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16 Cards in this Set

  • Front
  • Back
What G proteins are the different histamine receptors coupled to?
H1 - Gq
H2 - Gs
H3, H4 - Gi
How does histamine cause the red spot in the wheal and flare response?
actives H1 receptors on endothial cells which release NO to induce vasodilation of arterioles and postcapillary venuoles
How does histamine cause the wheal in the wheal and flare response?
actives H1 receptors on endothial cells which causes increased permeability and localized edema
How does histamine cause the flare in the wheal and flare response?
axon reflex that causes peripheral vasodilation
How does histamine cause nasal congestion in allergic rhinitis?
actives H1 receptors on endothial cells which release NO to induce vasodilation of arterioles and postcapillary venules in the nasal mucosa and inceases vascular permeability to cause localized edema
Which antihistamines will treat allergic rhinitis?
1st and/or 2nd generation drugs?
1st and 2nd generation drugs
Which antihistamines will treat angioedema?
1st and/or 2nd generation drugs?
1st and 2nd generation drugs
Which antihistamines will treat insomnia?
1st and/or 2nd generation drugs?
1st generation drugs
Which antihistamines will treat motion sickness?
1st and/or 2nd generation drugs?
1st generation drugs
Which antihistamines will treat urticaria?
1st and/or 2nd generation drugs?
1st and 2nd generation drugs
Which agent will cross the BBB?
diphenhydramine or fexofenadine
diphenhydramine
Which agent will cause dry mouth, blurred vision, dry eyes, urinary retention?
diphenhydramine or loratadine
diphenhydramine
Which drug causes more sedation?
meclizine or loratidine?
meclizine
What can you use to treat acute poisoning from diphenhydramine?
atropine or physostigmine
physostigmine
Which of the following can you also use to treat allergice rhinitis?
atropine
phenylepherine
cromolyn
albuterol
epinephrine
fluticasone
montelukast
phenylepherine
cromolyn
fluticasone
montelukast
what does histamine do to smooth muscle?
most vascular smooth muscle - vasodilation via release of NO from endothelial cells
bronchial smooth muscle - direct vasoconstriction