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19 Cards in this Set
- Front
- Back
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Cell injury
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Reversible
Irreversible - necrosis & apoptosis -coag necrosis -liquefactive (brain) -caseating (TB) Adaptation -atrophy/hypertrophy -hyperplasia/dystrophy |
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Cytokines
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ACP --> IL-1 (activates CD4 T-cells)
CD4--> IL2 (activates NK & B cell), --> INF gamma (activates macrophage) T-cell--> IL2,4,5 (growth & diff. lymphocytes) Monocyte --> IL-6,8 (chemotaxis & activates neutrophils) |
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Interferon
-alpha -beta -gamma |
-From leukocytes (antiviral, MHC1)
-from fibroblast (antiviral, MHC1) -from T-cell (activates macrophage, MHCII) |
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Hypersensitivity Rxns
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I: IGE --> MC & Baso --> Histamine
(Anaphylaxis & asthma) II: IgG &IgM Ab:cell surface (transfusion rxn, autoimmune dz) III: IgM & IgG Immune complexes (serum sickness) IV: Tcell (memory) (TB & delayed) |
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Amyloid types
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Beta pleated sheets, stain Congo Red (green birefringence)
AL: light chains (multiple myeloma) AA: amyloid ass. protein (chronic inflam, aging) Abeta (alzeheimers) |
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Tumor suppressor gene
-RB1 -BRCA-1 -p53 |
-retinoblastoma
-breast & ovarian CA -breast & colon & bronchial CA |
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Mutation IL-2 R causes:
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SCID
(severe combined immunodeficiency) |
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Wound repair
(primary v. secondary intention |
Primary - surgical, contraction
Secondary - wound edges not attached, granulation tissue, takes longer |
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Autoantibody
RA |
Anti-IgG (Rheumatoid factor)
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Autoantibody
SLE |
Anti-nuclear Ab (ANA)
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Autoantibody
Drug-induced lupus |
Anti-histone
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Autoantibody
CREST |
Anti-centromere
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Autoantibody
Myasthenia gravis |
Anti-Ach R
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Autoantibody
Graves' disease |
Anti-TSH R
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Autoantibody
Hashimoto's thyroiditis |
Anti-microsomal
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Autoantibody
Wegner's granulomatosis |
Anti-neutrophil cytoplasm (ANCA)
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Autoantibody
Primary biliary cirrhosis |
Anti-mitochondrial
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Autoantibody
Celiac |
Anti-gladin
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Autoantibody
Goodpasture's syndrome |
Anti-glomerular basement membrane
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