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16 Cards in this Set
- Front
- Back
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What G proteins are the different histamine receptors coupled to?
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H1 - Gq
H2 - Gs H3, H4 - Gi |
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How does histamine cause the red spot in the wheal and flare response?
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actives H1 receptors on endothial cells which release NO to induce vasodilation of arterioles and postcapillary venuoles
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How does histamine cause the wheal in the wheal and flare response?
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actives H1 receptors on endothial cells which causes increased permeability and localized edema
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How does histamine cause the flare in the wheal and flare response?
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axon reflex that causes peripheral vasodilation
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How does histamine cause nasal congestion in allergic rhinitis?
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actives H1 receptors on endothial cells which release NO to induce vasodilation of arterioles and postcapillary venules in the nasal mucosa and inceases vascular permeability to cause localized edema
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Which antihistamines will treat allergic rhinitis?
1st and/or 2nd generation drugs? |
1st and 2nd generation drugs
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Which antihistamines will treat angioedema?
1st and/or 2nd generation drugs? |
1st and 2nd generation drugs
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Which antihistamines will treat insomnia?
1st and/or 2nd generation drugs? |
1st generation drugs
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Which antihistamines will treat motion sickness?
1st and/or 2nd generation drugs? |
1st generation drugs
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Which antihistamines will treat urticaria?
1st and/or 2nd generation drugs? |
1st and 2nd generation drugs
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Which agent will cross the BBB?
diphenhydramine or fexofenadine |
diphenhydramine
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Which agent will cause dry mouth, blurred vision, dry eyes, urinary retention?
diphenhydramine or loratadine |
diphenhydramine
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Which drug causes more sedation?
meclizine or loratidine? |
meclizine
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What can you use to treat acute poisoning from diphenhydramine?
atropine or physostigmine |
physostigmine
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Which of the following can you also use to treat allergice rhinitis?
atropine phenylepherine cromolyn albuterol epinephrine fluticasone montelukast |
phenylepherine
cromolyn fluticasone montelukast |
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what does histamine do to smooth muscle?
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most vascular smooth muscle - vasodilation via release of NO from endothelial cells
bronchial smooth muscle - direct vasoconstriction |
