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48 Cards in this Set

  • Front
  • Back
what is atherosclerosis?
diffuse disease process in arteries; atheromas containing cholesterol and lipid form w/in the intima and inner media, often accompanied by ulcerations and smooth muscle hyperplasia
what is the common theory of how atherosclerosis is initiated?
endothelial injury --> platelet adhere --> growth factors released --> smooth muscle hyperplasia/plaque deposition
what are the risk factors for atherosclerosis?
HTN, SMOKINT, diabetes mellitus, family hx, hypercholesterolemia, high LDL, obesity, sedentery lifestyle
what are the common sites of plaque formation in arteries?
branch points (carotid bifurcation), tethered sites (superficial femoral artery in hunter's canal in the left)
what must be present for a successful arterial bypass operation?
1. inflow (e.g., patent aorta). 2. outflow (e.g., open distal popliteal artery). 3. run off (e.g., patent trifurcation vessels down to the foot)
what is the major principle of safe vascular surgery?
get PROXIMAL and DISTAL control of the vessel to be worden on
what does it mean to POTTS a vessel?
place a vessel loop 2x around a vessel so that if you put tension on the vessel loop it will occlude the vessel
what is the suture needle orientation through graft v. diseased artery in a graft to artery anastomosis?
needle in-to-out of the lumen in diseased artery to help tack down the plaque and the needle out-to-in on the graft
what are the 3 layers of an artery?
intima, media, adventitia
which arteries supply the blood vessel itself?
vaso vasorum
what is a true aneurysm? what is a false aneurysm (AKA pseudoaneurysm)
true: dilation (>2x nl diameter) of all 3 layers of a vessel. false: dilation of artery not involving all 3 layers (e.g., hematoma w/fibrous covering), often connects w/vessel lumen and blood swirls inside the false aneurysm
what is endovascular repair?
placement of a catheter in artery and then deployment of a graft intraluminally
what is the orientation of the lower exterior arteries below the knee on A-gram?
LAMP: lateral - anterior tibial, medial - posterior tibial
what is peripheral vascular disease?
occlusive atherosclerotic disease in the lower extremities
what is the most common site of arterial atherosclerotic occlusion in the lower extremities?
occlusion of the SFA in hunter's canal
what are the symptoms of PVD?
intermittent claudication, rest pain, erectile dysfunction, sensorimotor impairment, tissue loss
what is intermittent claudication?
pain, cramping, or both of the lower extremity, usually the calf muscle, after walking a specific distance; then the pain/cramping resolves after stopping for a specific amt of time while standing; this pattern is reproducible
what is rest pain?
pain in the foot, usually over the distal metatarsals; this pain arises at rest (classically at night, waking up the patient)
what classically resolves rest pain?
hanging the foot over the side of the bed or standing; gravity affords extra flow to ischemic areas
how can vascular causes of claudication be differentiated from nonvascular causes, such as neurogenic claudication or arthritis?
history (in vast majority of patients) and noninvasive tests; remember, vascular claudication appears after a specific distance and resolves after a specific time of rest while standing (not so w/most other forms of claudication)
what is the DDx of lower extremity claudication?
neurogenic (e.g., nerve entrapment/discs), arthritis, coarcation of the aorta, popliteal artery syndrome, chronic compartment syndrome, neuromas, anemia, diabetic neuropathy pain
what are the signs of PVD?
absent pulses, bruits, muscular atrophy, decreased hair growth, thick toenails, tissue necrosis/ulcers/infection
what is the site of a PVD ulcer v. a venous stasis ulcer?
PVD arterial insufficiency ulcer - usually on toes/foot. venous stasis ulcer - medial malleolus (ankle).
what is the ABI?
ankle to brachial index --> ratio of systolic blood pressure at the ankle to systolic blood pressure at the arm (brahcial artery) A:B; ankle pressure taken w/doppler, ABI is noninvasive
what ABIs are associated w/normals, claudicators, and rest pain?
normal ABI >=1.0, claudicator ABI <0.6, rest pain ABI <0.4
who gets false ABI readings?
patients w/calcified arteries, especially those w/diabetes
what are PVRs?
pulse volume recordings --> pulse wave forms are recorded from lower extremities representing volume of blood per heart beat at sequential sites down leg; large wave form means good collateral blood flow (noninvasive using pressure cuffs)
prior to surgery for chronic PVD, what diagnostic test will every patient receive?
a-gram (arteriogram: dye in vessel and x-rays) maps disease and allows for best treatment option (i.e., angioplasty v. surgical bypass v. endarterectomy); gold-standard for diagnosing PVD
what is the bedside management of a patient w/PVD?
1. sheep skin (easy on the heels). 2. foot cradles (keeps sheets/blankets off feet). 3. skin lotion to avoid further cracks in the skin that can go on to form a fissure and then an ulcer
what are the indications for surgical treatment in PVD?
STIR: severe claudication refractory to conservative tx that affects quality of life/livelihood, tissue necrosis, infection, rest pain
how does aspirin work for PVD tx?
inhibits platelets (inhibits cyclooxygenase and platelet aggregation)
how does trental (pentoxifylline) work?
results in increased RBC deformity and flexibility
what is the treatment of claudication?
for the vast majority, conservative treatment, including exercise, smoking cessation, treatment of HTN, diet, aspirin, w/ or w/o Trental (pentoxifylline). (remember PACE: pentoxifylline, aspirin, cessation of smoking, exercise)
what is the risk of limb loss w/claudication? w/rest pain?
w/claudication: 5% limb loss at 5 yrs, 10% at 10 yrs. w/rest pain: >50% of patients will have amputation of limb at some point.
in the patient w/PVD, what is the main postop concern?
cardiac status, b/c most patients w/PVD ahve coronary artery disease, ~20% have an AAA. MI is the most common cause of postop death after a PVD operation
what is leriche's syndrome?
buttock claudication, impotence (erectile dysfunction, and leg muscle atrophy from occlusive disease of the iliacs/distal aorta (CIA)
what are the tx options for severe PVD?
1. surgical graft bypass 2. angioplasty - balloon dilation 3. endarterectomy - remove diseased intima and media 4. surgical patch angioplasty (place patch over stenosis)
what is a FEM-POP bypass?
bypass SFA occlusion w/a graft from the femoral artery to the popliteal artery
what is a FEM-DISTAL bypass?
bypass from the femoral artery to a distal artery (peroneal artery, anterior tibial artery, or posterior tibial artery)
what graft material has the longest patency rate?
autologous vein graft
what is an in situ vein graft?
saphenous vein is more or less left in place, all branches are ligated, and the vein valves are broken w/a small hook or cut out; a vein can also be used if reversed so that the valves do not cause a problem
what type of graft is used for above the knee FEM-POP bypass?
either vein or gortex graft; vein still has better patency
what type of graft is used for below the knee FEM-POP or FEM-DISTAL bypass?
must use vein graft; prosthetic grafts have a prohibitive thrombosis rate?
what is dry gangrene? wet gangrene?
dry gangrene: dry necrosis of tissue w/o signs of infection (mummified tissue). wet gangrene: moist necrotic tissue w/signs of infection?
what is blue toe syndrome?
intermittent painful blue toes (or gingers) due to microemboli from a proximal arterial plaque
what are the indications for lower extremity amputations?
irreversible tissue ischemia (no hope for revascularization bypass) and necrotic tissue, severe infection, severe pain w/no bypassable vessels, or if patient is not interested in a bypass procedure
what are the level of lower extremity amputations?
above the knee (AKA), below the knee (BKA), symes amputation (ankle), transmetatarsal amputation, toe amputation
what is a ray amputation?
removal of toe and head of metatarsal