Biochemistry Glycolysis And Pdh

Front 1

Glycolysis

how many ATP go in

Back 1

2

Front 2

Glycolysis

net gain

Back 2

2 NADH

2 ATP

Front 3

flouride inhibits which enzyme

Back 3

enolase

Front 4

the only reversible kinase in glycolysis

Back 4

phosphoglycerate kinase

Front 5

what poison inhibits glyceraldehyde-phosphate dehydrogenase

Back 5

pentavalent arsenic

Front 6

Malate aspartate shuttle

what receives the H+ from NADH

Back 6

OAA, converts it to malate

Front 7

Malate aspartate shuttle

in the inner mitochondrial membrane, what does OAA get converted to and what molecule donates the amino group

Back 7

aspartate

glutamate

Front 8

the 5 cofactors of PDH

Back 8

thiamine pyrophosphate (vit B1)

coenzyme A (CoASH)

lipoic acid

FAD

NAD+

Front 9

is PDH active or inactive when phosphorylated

Back 9

inactive

PDH is active when dephosphorylated

Front 10

what makes wet beri-beri wet

Back 10

edema

congestive heart failure due to starvation of energy

Front 11

Leighs disease

Back 11

severe accumulation of lactic acid due to build up of pyruvate as a result of congenitally defective PDH complex

Front 12

what does trivalent arsenic do

Back 12

gobs up the disulfide swing arm of lipoic acid in PDH

Front 13

3 things that allosterically stimulate PFK1

Back 13

Fructose 2,6-bisphosphate

elevated [AMP]

elevated [Pi]

Front 14

3 things that allosterically inhibit PFK1

Back 14

elevated [ATP]

elevated [H+]

elevated [citrate]

Front 15

inhibition of pyruvate kinase

Back 15

elevated [ATP]

Front 16

activation of pyruvate kinase

Back 16

Fructose 1,6-bisphosphate

Front 17

the enzyme that catalyzes the transfer of an amino group from glutamate to oxaloacetate in the malate/aspartate shuttle

Back 17

aminotransferase

Front 18

what keeps the malate/aspartate shuttle from running in reverse

Back 18

cotransport of Glutamate into the mitochondrial matrix with H+

Front 19

how does pyruvate get into the inner mitochondrial matrix

Back 19

H+ symporter

since 4 H+ are required to make an ATP this is about I/4 of the cost of an ATP

Front 20

trivalent arsenic and Hg+ gob up the PDH lipoamide swing arm. What's the stuff that treats this?

Back 20

British Anti-Lewisite

aka Dimercaprol

Front 21

beri-beri is a deficiency of

Back 21

thiamine