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23 Cards in this Set
- Front
- Back
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What is the aka name for kaposi's sarcoma herpes virus?
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Kaposi’s Sarcoma Herpes Virus (KSHV)
• aka Human Herpes Virus – 8 (HHV‐8) • |
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HHV- 8 aka KSHV...
a. type of virus genome b. family? c. what does it cause? |
1. Enveloped, DNA virus from
2. the Herpesviridae family 3. Causes Kaposi’s Sarcoma only when immuno deficiency occurs• due to latency |
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In HIV+ pts what variant of kaposi's sarcoma will you see usually?
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AIDS- KS with death in weaks to months
- same lesions as other "indolent lesions" usually on the legs - not malignant |
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1. CMV in immunocompromised appears with CD4 count of?
2. For AIDs pts what is MC symptom? |
1. <50
2. - reitnitis, white fluffy retinal infiltrates |
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Organ transplants with CMV?
Gold standard for CMV diagnosis? |
primary due to donor having CMV+ mostly GI tract symptoms
- PCR for antibodies and viral DNA |
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Explain why crytposporidium is so dangerous to immunocompromised?
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autoinfective and not self limiting, which can lead to diarrhetic fluid loss of >10 liters/day
- it infects the entire GI tract which can lead to liver inflamation/cirrhosis |
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crytposporidium dx?
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Gold standard- acid fast staining for stool for oocytes
Immunoassays (direct fluorescence, DFA) |
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acid fast stain what is it?
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crytposporidium parvum
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Acid fast what is it?
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crytosporidium parvum
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acid fast what is it?
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c. parvum
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what do arrows and arrow head point to in DFA analysis
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head- g. lamblia
arrows- c. parvum |
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Three types of t. gondii infections and most common?
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1. toxoplama encephalitis- MC
2. pulmonary toxoplamosis 3. toxoplasmosis chorioretinitis |
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Invasion of aspergillus into body come from how and what form?
What type of diagnosis study is done for aspirgilius? |
1. aerial hyphae with characteristic conidia form in longs in immunocompromised pts
2. via sputum, biopsy (rarely blood) • KOH or calcofluor white for sputum • biopsy stain with Gomori methenamine silver or Grocott stain |
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Cryptococcus neoformans has what for virulence factors?
Diagnose with what? |
large polysaccharide capsules, produces urease and laccase (produce melanin)
= india ink stain |
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pigeon feces think?
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cryptococcus
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MCC of meningitis in HIV-infected patients
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crytococcal meningoenchephalitis
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cryptococcus
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dimorphic, incidence varies, in soil Mississippi, Missouri & Ohio river valleys; in bat & bird fecal matter
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histoplasma capsulatum
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histoplasma capsulatum for diagnosis you look for?
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facultative intracellular within macrophages
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Seen in SW US
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coccidioides immitis
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coccioides immitis
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two stages of pcp and what does each stage do?
How do you diagnose pcp? What are the stains? |
1. trophozoite stage- metabolically active
2. cyst stage- resistant to environment Diagnose with lavage and staining with Giemsa or ironhematoxylin Tissue biopsy gomori's methenamine silver stain for cysts |
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Germ tube test used for?
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Candida
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