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30 Cards in this Set

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3 Immunosuppressants that Inhibits IL-2 transcription or signal transduction and thus inhibit T cell activation

*Cyclosporine (binds cyclophilin to inhib. calineurin)




*Tacrolimus (binds FKBP to inhib. calcineurin)




*Sirolimus (binds FKBP to inhibit MTOR)

Antibodies....




1) Ab against CD20


2) Ab against VEGF


3) Ab against Gp 2b/3a


4) Tyr. Kinase inhibitor against bcr-abl fusion protein and c-kitt


5) Ab against RANK-L to inhibit Clasts

1)Rituximab




2) Bevacizumab




3) Abciximab (anti-plt used for prophylactively in pts undergoing angioplasty)




4) Imatinib




5) Denosumab

Directly inhibit thrombin

Argatroban & Bivalirudin




*used in HIT pts

Directly inhibit factor Xa

ApiXaban & RivaroXaban




*used for DVT & PE prophylaxis and Stroke prophylaxis in A-fib pts.


*unlike warfin, no lab monitoring necessary

Irreversibly Inhibit ADP receptor to prevent insertion of Gp2b/3a and thus inhibits plt cross-linking

Clopidogrel & Ticlopidine




*Used in combo w/ ASA after MI or stroke


*Ticlopidine used in ASA/Clopidogrel allergic

Increase cAMP in plt by inhibiting Phosphodiesterase III.




*Leads to inhibition of plt aggregation and direct vasodilation!*

Cilostazole and Dipyridoamole




*used for PAD or in combo w/ ASA after MI or stroke

S-phase specific agent that inhibits ribonucleotide reductase to decrease DNA Synthesis

Hydroxyurea




*also increase HbF and is thus used in sickle cell pts

___ inhibits topo II to increase DNA degradation, while ____ inhibits topo I to prevent DNA unwindering.

Etoposide = Topo II (used in testicular cancer!)




"-Tecans" = Topo I

What 4 drugs cross-link DNA?

Cyclophosphamide


Nitrosureas ("mustines")


Busulfan


Platinums (used in testicular cancer)

What antitumor ABXes intercalate DNA and damage it via free radical production?

Dactinomycin (childhood tumors)


Doxo- and Daunorubcin


Bleomycin (used in testicular cancer)

Block Leukotriene receptors to prevent neutrophil chemotaxis (Leuko B4) and increase bronchial tone (LTC/D/E4)

Zafilukast & Montelukast




*asthma prophylaxis in kids

Inhibits Lipoxygenase to block the production of leukotreines

Zileuton




*asthma prophylaxis

↓ Plt aggregation


↓ bronchial tone


↓ vascular tone


↓ uterine tone




*Produced by COX1/2 and thus inhibited by ASA, NSAIDs, and Acetominophen

Prostacycline (PGI2)




*think "Plt Gathering Inhibitor"

↓ Bronchial tone


↓ Vascular tone


↑ Uterine Tone


↑ Gastric Mucus production




*Produced by COX1/2 and thus inhibited by ASA, NSAIDs, and Acetominophen

Prostaglandins (PGE2 and PGF2a)

↑ Plt Aggregation


↑ Bronchial Tone


↑ Vascular Tone




*Produced by COX1/2 and thus inhibited by ASA, NSAIDs, and Acetominophen

Thromboxane (TXA2)




*Think of as the Anti-Prostacyclin

Inhibits Lipolysis in fat to decrease hepatic VLDL production

Niacin




*used to ↑ HDL

Prevents Cholesterol absorption at SI brush border leading to an ↑ of LDL receptors on Liver

Ezetimibe




*used to ↓ LDL

Upregulates Lipoprotein lipase to ↑ TG clearance and activates PPAR-alpha to increase HDL synthesis

Fibrinates




*Main use is to ↓ TG to prevent acute pancreatitis

What meds need to be given to a pt w/ Acute CHF exacerbation (ie SOB, foaming at mouth, extreme edema)?

** NO LIP **




NO (↓ preload to alleviate pulm. edema)


Oxygen (correct hypoxemia)


Loop diuretic (for pulm and periph edema)


Inotropic Agent (Dobutamine)


Position in Upright position to pool blood in legs

Close K+ channels leading to depolarization of Beta-cells to increase Insulin release (via Ca2+ influx)

Sulfonyureas (Glyburide, Glimepride, Glipizide)

↑ Insulin senstivity by binding to PPAR-gamma nuclear transcrip. regulator to cause an increase in Adiponectin

TZD's (Pioglitazone & Rosiglitazone)

Increase Insulin release and decrease glucagon

GLP-1 Analogs (Exenatide & Liraglutide)




DPP-4 Inhibitors ("-Gliptins")

3 drugs for Acute Closed Anlge Glaucoma

1) Beta-Blocker (Timolol)




2) Alpha-2 Agonist (Apraclonidine)




3) M3 Agonist (Piolcarpine

5 drugs to treat Parkinsons

** BALSA **




*Bromocriptine (erogot) or Pramipexole - dopamine agonists


*Amantidine - ↑ endogenous dopamine


*L-Dopa/Carvidopa - converted to dopamine in CNS


*Selegine (MAOI) or Enta/Tolcapone (COMTI) - prevent dopamine breakdown


*Antimuscarinic (Benztropine) - for tremor/ridgitiy

2 classes of drugs that block the reuptake of Norepinephrine and 5-HT

SNRI's (Venlafaxine, Duloxetine)




TCA (-ipramine, -iptyline)

2 drugs that inhibit Desmolase and thus are useful in the trx of PCOS to prevent hirsuitism

Ketoconazole




Spironolactone

5-alpha reductase Inhibitor

Finasteride




*used to male-pattern baldness & BPH

Competitive inhibitor of androgens at testosterone receptor

Flutamide




*prostate cancer

Antagonist at estrogen receptor in hypothalamus to prevent negative feedback and thus ↑ LH and FSH

Clomiphen




*used for PCOS and infertility

What 4 drugs are used to treat Pulmonary HTN?

*Bosetan/Ambrisetan (Endothelin-1 inhibitors)


*PG (dilates pulm. BV)


*Sildenafil (relaxes pulm vasc. smooth mm)


*Nifedipine (CCB)