosis fetalis mononucleosis brown spider bite plasmodium infection |
mononucleosis |
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The absence of which clotting factor cause NO bleeding tendency? |
Hageman Factor ( XII ) |
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Which of the following Laboratory results would be seen in a patient with acute disseminated intravascular coagulation (DIC)? |
Prolonged PT Decrease fibrinogen Decreased Platelet count Increased FDP |
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Falsely decreased ESR: |
Delay in processing for ESR |
FALSELY increase mechanical vibration tilting of tube increase temperature |
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Function of ADAMTS13 enzyme? |
Cleaving ultra large molecules of von willebrand factor to keep them out of the circulation |
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Which of these method could be used to differentiate between Howell-Jolly Bodies and Pappenheimer bodies and what results would be noted? |
Prussian Blue stain: Pappenheimer bodies stain blue but Howell-Jolly bodies do not stain blue |
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Which hemoglobin cannot bind oxygen? |
Methemoglobin ( feric form of iron ) |
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Methemoglobin is an abnormal hemoglobin that contains? |
Ferric iron |
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The counting of blood cells on the coulter counter (coulter electronics) is based on what principle? |
Saline conducts electricity better than cells do |
Electrical impedence- may na count pag nag stop electricity |
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Burr cells and thorn cells represent what abnormality of red cell? |
Damage to the red cell membrane |
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Philadelphia chromosome is associated with |
Chronic Granulocytic Leukemia |
M3 |
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Stage 1 of coagulation involves the formation of |
Prothrombinase |
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Stage II of coagulation involves the formation of |
Thrombin |
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A normal bleeding time by Ivy method falls in what range ? |
1-6 minutes |
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Parahemophilia is due to a deficiency of factor |
Factor V common= factor VIII rare = factor II Hemophilia = factor IX |
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What marrow cells may be confused with plasma cells as they both tend to have eccentric nuclei and basophilic cytoplasm? |
Osteoblasts Osteoclast - Megakaryocyte |
Baliktad na b |
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What is the immediate precursor of the reticulocyte? |
Orthochromic normoblast |
Pro-Baso-Poly-Ortho- rectic |
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In Ivy method, the blood pressure cuff is inflated to: |
40mmHg |
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Smudged cell is observed in: |
Chronic lymphocytic leukemia |
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Also known as the Natural anticoagulant |
Heparin |
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What erythrocytic pathway provides the majority of the energy needed by the RBCs? |
Embden Meyerhof |
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Most common problem in cell counting |
Aperture Plugs |
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It is defined as the expectation of blood secondary to hemorrhage in the larynx, trachea, bronchi, or lungs |
Hemoptysis |
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In a factor X deficiency, a prolonged PT or APTT is corrected by the addition of: I. Aged Plasma II. Aged Serum III. Fresh serum IV. Adsorbed plasma |
1 2 and 3 |
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Mean cell volume (MCV) is calculated using the following formula: |
(Hct ÷ RBC)×10 |
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"Bite cells" are usually seen in patients with : |
G6PD deficiency = Heinz body |
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Iron deficiency anemia may be distinguished from anemia of chronic infection by: |
Total iron binding capacity |
IDA - Increased ACD - Decreased |
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The macrocyte typically seen in megaloblastic processes are: |
Ovalocytic Non-megaloblastic = round |
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