Biochemistry Pentose Phosphate Pathway

Front 1

4 totally awesome things you need NADPH for

Back 1

synthesis of steroid hormones

fatty acid synthesis

reduction of glutathione

PHAGOCYTOSIS

Front 2

rock star enzymes of the PPP

Back 2

transaldolase

transketolase

Front 3

what is that coenzyme that is necessary for the PPP

Back 3

TPP

thiamine pyrophosphate (vit B1)

needed by transketolase

Front 4

in the PPP, pentose sugars and NADPH are formed in the ____________ stage

Back 4

oxidative

Front 5

the first enzyme of the PPP

Back 5

Glucose 6-phosphate dehydrogenase


G6PD

makes one NADPH

Front 6

the 2 glycolytic intermediates produced by the non-oxidative part of the PPP

Back 6

Glyceraldehyde 3-phosphate

Fructose 6-P

Front 7

Transketolase

5 + 5 gives you

Back 7

3 + 7

Front 8

Transaldolase

3 + 7 gives you

Back 8

6 + 4

Front 9

Transketolase the second time

4 + 5 gives you

Back 9

6 + 3

Front 10

test for nutritional thymine status

Back 10

Transketolase in RBCs

Front 11

whats the sugar that's needed for nucleotide synthesis

Back 11

ribose 5-phosphate

Front 12

do RBCs make use of the nonoxidative phase of the PPP

Back 12

yeah, they don't need the ribose 5-phosphates

Front 13

2 more things NADPH is good for

Back 13

the cytochrome 450 system

synthesis of NO

Front 14

what do WBCs use NADPH for

Back 14

making those wicked lytic superoxidases

NADPH oxidase, there

deficiency causes chronic granulomatous disease, characterized by chronic infections

Front 15

somebody eats fava beans

or takes oxidant drugs like Sulfa drugs

or just gets an infection


and their eyes turn yellow.

Back 15

oxidative stresses

G6PD deficiency

Low NADPH to counter it

Front 16

G6PD A-

Back 16

a less severe mutation of the enzyme, compared to the mediterranean type