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217 Cards in this Set

  • Front
  • Back

How do people get Giardia lamblia?

Unfiltered or unpurified drinking water contaminated byhuman/animal feces with Giardia cysts

How is Giardia lamblia transmitted?

Fecal/oral transmission via cysts

What is Giardia lamblia associated with?

Campers/hikers

Symptoms of Giardia lamblia (3)

1. Foul smelling diarrhea
2. Steattorhea
3. Vitamin DEAK malabsorption

Pathogenesis of Giardia lamblia

Trophozoite attach but does not invade intestinal wall,which means doesn’t cause bloody diarrhea

How do you diagnose Giardia lamblia? (3)

1. Trophozoites in stool is diagnostic

2. Stool O&P is diagnostic test

3. ELISA stool antigen test is also diagnostic

How do you treat Giardia lamblia?

Metronidazole

How is Entamoeba histolytica transmitted?

Cyst form is infectious, ingested in contaminated waters

What is associated with Entamoeba histolytica?

Associated with men who have sex with men via anal oraltransmission

Pathogenesis of Entamoeba histolytica?

In GI tract, differentiates into trophozoites which invadescolon and spreads via portal circulation to liver

Where is the most common site of Entamoeba histolytica abscesses

Right lobe of liver

Symptoms of Entamoeba histolytica (3)

1. RUQ pain
2. Hepatomegaly
3. Bloody diarrhea

Describe the Entamoeba histolytica liver abscess

consistencyof anchovy paste

How does the colon look in Entamoeba histolytica infections?

Intestinal amebiasis: flask shaped ulcerations in colon

Is Entamoeba histolytica invasive?

Yes

How do you diagnose Entamoeba histolytica? (3)

1.

Diagnosis with Stool O&P – trophozoites with endocytosedRBCs under microscope


2.

Elisa stool antigen test


3.

Intestinal biopsy may show flask shaped lesions

How do you treat Entamoeba histolytica? (4)

1. Metronidazole treatment
2. Paramycin – luminal agent to eliminate cysts
3. Iodoquinol – luminal agent to eliminate cysts
4. Treat medically NOT surgically

Do you treat Entamoeba histolytica medically, surgically or both?

Medically only

How do you treat Entamoeba histolytica in the lumen to eliminate cysts?

1. Paramycin

2. Iodoquinol

How does Cryptosporidium in the immunocompromised compared to the immunocompetent?

1. Severe watery diarrhea in HIV patients
2. Mild watery diarrhea in immunocompetent

Describe the life cycle of Cryptosporidium

Complete life cycle in single host

What is the only acid fast parasite?

Cryptosporidium

How is Cryptosporidium transmitted?

Fecal-oral transmission

How does a person acquire Cryptosporidium?

Infectious cysts passed through spores ingested in infected water

What is unique about the cysts of Cryptosporidium?

Each cyst is composed of 4 motile sporozoites

Pathgenesis of Cryptosporidium

Sporozoites attached to intestinal wall, cause diarrhea andsmall intestine damage

What is the most common location in the body for Cryptosporidium?

Small intestine

How do you diagnose Cryptosporidium?

Diagnose with Stool O&P

How do you treat Cryptosporidium? (2)

1. Nitazoxanide treatment – antiprotoza that can be usedexclusively in immunocompromised

2. Spiramycin (outside the US)

How do you prevent Cryptosporidium infection?

Filtration can remove oocysts from infected water (resistantto chlorination)

Can you treat Cryptosporidium infected water with chlorine?

No-resistant, must filter

What is a buzz word for Toxoplasmosis gondii?

Cats

What patients are at risk for Toxoplasmosis gondii?

Pregnant and immunocompromised, especially HIV at risk

How is Toxoplasmosis gondii transmitted? (3)

1. Raw or undercooked meat containing cysts

2. water/vegetablescontaining oocytes shed in the feces of infected animals transmission

3. Pregnant women at risk of transplacental transmission(TORCHES)

What do you find on imaging with Toxoplasmosis gondii?

Ring enhancing lesions on CT or MRI in immunocompromised,usually multiple lesions

Major symptom of Toxoplasmosis

Encephalitis

What do you have to differentiate Toxoplasmosis from?

CNS lymphoma

How do you differentiate Toxoplasmosis from CNS lymphoma?

Brain biopsy to differentiate from CNS lymphoma (also CNSlymphoma usually only one lesion)

Congenital Toxoplasmosis Features (5)

1. Intracranial calcifications

2. Hydrocephalus

3. Seizures

4. Chorioretinitis

5. Deafness

How do you diagnose Toxoplasmosis?

