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11 Cards in this Set
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B2 AGONIST:
B2 IN THE LUNGS will causes bronchodilation |
Albuterol: used for acute attacks
Salmeterol and Formoterol: longer acting hence used as prophylsis of asthma --> can cuase arrthymia and tremors. |
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Methyxantinte
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Theophylline
Theo has high energy. Mech: Blocking Adenosine and inhibiting phosphodiesteresae allowing increase in CAMP via decrease in hydrolyzing camp (same effect as B2 agonist which is a Gs) Use: ASthma, but limited due to narrow tx index Tox: cardiotox and neurotox: specifically seizure (main) and tachycardia (no QT though). vomit too. abdom pain Metabolized by p450, no hep problems |
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Muscarinic antagonist
M recetors on the lung 2, 3 --> bronchoconstriction. |
Ipratropium
Mech: competitivie antag of muscuranic receptors (competes with Ach) prevents bronchoconstriction Use: asthma and COPD (tiotropium too, longer lasting) |
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Corticosteroids
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Beclomethasone and Fluticasone
Mech: Inactivate Nf-kb which will inhibit the transcritpton factor for TNF -Alpha and all cytokines related to inflmmation. Use: First line tx of CHRONIC asthma, low dose inhalant Tox: Decrease in immunity = oral candidis **If High dose: increase in intraocular pressure and growth retardation. |
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Antileukotrienes: blockers
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Montelukast, zafirlukast
-lukast Mech: Block leukotrienes, really good for asprin-asthma since asprin will acethylate tissue proteins causing hapten which will cause an immune response. |
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antileukotrienes: pathy inhibotors
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Zileuton: stops 5-lipoxygenase pathway hence no conversion of archnoitc acid to leukotrienes.
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Omalizumab
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Mech:Monoclonal antibody to IgE, prevents this guy from binding to FceRI via binding the free IgEs = hence stops mast cell activation.
Use: Asthma resistant to Corticosteroid (inhaled betacholsol and fluticsone), and B2 agonist long act (salmonol and formoterol) |
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Methacholine
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mech: Muscuraic agonist that causes bronchoconstriction via m2,m3
Use: to dx asthma via provoking it |
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Bosentan
Endothelin binds to endothelin 1 to cause vasoconstriction. |
Use: Tx pul arterial HT by antagonizing endotheliun -1 receptors allowing for a decrease in pul resistance.
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Varienicline
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Mech: partal agonist to alpha4beta2 nicotinic ach receptors --> it will release only some dopamine (little reward so a reduction compared to nicotine) and decresae in withdrawl effects.
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Cromyln and Nedocromil
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They will decrease the release of mast cell degranulation hence decrease in asthma
Use: to prevent attacks or in acute attacks, great in asprin asthma just like |
