Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
106 Cards in this Set
- Front
- Back
Acanthosis, hyperkeratosis, parakeratosis, neutrophils, hypogranulosis
|
Psoriasis
|
|
Sebum, follicular infundibulum, lymphocytic infiltrate
|
Acne vulgaris
|
|
Wickham's striae
|
Lichen planus
|
|
Association with hepatitis C
|
Lichen planus
|
|
Band-like infiltrate of lymphocytes and histiocytes at dermal-epidermal junction
|
Lichen planus
|
|
Acanthosis with saw-toothing
|
Lichen planus
|
|
Wedge-shaped hypergranulosis, hyperkeratosis (without parakeratosis)
|
Lichen planus
|
|
Prevalent in HIV and Parkinson's disease
|
Seborrheic dermatitis
|
|
Cradle cap
|
Seborrheic dermatitis
|
|
Spongiosis around follicular openings, focal parakeratosis, mild-moderate acanthosis
|
Seborrheic dermatitis
|
|
Possible associations with sebum, Malassezia furfur
|
Seborrheic dermatitis
|
|
Spongiotic dermatitis with variable parakeratosis and acanthosis; eosinophilic infiltrate
|
Atopic dermatitis (eczema)
|
|
Elevated IgE levels
|
Atopic dermatitis (eczema)
|
|
Post-infectious; associated with HSV-1
|
Erythema multiforme minor
|
|
Targetoid lesion on extensor aspects of extremities
|
Erythema multiforme minor
|
|
Usually drug-induced (sulfa drugs, NSAIDs)
|
Erythema multiforme major (Stevens-Johnson syndrome, Toxic Epidermal Necrolysis)
|
|
Interface dermatitis with single necrotic keratinocytes
|
Erythema multiforme major
|
|
Split in lamina lucida of basement membrane on EM
|
Bullous pemphigoid
|
|
Subepidermal blister with no keratinocyte necrosis
|
Bullous pemphigoid
|
|
Linear IgG and C3 deposition along dermal-epidermal junction
|
Bullous pemphigoid
|
|
Positive Nikolsky sign
|
Pemphigus vulgaris
|
|
Autoantibodies against desmoglein III
|
Pemphigus vulgaris
|
|
Acantholysis with suprabasilar split
|
Pemphigus vulgaris
|
|
Tombstoning of basal keratinocytes
|
Pemphigus vulgaris
|
|
IgG and C3 in intercellular staining pattern
|
Pemphigus vulgaris
|
|
Koilocytic changes (intracellular clearing, prominent keratohyaline granules)
|
Verruca vulgaris
|
|
Verrucous epidermal hyperplasia, hyperkeratosis, parakeratosis
|
Verruca vulgaris
|
|
Caused by Poxvirus
|
Molluscum contagiosum
|
|
Cup-like epidermal hyperplasia
|
Molluscum contagiosum
|
|
Epidermal necrosis with inflammation and balloon cells
|
Herpes simplex (HSV-1, HSV-2)
|
|
"Dew drops on rose petals" lesion
|
Varicella (chickenpox)
|
|
Grouped vesicles in dermatomal distribution
|
Zoster (shingles)
|
|
Positive Auspitz sign (punctate bleeding spots upon peeling off of scale)
|
Psoriasis
|
|
Koplik's spots
|
Measles (paramyxovirus)
|
|
Prodrome consisting of cough, coryza, conjunctivitis
|
Measles (paramyxovirus)
|
|
Associated with hydrops fetalis
|
Parvovirus B19 infection (Fifth disease/erythema infectiosum)
|
|
May induce aplastic crisis in individuals with sickle cell disease
|
Parvovirus B19 infection (Fifth disease/erythema infectiosum)
|
|
Cytopathogenic effect with multinucleated giant cells
|
Measles, herpesviruses
|
|
Complications include SSPE, bacterial superinfection, pneumonia, otitis media, croup, encephalitis
|
Measles (paramyxovirus)
|
|
Congenital syndrome results in cataracts, heart defects, neurologic defects
|
Rubella (togavirus)
|
|
Slapped cheek rash
|
Parvovirus B19 infection (Fifth disease/erythema infectiosum)
|
|
Hand-foot-mouth disease
|
Coxsackie virus/enterovirus
|
|
Syncytia formation in culture; hemadsorbing
|
Mumps (paramyxovirus)
|
|
Superficial disease of epidermis; honey-like exudate with black crust
|
Impetigo
|
|
Folliculitis/furuncles
|
Staphylococcus aureus
|
|
Cellulitis related to handling fresh fish
|
Erysipelothrix rhusiopathiae
|
|
Cellulitis related to freshwater exposure
|
Aeromonas hydrophila
|
|
Cellulitis related to ingestion of raw oysters in patients with liver disease
|
Vibrio vulnificus
|
|
Necrotizing fasciitis type II
|
Streptococcus pyogenes (occasionally MRSA)
|
|
Necrotizing fasciitis type I (Fournier's gangrene)
|
Mixed process (anaerobes)
|
|
Gas gangrene
|
Clostridium perfringens
|
|