Diagnosis made by serology or biopsy, but positive serologydoesn’t indicate active infection given a large portion of the population hastoxoplasmosis exposure but asymptomatic

Does positive serology indicate active Toxoplasmosis infection?

No because a large portion of the population has toxoplasmosis but asymptomatic

How do you treat Toxoplasmosis? (2)

1. sulfadiazine

2. pyrimethamine

When do you need to prophylactically treat for Toxoplasmosis? (2)

1. Prophylaxisfor CD4 count < 100 AND MUST HAVE

2. seropositive for IgG against Toxoplasmosis

What do you give for prophylaxis against Toxoplasmosis

TMP-SMX

Disease caused by Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense?

African sleeping sickness

Location of Trypanosoma brucei gambiense

West Africa

Location of Trypanosoma brucei rhodesiense

Southeast Africa

How is African sleeping sickness transmitted?

Tsete fly vector

Symptoms of African sleeping sickness (3)

1. Coma (penetrates CNS)

2. Cervical/Axillary lymphadenopathy
3. Recurrent fevers

Pathogenesis of African sleeping sickness

After biting moves from blood to lymph nodes(cervical/axillary lymphadenopathy)

How do you diagnose African sleeping sickness?

Trypomastigotes seen on blood smear

What is a major reason for Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense's ability to avoid the immune system?

Variable surface glycoprotein coats, undergoing constantantigenic variation

How would you describe how Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense?

Motile with single flagella

How do you treat African sleeping sickness? (2)

1. Melarsoprol treatment – CNS infection

2. Suramin treatment – Peripheral blood infection

What is Naegleria fowleri associated with? (5)

1. Freshwater

2. Water sports

3. Hot springs

4. Nasal irrigation symptoms
5. Contact lens symptoms

How would you describe the form of Naegleria fowleri?

Amoeba

What is the prognosis of Naegleria fowleri?

High mortality rate, rapidly fatal with poor prognosis

What disease does Naegleria fowleri cause?

Primary amoebic meningoencephalitis

How does Naegleria fowleri cause its symptoms?

Trophozoite enters CNS via cribiform plate

How do you diagnose Naegleria fowleri?

Lumbar puncture you see amoebas

How do you treat Naegleria fowler?

Amphoterocin B

Where do you find Trypanosoma cruzi regionally?

South America and Central America

What disease does Trypanosoma cruzi cause?

Chagas disease

How does a person get infected with Trypanosoma cruzi?

“Kissing Bug” bites around victim’s mouth and depositsinfected feces which can later be introduced by scratching area

How is Chagas disease transmitted?

Transmitted by Reduviid aka Kissing bug

Symptoms of Chagas disease (3)
1. Megacolon
2. Dilated cardiomyopathy
3. Mega-esophagus

How do you diagnose Chagas disease?

1. Diagnosed by blood smear in active infection – motiletrypanosomes

2. Trypanosomes may be seen within cardiac myocytes on heartbiopsy

How do you diagnose chronic Chagas disease?

diagnosedvia serology and clinical

How does Trypanosoma cruzi reach the heart?

Burrows into endocardium from blood stream

How do you treat Chagas disease?

Nifurtimox actuely

How do you treat chronic Chagas disease?

No treatment

How is Babesia transmitted?

Tick borne illness – Ixodes/Deer Tick – Northeast America(often coinfection with Borrelia)

What coinfection can occur with Babesia?

Borrelia

Symptoms of Babesia (5)

1. Blood-related symptoms: hemolytic anemia, hemoglobinuria,jaundice

2. Sweat

3. Irregularly cycling fever

How is Babesia diagnosed? (2)

1. Thick blood smear

2. Maltese cross appearance in RBC (tetrad of trophozoites)

Who is at higher risk of severe disease of Babesia?

Sickle cell disease/asplenia

How do you treat Babesia? (2)

1. Atovaquone

2. Azithromycin

Can healthy people recover from Babesia spontaneously?

Yes

How do you diagnose Plasmodium?

Blood stain and Giemsa stain to see parasites in RBCs

Describe the fever in Plasmodium malariae?

Quartan fever schedule – every 72 hours (4 days)

Describe the fever in Plasmodium vivax

Tertian fever cycles (48 hours, every third day)

Describe the fever in Plasmodium ovale

Tertian fever cycles (48 hours, every third day)

Plasmodium vivax produces _______ ________ in _______

Produce dormant hypnozoites in hepatocytes

Plasmodium ovale produces _______ ________ in _______

Produce dormant hypnozoites in hepatocytes

Symptoms of Plasmodium falciparum (3)

1.

