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20 Cards in this Set

  • Front
  • Back
burr cell?
milder form of acanthocyte

uremia, pyruvate kinase deficiency, microangiopathic hemolytic anemia, mechanical damage
what is danazol? Clomiphene? Medroxyprogesterone? Mifepristone? Flutamide? Finasteride?
danazol - synthetic androgen for tx of endometriosis & hereditary angioedema

clomiphene - antiestronge inferfering w/neg feedback on hypothal & pituitary, increases GnRH synth, used for infertility

Medroxyprogesterone - progesterone only contracept, IM q12 wks

Mifepristone - steroid w/anti-progestin & anti-glucocorticoid efects, primarily an abortifacient

flutamide - antiandrogen inhibits binding to testosterone receptor

finasteride - 5alpha reducatase inhibitor
E coli that does not ferment sorbitol nor produce glucoronidase?
E. coli O157:H7
bacteria producing toxins that…

-activate adenylate cyclase?

-activate guanylate cyclase?

-inactivate EF2?

-disrupt cytoskeleton?
active adenylate cyclase - b. pertussis (pertussis toxin), B. anthracis (edema factor), ETEC (heat labile), campylobacter, bacillus cerus (heat labile) & v cholera

activate guanylate cyclase - ETEC (heat stable), Yersinia enterocolitica

inactivate EF2 - corynebacterium diphtheriae, Pseudomonas aeruginosa (ADP-ribosylation)

disrupt cytoskeleton - C difficile (toxin B, cytotoxin)
drug w/partial agonist & weak antagonist activity at mu receptors?
patient with HIV, heroin, or sickle cell dz develops nephrotic syndrome?
Focal Segmental Glomerulosclerosis

MC in hispanics & African Americans
patient w/lupus gets nephrotic syndrome?
Membranous Nephropathy
MCC nephrotic syndrome in caucasian adults?
Membranous Nephropathy
nephrotic syndrome w/hep B, C, or solid tumors?
Membranous Nephropathy
or type 1 membranoproliferative (underneath endothelial)
Nephrotic syndrome w/some drugs? (NSAIDs, penicillamine)
Membranous Nephropathy
holosystolic murmur w/thrill? Left sternal border
location of immune complex deposition and corresponding glomerulonephropathy?
below foot processes, above endothelium - Membranous

within endothelium - Type II emmbranoproliferative (tram track)

below endothelium - Type I membranoproliferative
how to think about the 6 nephrotic dz in groups of 2?
1st group - foot processes, Minimal Change (kids after infection, associated w/Hodgkins) & focal segmental (HIV, heroin, sickle cell)

Immune complexes - membranous & membranoproliferative

then diabetes & amyloid - diabetes is deposition of hyaline arterosclerosis, get big blebs in certain parts, tx w/ace i
-amyloid get deposits in mesangium, apple green birefringence
cola colored urine?
Post strept glomerular nephritis
transmural inflammation of arterial wall w/fibrinoid necrosis?
polyarteritis nodosa (PAN), associated w/hepatitis B in 10-30% cases

this vasculitis can resemble Churg Strauss by histology (the one w/eosinophilia & asthma), but Churg Strauss characteristically has granulomas & eosinophilic necrosis
tubocurarine vs succinylcholine?
tubocurarine is NON-depolarizing NMJ blockade
what drives respiration and where is it sensed?
normally CO2 centrally

in prolonged hypercapnia O2 in peripheral chemoreceptors (carotid bodies)
what does urine chloride help with?
assessing volume status…weird question
what is phentolamine? What is phenoxybenzamine?
phentolamine - reversible, competitive, non-specific alpha-adrenergic antagonist
-used for catecholaimine induced hypertensive crisis

phenoxybenzamine is a nonselective, irreversible alpha1 & alpha2 receptor antagonist
sensory innervation of medial vs lateral forearm?
medial - branch of ulnar nn

lateral - branch of musculocutaneous nn