H1 Antihistamines Research Paper

Symptoms of allergy can be treated with H1 antihistamines. The purpose of treatment is to prevent histamine to stimulate the receptors, why they consist of the same core structure as histamine . These H1 antihistamines constitute the second most commonly used class of medications after antibiotics and there are many varieties used in different conditions . H1 antihistamines are classified into six groups: ethanolamines, ethylene diamines, alkylamines, piperazines, piperadines, and phenothiazines . Since this classification is of limited clinical relevance, H1 antihistamines are also being classified as first- and second generation. First- and second generation antihistamines are also referred to as sedating and non-sedating antihistamines. First generation H1 antihistamines are non-selective in their binding to the H1 receptor . Many of them …show more content…
They are being used by many people of all ages. Many seek medical care to get into the right treatment but many others treat themselves with over-the-counter medication after advice from health care professionals at the pharmacy. Diagnosis depends on the presented symptoms. According to Institut for Rationel Farmakoterapi, all second generation antihistamines must be regarded as equal compared to their maximal efficacy . They differ in duration of action and notable side effects but it is very individual how to perceive the effects. Due to the individual preferences, it is not possible to find any guideline showing a recommendation list. The treatment is individually based. This thesis focus on the most sold first generation H1 antihistamine, PRO, and the two most sold second generation H1 antihistamines, CET and FEX . In the following sections, the focus is on these three antihistamines investigated for potential endocrine disrupting effect. Table 1 gives an overview of some of their relevant physiochemical and pharmacodynamics