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16 Cards in this Set

  • Front
  • Back
apical end of hepatocyte communicates with...
contents in canaliculi
cellular & paracellular transportation of water
bicarb (micelle formation, neutralize stomache acid, increase sol of bile acid & salt)
transport in bile secretion
Na/K ATPase (side, Na out)
draws Na in from sinus
bile salt follows
combines with protein
ATPase pumps into canaliculus
control gate for secretion of bile
sphincter of Oddi
components of bile
Bile salts- 65%
Phospholipids (20%)
-lecithin (phosphotidyl choline)
transporters in bile concentration
in gallbladder
Na/K pump (side) drives Na out (to interstitium)
Na in from lumen (H+ out)
Cl follows & draws water from lumen to interstit via tight jctn
Cl/HCO3 at lumen (Cl in)
stimulation of bile release from gallbladder
enteroendocrine sense FA's >8 c's in length
release CCK into blood
binds sm musc cells around Oddi & GB
Oddi relax, GB contract
bile is recycled via...
enterohepatic circulation
2-3 times/meal
only 10-20% excreted/day
bile returned to liver by...
hepatic portal veins
Na dependent R's in terminal ileum
bile acid
derivitive of cholesterol
less soluble than bile salt
has OH
characteristics of bile salt
more completely ionized at neutral pH
more soluble than bile acid
has Glycine or Taurine via peptide bond
formation of bile
7 alpha hydroxylase is rate limit step
7 hydroxychol can become
cholyl CoA
conjugated to glycocholic or taurocholic acid in liver
stability of bile acids
glycocholic acid pKa 3.7
Taurocholic acid pKa 1.5
(more soluble)
function of bile
emulsify fat
increase surface area of lipid for lipase to work on
formation of micelle
bilipid layer
polar group on outside
hydrophobic inside
(happens b/c increased entropy)
unstirred water layer
b/c of micelles
allows polar portion to approach
lipid (nonpolar) held near for absorption