Well-circumscribed brown macule; basal hyperpigmentation; acanthosis with regular elongation of rete ridges
|
Lentigo simplex
|
|
Flat, deeply pigmented macule; nests of melanocytes at dermal-epidermal junction
|
Junctional melanocytic nevus
|
|
Well-circumscribed raised lesion with epidermal and dermal nests of melanocytes
|
Compound melanocytic nevus
|
|
Polypoid, flesh-colored lesion with dermal melanocyte nests and no epidermal component
|
Intraepidermal melanocytic nevus
|
|
No lateral growth phase; impossible to detect early; large atypical melanocytes invade dermis
|
Nodular melanoma
|
|
Tinea pedis, tinea cruris; anthropophilic dermatophyte
|
Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum
|
|
Tinea capitis; ectothrix; zoophilic
|
Microsporum canis
|
|
Tinea capitis; endothrix; more prevalent in individuals with curly hair; causes diffuse hair loss
|
Trichophyton tonsurans
|
|
Causative agent of tinea versicolor
|
Malassezia furfur
|
|
Spaghetti and meatballs appearance on KOH prep
|
Malassezia furfur
|
|
Intertrigo, diaper rash
|
Candida albicans
|
|
Reservoir = plants, wood
|
Sporothrix schenckii
|
|
Linear nodules spread by lymphatics
|
Sporotrichosis (Sporothrix schenckii)
|
|
Treatment is with potassium iodide (or itraconazole)
|
Sporotrichosis (Sporothrix schenckii)
|
|
Superficial linear burrows; nocturnal pruritus
|
Sarcoptes scabei (mange mite)
|
|
Vector for plague (Yersinia pestis)
|
Fleas (Pulex irritans)
|
|
Wriggling nodules; Central and South America
|
Dermatobia hominis (human botfy)
|
|
Premalignant condition that can evolve into squamous carcinoma in situ
|
Actinic keratosis
|
|
Cutaneous horn
|
Actinic keratosis
|
|
Variable acanthosis, budding of atypical keratinocytes; alternating hyperkeratosis and parakeratosis; solar elastosis
|
Actinic keratosis
|
|
Second most common form of skin cancer
|
Squamous cell carcinoma
|
|
Most common form of skin cancer
|
Basal cell carcinoma
|
|
Peripheral palisading of keratinocytes, mucinous tumor stroma, cleft formation
|
Basal cell carcinoma
|
|
Mutations in patched gene
|
Basal cell carcinoma
|
|
T cell (CD4) lymphoma of skin
|
Mycosis fungoides
|
|
Erythroderma/red man syndrome
|
Mycosis fungoides
|
|
Hyperconvoluted and hyperchromatic nuclear membranes
|
Mycosis fungoides (Sezary cells)
|
|
Sezary cells, epidermotropism, Pautrier's microabscesses
|
Mycosis fungoides
|
|
Fried egg appearance on EM
|
Herpesvirus
|
|
Reye's syndrome
|
Varicella zoster virus (VZV)
|
|
Kaposi's sarcoma
|
HHV-8
|
|
Gingivostomatitis
|
HSV-1
|
|
Neonatal herpes
|
HSV-2
|
|
Herpes labialis
|
HSV-1
|
|
Herpes genitalis
|
HSV-2
|
|
Roseola infantum
|
HHV-6
|
|
HPV protein that degrades p53
|
E6
|
|
HPV protein that inactivates RB
|
E7
|
|
HPV protein that regulates E6 and E7 and is disrupted during linearization/integration into host genome
|
E2
|
|
HPV protein that decreases EGF receptor turnover
|
E5
|
|
Cause of warts on hands and feet
|
HPV types 1 and 2
|
|
Related to cervical cancer
|
HPV types 16 and 18
|
|
Related to benign genital disease (e.g., condyloma acuminatum)
|
HPV types 6 and 11
|
|
Koilocytosis is pathognomonic
|
HPV infection
|
|
Inflammatory tinea pedis
|
Trichophyton mentagrophytes
|
|
Reiter's syndrome
|
Chlamydia trachomatis
|
|
Strong causal association with PID, postabortive fever, postpartum fever
|
Mycoplasma hominis
|
|
Main causes of PID
|
Chlamydia trachomatis, Neisseria gonorrhoeae
|
|
Pruritic or malodorous frothy vaginal discharge; colpitis maculae; vaginal wall inflammation
|
Trichomoniasis (Trichomonas vaginalis)
|
|
Single, painless chancre with indurated edge and clean base
|
Syphilis (Treponema pallidum)
|
|
Multiple chancres with marked tenderness; soft edges and clean base
|
Chancroid (Haemophilus ducreyi)
|
|
Jarisch-Herxheimer reaction
|
Syphilis
|
|
Homogenous, adherent vaginal discharge with bubbles
|
Bacterial vaginosis (Gardnerella vaginalis)
|
|
Positive amine whiff test
|
Bacterial vaginosis (Gardnerella vaginalis)
|
|
Beefy red protuberant lesion; kissing lesions
|
Donovanosis (Calymmatobacterium granulomatis)
|