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10 Cards in this Set
- Front
- Back
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Synaptic transmission step 1 |
Action potential arrives at presynaptic terminal (axon terminal) and causes voltage gated Ca2+ ion channels to open |
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Synaptic transmission step 2 |
Ca2+ ions diffuse into cell and cause synaptic vesicles to fuse with presynaptic membrane |
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Synaptic transmission step 3 |
Neurotransmitter is released into synaptic cleft |
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Synaptic transmission step 4 |
Neurotransmitter diffuses across synaptic cleft |
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Synaptic transmission step 5 |
Neurotransmitter binds to receptor sites on ligand-gated Na+ channels in postsynaptic neuron |
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Synaptic transmission step 6 |
The shape of the neurotransmitter and receptor are complimentary (fit together, like puzzle piece) |
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Synaptic transmission step 7 |
Na+ ions diffuse into postsynaptic neuron which depolarises the membrane |
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Synaptic transmission step 8 |
If the threshold is reached, action potential is produced in the postsynaptic neuron |
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Synaptic transmission step 9 |
Neurotransmitter diffuses away from receptor and removed from synaptic cleft |
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Effects of drugs on the synapse, drugs at the synapse can |
-Block or stimulate the ligand-gated receptors in the post synaptic neuron
-Block the protein channels that take the neurotransmitter back up into the presynaptic neuron
-Prevent the enzyme that breaks down the neurotransmitter from working by inhibiting it |
