a. Explain why the PTT is abnormal and the PT is normal?
• Hemophilia is a disorder that results in prolonged PTT. Partial thromboplastin time (PTT) is a measure of a time that is required by plasma to form a clot when it comes in contact with agents which activates the contact factors. PTT assesses intrinsic and common pathway of coagulation. Prothrombin time ( PT) measures the time needed for plasma to form a clot in the presence of tissue factor. PT evaluates extrinsic and common pathway of coagulation (Zehnder, 2017). In Hemophilia, the deficient factors are related to the intrinsic cascade of coagulation, therefore PTT is prolonged and abnormal.
b. In which gender is this disorder common and why?
• This disorder is common in male since it is sex (X) linked recessive disorder. The male acquires the disease when the male carries one defective copy of to X chromosome. Female are usually carriers since the female has one normal allele that compensates for the diseased allele (Hoots & Shapiro, 2017 ).
c. How do the clinical manifestations in a patient …show more content…
The patient with platelet dysfunction also may present with petechiae (small capillary hemorrhage), ecchymoses (small purple, multiple superficial lesions), purpura, epistaxis, hematuria, bleeding gums, menorrhagia ( heavy menstrual blood flow) and metrorrhagia ( bleeding between period). On the other hand, a patient with coagulation problem may have delayed bleeding issues. Bleeding from minor trauma or spontaneous bleeding can be persistent. The patient may present with palpable large ecchymoses and large hematomas of deep soft tissues. Bleeding may occur in synovial joints of knees, elbows, and ankles (Drews, 2017). According to Yee, if the patient has coagulation issue, they tend to bleed into muscle, soft tissue and joints whereas skin and mucous membrane bleeding suggest the problem with platelet abnormalities
• Hemophilia is a disorder that results in prolonged PTT. Partial thromboplastin time (PTT) is a measure of a time that is required by plasma to form a clot when it comes in contact with agents which activates the contact factors. PTT assesses intrinsic and common pathway of coagulation. Prothrombin time ( PT) measures the time needed for plasma to form a clot in the presence of tissue factor. PT evaluates extrinsic and common pathway of coagulation (Zehnder, 2017). In Hemophilia, the deficient factors are related to the intrinsic cascade of coagulation, therefore PTT is prolonged and abnormal.
b. In which gender is this disorder common and why?
• This disorder is common in male since it is sex (X) linked recessive disorder. The male acquires the disease when the male carries one defective copy of to X chromosome. Female are usually carriers since the female has one normal allele that compensates for the diseased allele (Hoots & Shapiro, 2017 ).
c. How do the clinical manifestations in a patient …show more content…
The patient with platelet dysfunction also may present with petechiae (small capillary hemorrhage), ecchymoses (small purple, multiple superficial lesions), purpura, epistaxis, hematuria, bleeding gums, menorrhagia ( heavy menstrual blood flow) and metrorrhagia ( bleeding between period). On the other hand, a patient with coagulation problem may have delayed bleeding issues. Bleeding from minor trauma or spontaneous bleeding can be persistent. The patient may present with palpable large ecchymoses and large hematomas of deep soft tissues. Bleeding may occur in synovial joints of knees, elbows, and ankles (Drews, 2017). According to Yee, if the patient has coagulation issue, they tend to bleed into muscle, soft tissue and joints whereas skin and mucous membrane bleeding suggest the problem with platelet abnormalities