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24 Cards in this Set

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MOA sulfasalazine in inflammatory bowel disease
inhibits 5-lipoxygenase (mainly) to decrease production of leukotrienes - anti-inflammatory effect
sulfasalazine contains which 2 compounds?
5-ASA and sulfapyridine
Why is sulfapyridine a component of sulfasalazine?
enables delivery of 5-ASA to colon
Sulfasalazine would treat crohn's disease involving which part of the intestine?
duodenum
jejunum
ileum
colon
colon
Olsalazine will induce remission, maintain remission or both in a patient with inflammatory bowel disease
both
Clinical use of sulfasalazine - mild and/or severe inflammatory bowel disease
mild
Side effects of sulfasalazine
GI problems and hypersensitivity reactions (Fever, Skin rash, Hemolytic anemia, Agranulocytosis, Pancreatitis, Pulmonary complications, Hepatitis)
prednisone - will it induce remission, maintain remission or both in a patient with inflammatory bowel disease
induce remission
Clinical use of prednisone - mild, moderate, and/or severe inflammatory bowel disease
moderate and severe (can use 5-ASAs for mild disease)
what is steroid dependent inflammatory bowel disease?
A patient is on a steroid for their IBD. When they start to be weaned from the steroid, thier symptoms return.
Will azathioprine induce remission, maintain remission or both in a patient with inflammatory bowel disease
both
Will methotrexate induce remission, maintain remission or both in a patient with inflammatory bowel disease
both
Will cyclosporine induce remission, maintain remission or both in a patient with inflammatory bowel disease
induce remission
Will azathioprine be used to maintain remission in mild and/or severe inflammatory bowel disease
severe
Will methotrexate be used to maintain remission in mild and/or severe inflammatory bowel disease
severe
Which drug(s) would you use to induce remission in a patient with inflammatory bowel disease who is unresponsive to steroids?
budesonide
sulfasalazine
6-mercaptopurine
methotrexate
infliximab
6-mercaptopurine
methotrexate
infliximab
How long does it take for azathioprine to induce remission in a patient with inflammatory bowel disease
months
How long does it take for infliximab to induce remission in a patient with inflammatory bowel disease
couple of weeks
MOA of infliximab in inflammatory bowel disease
blocks TNF-alpha's role in inflammation
Is infliximab used for inducing remission, maintianing remission or both in a patient with inflammatory bowel disease?
both
Is infliximab used in mild and/or severe inflammatory bowel disease
severe
Are all TNF antagonists effective in treating inflammatory bowel disease
No
Where does sulfasalazine work?
in gut lumen or systemically
gut lumen
what is the difference between prednisone and budesonide?
budesonide has high first pass metabolism by the liver