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19 Cards in this Set
- Front
- Back
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what is the target cell for the HIV virus
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CD4 T cells (T helper cells)
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what plays a central role in regulation of the immune system by affecting the maturation and proliferation of beta lymphocytes, T lymphocytes, NK cells and macrophages and monocytes
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CD4 T cells
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what is the binding glycoprotein that attaches to CD4 t cells
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gp120
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people who are immune to HIV lack what receptor on the T cells
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chemokine receptor CCR5
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what pierces the membrane of the target cell to mediate virus fusion
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gp41
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an infected cell with HIV can bind with the CD4 surface protein of uninfected T4 lymphocytes and fuse together to form...
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syncytium
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how many strands of RNA are in the HIV virus
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2
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what is the name of the inner membrane protein of the viral envelope of HIV by fatty acid acylation
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P17
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what enzyme of HIV consists of a DNA polymerase and an RNase H to make DNA from viral RNA
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reverse transcriptase
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what enzyme assits in inserting the viral DNA into the host's genome
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integrase
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what enzyme of HIV is a proteolytic enzyme which cuts the virus's proteins out of a long polypeptide
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protease
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the lipids of the virus envelope are from...
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T4 plasma membrane
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what is required for the integration of HIV provirus
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activation
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where in the body would you find high concentrations of CD4 positive T cells
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lymphoid regions and thymus
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what are the three structural genes of HIV and what do they code for
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GAG: Codes for core proteins POL: enzymes (reverse transcriptase)
ENV: envelope protein (GP120) |
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what are the three regulatory genes of HIV and what is their function
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TAT: potent stimulator of viral protein replication
REV: allows varying amount of regulatory or structural proteins to be made NEF: positive virulence factor (maturation) |
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which subtype of HIV is predominate in North america and Western Europe
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B subtype
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how does the drug AZT work
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recognized as a thymine, but can't form a covalent bond with the next nucleotide
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what is the name of the drug that is a protease inhibitor used as a protease inhibitor
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saquinavar
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