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19 Cards in this Set
- Front
- Back
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Is there antiviral treatment for GI viruses?
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No, only supportive care
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In which groups do GI viruses cause serious disease?
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In those not able to rehydrate. Ex: elderly, very young, disabled
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Are GI viruses enveloped or nonenveloped?
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Nonenveloped - very sturdy outside the body
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What is the standard GI virus pathogenesis?
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- Replicates quickly in epithelia of intestinal villi
- shortening/blunting of villi - elongation of crypts - mononuclear infiltration into lamina propria - Leads to isotonic dehydration |
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What has been considered the single most important cause of severe dehydrating diarrhea?
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Rotavirus
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What are the cellular characteristics of Rotavirus?
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- Reovirus
- dsRNA - Non enveloped - Segmented genome - RESEMBLES WHEELS - VP6 capsid protein determines group/subgroup |
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What 3 serogroups of Rotavirus infect humans?
Of those, which is the most important? |
A, B, C
A is the most important |
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How are all GI viruses diagnosed?
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- Lab diagnosis difficult
- Antigen detection for Rotavirus and Adenovirus 40/41 |
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What are the symptoms of Rotavirus?
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- Acute gastroenteritis (standard symptoms)
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How is Rotavirus treated?
Vaccine? |
- No antiviral therapy
- Pentavalent live vaccine (RotaTeq) for infants and live oral vaccine (Rotarix) |
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How is Rotavirus transmitted?
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- Fecal/oral
- Person may excrete 1 trillion particles / ml |
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Which two viruses are in the Calicivirus (cup) family?
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Norovirus (SRSV) and Sapovirus (TCV)
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What is the leading cause of viral gastroenteritis in adults/older children?
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Norovirus (SRSV)
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How is Norovirus transmitted?
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- Fecal/oral
- cruise ships, restaurants - contaminated food/water |
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What are the cellular characteristics of Adenovirus?
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- Non-enveloped
- dsDNA - 51 serotypes in subgroups A-F infect humans |
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How does the incubation period of enteric Adenovirus compare to other GI viruses?
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It is longer (8-10 days)
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Which enteric adenovirus types cause acute gastroenteritis?
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Types 40-41
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Which GI Virus has prolonged viral shedding (1-3 weeks)?
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NoroVirus (SRSV)
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What are the cellular characteristics of Astrovirus?
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- Small, round
- Star like - nonenveloped - ssRNA |
