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15 Cards in this Set

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  • Back
Drug of choice for cytomegalic retinitis in immunocompromised patients?
Why is CMV resistant to Acyclovir?
CMV is deficient in thymidine kinase, therefore forms triphosphate by another route
Describe the action of thymidine kinase (viral) on acyclovir?
It phosphorylates acyclovir to monophosphorylated) thus allowing further phosphorylations by host enzymes
How does acyclovir inactivate viral DNA polymerase?
by being incorporated into the growing viral DNA chain it terminates elongation and binds irreversibly to viral DNA polymerase thus leading to inactivation.
The drug of choice for herpes infected cells that divide is?
Drug similar to ganciclovir but used to treat herpes zoster infections?
famciclovir-a prodrug that must be metabolized to penciclovir.
This drug is used to treat ganciclovir resistant CMV in patient with HIV?
Foscarnet (not a purine or pyrimidine analog. It inhibits viral DNA and RNA polymerases.
This drug is a pyrophosphate analog that binds to the pyrophosphate binding site of viral RNA and DNA polymerase leading to inactivation
Inhibits influenza neuraminidase
Zanamivir and Oseltamivir
Inhibits synthesis of guanine nucleotides by competitively inhibiting IMP dehydrogenase
Drug of choice for RSV and chronic hepatitis?
Blocks viral penetration/uncoating
This antiviral causes release of dopamine thus having an addition benefit?
This antiviral causes ataxia, dizziness, and slurred speech? What is an alternative?
Amantadine thus use Rimantidine which has less CNS complications
This antiviral inhibits viral DNA polymerase when phosphorylated by viral thymidine kinase