Irregular fever patterns


2.

Cerebral malaria


3.

Parasitized RBC’s occlude vessels to lungs and kidneys

What does Plasmodium falciparum look like on peripheral blood smear?

Banana shaped

Chloroquine mechanism (2)

1. blocksPlasmodium heme polymerase

2. high resistance against this drug already

Primaquine


1. Uses

2. Mechanism/Side effect
1. Treats P. ovale or P. vivax
2. Destroyshypnozoites in liver (must check for G6PD deficiency or else risk anemia)

Mefloquine (2)

1. goodagainst resistance species of all Plasmodium species

2. also good for prophylaxis for travelers tochloroquine resistant countries

Atovaquone and Proguanil combined

goodfor prophylaxis and treatment for travelers in chloroquine resistant areas for P. vivax and P. ovale

How do you treat P. falciparum? (2+)

artemisins




OR




Atovaquone/Proguanilcombo

How do you severe malaria infections?

IV artesunate

How do you treat super resistant malaria? (Any side effects)

1. IV Quinidine

2. Cinchonism-whichincludes headaches, tinnitus

Pathogenesis of malaria

Transmitted via anopheles mosquitoes carrying sporozoites insaliva => mature to trophozoites in liver => Schizont divides intomerozoites which burst from hepatocyte and infect RBCs => inside RBC becomestrophozoite => Schizont => Ruptured RBC releasing merozoites => infectother RBC

What does malaria look like in RBC?

Ring form of immature schizont shape in RBC

How does malaria spread from one person to another?

Merozoites can also form gametocytes in RBC to spreadinfection via mosquito bite to other

Host of Leishmaniasisbraziliensis

Vertebrates

What disease is caused by Leishmaniasisbraziliensis?

Cutaneous leishmaniasis

Cutaneous leishmaniasis type of disease

Flesh eating

Pathogenesis of Cutaneous leishmaniasis

sandflyvector carrying promastagote (infective form) => becomes amastogote-intracellular form in macrophages

Is Leishmaniasis braziliensis intracellular form?

Yes

What is the vector for Leishmaniasis braziliensis?

Sandfly

How do you treat cutaneousleishmaniasis?

Stibugluconate

What disease is caused by Leishmaniasisdonovani?

Visceral leishmaniasis

Where do you find Leishmaniasis donovani regionally?

Mediterranean


Middle East


Africa

Features of Leishmaniasis donovani

1. Black fever, or kala-azar

2. Pancytopenia when bone marrow affectedHepatosplenomegaly

How do you treat visceral leishmaniasis?

Amphotericin B

What does Trichomonas vaginalis cause? (2)

1. Vaginitis

2. Cervicitis

Describe the cervix in Trichomonas vaginalis

Strawberry cervix

Symptoms of Trichomonas vaginalis (2)

1. Burning/itching
2. malodorous Yellow green vaginal discharge

How do you diagnose Trichomonas vaginalis?

Wet-Mount showing motile trophozoites

What pH is required for Trichomonas vaginalis?

Vaginal fluid pH > 4.5

How is Trichomonas vaginalis transmitted?

STD

How do you treat Trichomonas vaginalis?

Metronidazole

What type of parasite is Enterobius vermicularis?

1. Intestinal nematode

2. Pinworm

Pathogenesis/Transmission of Enterobius vermicularis? (3)

1. Female worms at night lay eggs at the anus
2. Fecal/oral route transmission
3. Repeat infection- itchy, scratch butt, touch mouth
How do you test for Enterobius vermicularis?


Scotch tape test shows eggs under microscope (tape to anusin the morning)

How do you treat Enterobius vermicularis?

1. Pyrantelpamoate or

2. Albendazole

What group of people often gets Enterobius vermicularis?

Children

What type of parasite is Ancyclostomaduodenale?

1. Intestinal nematode

2. Hookworm

Where do you find Ancyclostomaduodenale regionally?

Rural southern US

Pathogenesis of Ancyclostomaduodenale

Hookwormlarvae penetrate skin of soles of feet => blood stream => lungs =>coughed up and swallowed => Small intestines

Features of Ancyclostoma duodenale (3)

1. Iron deficiency anemia

2. Eggs in stool

3. High eosinophil count

How do you treat Ancyclostoma duodenale? (2)

1. Pyrantelpamoate or

2. Albendazole

What is Necator americanus similar to?

Ancyclostoma duodenale

What is Ancyclostoma duodenale most similar to?

Nectar americanus

What type of parasite is Ascaroslumbricoides?

1. Intestinal nematode
2. Giant round worm

How is Ascaros lumbricoides transmitted?

