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21 Cards in this Set
- Front
- Back
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What type of Histamine receptors to histamine blockers block?
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Type 2
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Name three side effects of cimetidine that the other H2 blockers don't have:
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cyt p450 inhibitor
anti-androgenic (dec. libido, gynecomastia) crosses BBB - confusion, dizziness, etc. |
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What side effect do both cimetidine and ranitidine have?
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decrease renal excretion of creatinine
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What is the mechanism of action of bismuth?
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Binds to ulcer base, providing physical protection and allowing HCO3- to re-establish pH gradient in the mucous layer
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Name three uses for misoprostol
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1) prevention of NSAID-induced peptic ulcers
2) maintenance of a PDA 3) to induce labor |
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Two toxicities of misoprostol?
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diarrhea, abortion in pregnant women
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What is the MOA of pirenzepine?
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muscarinic antagonist
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What is the MOA of propantheline?
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muscarinic antagonist
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For what GI indicated might you use a muscarinic antagonist?
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peptic ulcer (rarely used)
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What is octreotide (MOA)?
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somatostatin analog
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What electrolyte abnormality can all antacids cause?
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hypokalemia
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What is the MOA of sulfasalazine?
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combo of anti- bacterial (sulfapyridine) and anti-inflammatory (5-ASA)
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What is sulfasalazine/5-ASA used to treat?
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Mostly UC, I think.
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Why is sulfasalazine a better drug for UC than for Crohn's?
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bc it needs to activated by colonic bacteria; UC always has colon involvement
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What are the side effects of sulfasalazine?
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malaise, nausea, sulfonamide toxicity, reversible oligospermia
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Odansetron has what MOA?
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5HT3 antagonist
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Odansetron has what toxicity?
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headache, constipation
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What is the MOA of metoclopromide?
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D2 receptor antagonist and serotonin antagonist
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What is the clinical use of metoclopromide?
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to fix diabetic & post-surgical gastroparesis
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What is the toxicity (side effects) of metoclopromide?
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Parkinsonian effects
restless ness, drowsiness, depression, nausea, diarrhea |
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What two drugs does metoclopromide interact with?
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digoxin & diabetic agents
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