Xxx - Uw Bchm

Front 1

Back 1

Methionine

Front 2

Back 2

Front 3

Back 3

5' - CAA - 3'

Front 4

The conversion of Homocysteine to Methionine requires what cofactor?

Back 4

Methyl-cobalamin (B12)

MTHF (Folic acid)

Front 5

B12 Deficiency

- besides cobalamin, what other cofactor can not be regenerated?

- thus what metabolism is impaired?

Back 5

- THF

- Folate

Front 6

In B12 & Folate deficiency, a defect in _______ results in megaloblastic erythropoeisis.

Back 6

- DNA synthesis

Front 7

Elevated Homocysteine is a risk factor for what 2 clinical conditions?

Back 7

- Arterial Thrombosis

- Venous Thrombosis

Front 8

Homocysteine is elevated in what vitamin deficiency?

Back 8

B12

Folic acid

Front 9

Methylmalonyl-CoA is elevated in what vitamin deficiency?

Back 9

B12 only

Front 10

Type III Hypercholesterolemia

- aka?
- Symptoms

Back 10

- Familial DysBetaLipoproteinemia

- Xanthomas
- Premature CVD
- Premature PVD

Front 11

Type III Hypercholesterolemia

- primary defect of what?
- these are found where?

Back 11

- ApoE3
- ApoE4

- Chylomicrons
- VLDL

Front 12

Type III Hypercholesterolemia

- primary defect of what?
- primary defect results in the Liver's inability to do what?

Back 12

- ApoE3 & ApoE4

- remove Extra remnants of chylomicrons and VLDL from circulation

Front 13

Type III Hypercholesterolemia

- accumulation of what lipoproteins?
- resulting accumulation of what else?

Back 13

- Chylomicrons
- VLDL

- Cholesterol
- TG

Front 14

CHYLOMICRONS

- synthesized on the RER & Golgi of what cells?

Back 14

- Intestinal enterocytes

Front 15

CHYLOMICRONS

- are released from enterocytes with what apolipoprotein?

- subsequently receive what apolipoproteins?

- receive from where?

Back 15

ApoB-48 (only)

ApoC-II
ApoE

HDL

Front 16

ApoB-100

- found by ITSELF in what lipoprotein?
- required for what?
(by what tissues?)

Back 16

- LDL

- Receptor-mediated uptake of LDL
(by extrahepatic tissues)

Front 17

Lipoprotein Lipase (LPL)

- is activated by what apolipoprotein?
- this apolipoprotein is carried by what lipoproteins?

Back 17

ApoC-II

Chylomicrons
VLDL

Front 18

ApoC-II Deficiency

- seen in what Dz?

Back 18

- Hyperchylomicronemia (Type I)

Front 19

Esterification of Free Cholesterol

- occurs in what lipoproteins?
- by what enzyme?
- requires what apolipoprotein?

Back 19

- HDL

- LCAT

- ApoA-1

Front 20

ApoA-1 & LCAT deficiencies

- increases what levels?
- decreases what levels?

Back 20

- Free Cholesterol

- HDL

Front 21

Increased plasma free cholesterol with decreased HDL implies a deficiency of what?

Back 21

- ApoA-1

- LCAT

Front 22

APOLIPOPROTEIN FUNCTIONS ***

- ApoA-1

Back 22

- LCAT activation

(for free cholesterol esterification in HDL)

Front 23

APOLIPOPROTEIN FUNCTIONS ***

- ApoB-48

(involving what cells?)

Back 23

(B48 drops chylomicron Bombs)

- Chylomicron secretion
(from intestinal enterocytes)

Front 24

APOLIPOPROTEIN FUNCTIONS ***

- ApoB-100

(by what cells?)

Back 24

- LDL uptake

(by extrahepatic cells)

Front 25

APOLIPOPROTEIN FUNCTIONS ***

- ApoC-II

Back 25

LPL activation

Front 26

APOLIPOPROTEIN FUNCTIONS ***

- ApoE3 & ApoE4

Back 26

- Chylomicron & VLDL remnant uptake

(by Liver cells)

Front 27

APOLIPOPROTEIN FUNCTIONS ***

- activates LCAT?

- activates LPL?

Back 27

- ApoA-1

- ApoC-2

Front 28

Apolipoprotein Requirements for Reuptake of:

- Chylomicrons? (by what cells?)
- VLDL? (by what cells?)
- LDL? (by what cells?)

Back 28

- Apo E (Liver cells)
- Apo E (Liver cells)

- Apo B100 (Extrahepatic cells)

Front 29

Older, mentally slow female of northern European descent who is "LEMON-COLORED", with a smooth, shiny tongue.

- classic presentation of what?
- secondary to what etiology?
- what does "lemon-colored" mean?
- smooth, shiny tongue indicative of?
- patient would also demonstrate what type of gait?

Back 29

- Pernicious anemia
(classic presentation)

- Anemic & Icteric

- Atophic Glossitis

- Shuffling, broad-based gait

Front 30

What antibiotic inhibits the Peptidyltransferase enzyme?

Back 30

ChloramPhenicol

Front 31

What antibiotic inhibits the Translocation step?

Back 31

Macrolides

(i.e. - Clindamycin & Erythromycin)

Front 32

What antibiotic interferes with the binding of aminoacyl-tRNA to the A site?

Back 32

Tetracycline

Front 33

ANGIOKERATOMAS

- describe
- seen in what Dz?
- angiokeratomas seen where classically in this Dz?

Back 33

- Punctate, Dark, Red, & NON-Blanching maculopapules

- Fabry's Dz

- btw Umbilicus & Knees

Front 34

FABRY'S DISEASE

- enzyme def.?
- accumulation of?
- without enzyme replacement, what is the greatest risk leading to death?

Back 34

- Galactosidase A

- Ceramide Trihexosides

- progressive Renal Failure

Front 35

What accounts for Elastin's resilient properties?

Back 35

- extensive Desmosine Crosslinking

Front 36

How is Elastin different from Collagen

Back 36

- very few proline & lysine Hydroxylations

- lacks triple helices

Front 37

Desmosine Crosslinking

- extensive in what collagen-like tissue
- catalyzed by what enzyme?

Back 37

- Elastin

- Lysyl-Hydroxylase
(extracellular)

Front 38

PCR

- what must be known about the target DNA?
- requires what kind of triphosphates?

Back 38

- Flanking sequences
(target sequence itself does not need to be known)

- Deoxy-nucleotide triphosphates