Eatingeggs in contaminated food or water

Pathogenesis of Ascaros lumbricoides

GItract => blood stream => lungs => coughed up => swallowed => GItract (small intestine)

Ascaros lumbricoides features (4)

1. Respiratory symptoms
2. intestinal obstruction at Ileocecal valve
3. Eggs in stool
4. Eosinophilia

How do you treat Ascaros lumbricoides? (2)



1. Treatwith Albendazole (microtubule dysfunction => immotile)

2. don’t give topregnant women instead give Pyrantel pamoate

How do you treat Ascaros lumbricoides in pregnant women?

Pyrantel pamoate

How do you contract Strongyloides stercoralis?

Larvae penetrate skin of soles of feet

Type of parasite Strongyloides stercoralis

1. Intestinal nematode
2. Hookworm

Pathogenesis of Strongyloides stercoralis (2)

1. Hookwormlarvae penetrate skin of soles of feet => blood stream => lungs =>coughed up and swallowed => Small intestines

2. autoinfectionand repeat cycle by repenetrating intestinal wall

What is the problem with Strongyloides stercoralis in immunocompromised?

immunocompromisedcan lead to hyperinfection and dissemination

What do you find in the stool in Strongyloides stercoralis and why?

Eggs layed into intestinal wall so only find larvae instool NOT eggs

Do you see eosinophilia with Strongyloides stercoralis infection?

Yes

How do you treat Strongyloides stercoralis?

1. Albendazole or

2. Ivermerctin

How is Trichinella spiralis transmitted?

Uncooked pork or bear containing cysts

Features of Trichinella spiralis (5)

1. periorbital edema
2. vomiting
3. fever
4. myalgias
5. eosinophilia

Pathogenesis of Trichinella spiralis

Larvaeenter blood stream => striated muscle => larvae form cysts within striatedmuscle => muscle inflammation

How do you treat Trichinella spiralis?

Albendazole

How is Dracunulus medinensis transmitted?

transmittedvia drinking contaminated water with copepods (tiny crustaceans infreshwater/sea-intermediate hosts) containing larvae

Pathogenesis of Dracunulus medinensis

Drink copepods => copepods die => larvae released=> maturation in abdominal cavity => migrate to skin => skin ulcers

Dracunulus medinensis Features

1. Adultfemales emerge from painful ulcer in skin

2. Slowly over days use small stick to ease worm out of skin,sometimes metronidazole can speed up process

3. Eosinophilia

How is Onchocerca volvulus transmitted?

Black flies found around rivers of Africa, Central America, South America

Pathogenesis of Onchocerca volvulus

blackfly deposits larvae via bite into skin => mature into adults => producemicrofilariae

Features of Onchocerca volvulus (3)

1.

Hyper/hypo-pigmented spots occur with onchodermatitis(hypopigmented normally on shins of older patients)


2.

Can sometimes float into eye and Microfilariae causeblindness => river blindness


3.

Eosinophilia

How do you diagnose Onchocerca volvulus?

Diagnosed by microfilariae seen in skin biopsy undermicroscope

How do you treat Onchocerca volvulus?

Ivermectin

Features of Wuchereria bancrofti (3)

1. elephantiasis – long standing lower extremity lymphedema
2. cough from microfilariae in lungs (hypersensitivityreaction)

3. Eosinophilia

How is Wuchereria bancrofti transmitted?

Mosquitos deposit larvae on skin

How do you diagnose Wuchereria bancrofti?

Thick blood smear

How do you treat Wuchereria bancrofti?

Diethylcarbamazine

How is Toxocara canis transmitted?

Transmitted via food contaminated with dog/cat feces

Features of Toxcara canis (3)

1. circulate in body larva form indefinitely

2. ocular larva migrans => lead to blindness

3. eosinophilia

How do you treat Toxocara canis?

Albendazole

Pathogenesis of Loa loa

Worm migrates through subcutaneous tissue causing transientangioedema called Calibar swellings

Features of Loa loa (3)

1. local subcutaneous swellings
2. Adult worms can migrate across conjunctiva – African eyeworm another name

3. Eosinophilia

How is Loa loa diagnosed?

Blood smear can see Microfilariare

How is Loa loa treated? (2)

1. Diethycarbamazine

2. Albendazole

How is Taenia transmitted and what is the general symptom?

undercookedmeat => GI problems

What is the intermediate host for Taenia saginata?

Cattle

What is the intermediate host for Taenia solium?

Pigs

What is the difference between T. saginata and T. solium in appearance?

Hooks on proglottid heads of T. solium seen on O&P

What is the name of the disease caused by Taenia?

Cysticercosis

How does a person acquire Cysticercosis?

ingestion of taenia eggs contained in contaminated water with animalfeces, lesions anywhere in body

What is it called if Taenia infection goes to the brain?

Neurocysticercosis

Cysticercosis symptoms (3)

1. cystic brain lesions
2. hydrocephalus
3. seizures

How does Cysticercosis look like on head CT?

Swiss cheese on head CT

Typical person who gets Cysticercosis (2)

1. Immigrant

2. Farmer

Is it ingestion of eggs, cysts, or larvae that causes Cysticercosis (Taenia)?

Eggs only

What does ingestion of Taenia cysts or lavae cause?

Taeniasis - usually asymptomatic, but may cause GI problems or malabsorption

How do you treat Cysticercosis?

Treatwith Praziquantel, but add Albendazole if Neurocysticercosis

What type of parasite is Diphyllobothriumlatum?

1. Fish tapeworm

2. Cestodes

How do you get Diphyllobothriumlatum?

Eating undercooked fish

Features of Diphyllobothriumlatum (3)
1. causes diarrhea
2. B12 Cobalamin deficiency
3. Megaloblastic anemia
Unique feature of Diphyllobothrium latum

largesttapeworm that can grow up to 10 m long

How do you diagnose Diphyllobothrium latum?

Proglottid segments seen on stool O&P

How do you treat Diphyllobothrium latum? (2)

1. Treat with Praziquantel or
2. Niclosamide

What is the host of Echinococcusgranulosus?


1. Definitive

2. Intermediate

Dogs are definitive host


Sheep are intermediate host

How do you get Echinococcusgranulosus?

Ingest eggs from contaminated food or water with dog feces

How does Echinococcusgranulosus appear on CT?

Egg shell calcifications in cyst on liver

What type of cysts do you see on Echinococcusgranulosus?

Hydatid cysts in liver cyst

What is a possible complication of Echinococcusgranulosus?

Liver Cysts rupture cause an anaphylactic reaction and acute abdomen

Do you see Eosinophilia with Echinococcus granulosus?

Yes

What type of parasite is Taenia genus? (2)

1. Cestodes
2. Tape worm

What type of parasite is Echinococcus granulosus?

1. Cestode

2. Tape worm

What type parasite is Schistosoma spp?

1. Trematode

2. Flukes

What type of parasite is Clonorchis sinensis?

1. Flukes

2. Trematodes

What type of parasite is Paragoniumus westermani?

1. Flukes

2. Trematodes

What is another name for Schistosoma infection?

Swimmer's itch

How does Schistosoma enter the person's body?

Penetrate skin in aquatic environment

What is the immediate host of Schistosoma?

Snails

Pathogenesis of Schistosoma

Blood => mature in liver => migrate against portalblood flow

How does Schistosoma mansoni appear on stool O&P?

Large lateral spine

How does Schistosoma japonicum appear on stool O&P?

small spine on stool O&P (if spine even visible)

Schistosoma mansoni symptoms (3)

1. Portal hypertension

2. Cirrhosis

3. Jaundice

Schistosoma japonicum symptoms (3)

1. Portal hypertension

2. Cirrhosis

3. Jaundice

How does Schistosoma haematobium appear on stool O&P?

Large terminal spine seen on stool O&P

Schistosoma haematobium symptoms (2)

1. Hematuria

2. Bladder cancer

Do Schistosomas migrate with or against portal blood flow?

Against

How do you treat Schistosomas?

Praziquantel

Another name for Clonorchis sinesis

Chinese liver fluke

What is the intermediate host of Clonorchis sinensis?

Snails

How do you get Clonorchis sinensis?

Uncooked fish (sushi)

Pathogenesis of Clonorchis sinensis

Snails => uncooked fish (sushi) => larvae in biliarysystem => biliary tract fibrosis, pigmented gallstones, cholangiocarcinoma

Clonorchis sinensis symptoms (3)

1. Biliary tract fibrosis

2. Pigmented gallstones

3. Cholangiocarcinoma

How do you diagnose Clonorchis sinensis?

Operculated eggs on O&P

How do you treat Clonorchis sinensis?

Praziquantel

Paragoniumus westermani is what type of parasite?

Lung fluke

Paragoniumus westermani intermediate host

snails

How do you get Paragoniumus westermani?

Raw or undercooked crab meet with larvae ingestion

How do you diagnose Paragoniumus westermani?

Operculated eggs on stool O&P

How do you treat Paragoniumus westermani?

Praziquantel

Symptom of Paragoniumus westermani

Chronic cough with bloody sputum