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36 Cards in this Set
- Front
- Back
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Normal function of Alpha1 receptors
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vasoconstriction
ejaculation contraction of bladder neck and prostate |
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Normal function of Beta 1 receptors
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Heart (increases rate, force of contraction, velocity of conduction in AV node)
Kidney (renin release) |
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Normal function of Beta 2 receptors
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Bronchial dilation
Relaxation of uterine muscle Vasodilation Glycogenolysis |
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Normal function of Dopamine Receptors
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Dilates renal blood vessels
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Normal function of Muscarinic receptors
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Slows heart rate
Increases gastric secretions Emptying bladder and bowel Focuses eye for NEAR vision Constricting pupil Contracting bronchial smooth muscle Erection in men Increases saliva |
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Normal function of Nicotinic receptors
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Paralysis for anethesia (SUCCINYLCHOLINE)
Sleep Anxiety Processing pain Cognitive function Chemical warfare |
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What is the MOA of Bethanechol
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selective agonist at muscarinic cholinergic receptor
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What are the therapeutic uses of Bethanechol
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Urinary retention
Gastrointestinal uses |
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What is the MOA of Atropine
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muscarinic antagonist (receptor blockade)
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What is the MOA of Tolterodine
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muscarinic antagonist (used for Overactive bladder)
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What is the MOA of Ipratopium
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muscarinic antagonist
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What is the MOA of Ipratopium
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muscarinic antagonist
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What is the MOA of Succinylcholine
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It is a depolarizing neuromuscular blocker that works on the nicotinic receptors preventing acetylcholine to activate it through depolarization
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What is the therapeutic use of Succinylcholine
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muscle relaxation during intubation (ultra short-acting peak at 1 min fades in 4-10)
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Adverse effects of Succinylcholine
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Malignant hyperthermia
Postoperative muscle pain Hyperkalemia Prolonged apnea |
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What is the MOA of Albuterol
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Beta 2 activation (direct receptor binding)
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What is the MOA of Dopamine
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Activation of peripheral dopamine receptors (dilates vasculature of kidney allowing increased blood flow in kidney failure)
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What is the MOA of Epinephrine
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Activates Alpha 1&2 and Beta 1&2 (lots of therapeutic and adverse effects
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What is the therapeutic uses of Epinephrine
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-EpiPen
-Elevates blood pressure -AV block reverse -Dilation of bronchioles in asthma |
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What are the adverse effects of Epinephrine and Norepinephrine
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Angina pectoris
Hypertensive crisis Necrosis following extravasation Dysrhythmias |
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What is the MOA of Norepinephrine
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Activates Alpha 1&2 and Beta 1
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What is Norepinephrine used for
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hypotensive state
cardiac arrest |
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What adverse effect does Epinephrine have that norepinephrine doesn't
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Hyperglycemia (because E works on B2 and NE doesn't)
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What is Dopamine's receptor specificity
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LOW DOSE : dopamine receptors
MODERATE DOSE: dopamine and beta 1 receptors VERY HIGH DOSE: Alpha1, Beta 1 and dopamine receptors |
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What is the MOA of Alfuzosin
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adrenergic antagonist that is an alpha receptor blocker
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What is the MOA of Phenoxybenzamine
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adrenergic antagonist that is an alpha receptor blocker
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What is the MOA of Propranolol
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individual beta receptor blocker on both beta 1 and beta 2
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What is the MOA of Metoprolol
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individual beta receptor blocker on both beta 1 and beta 2
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What are the adverse effects of beta-adrenergic antagonists II
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-bradycardia
-AV heart block -Heart failure -rebound cardiac excitation -Inhibition of glycogenolysis -bronchoconstriction |
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What are contraindication of beta-adrenergic antagonists II
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severe allergy
diabetes cardiac, respiratory & psychiatric disorders |
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What is the MOA of Clonidine
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selective activation of alpha 2 receptors in the CNS thus decreasing sympathetic outflow to blood vessels and the heart
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What are the therapeutic uses of Clonidine
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Hypertension
Severe pain |
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What are the adverse effects of Clonidine
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-Don't use in pregnancy
-Rebound hypertension -Drowsiness -dry mouth (xerostomia) -Others (constipation, impotence, gynecomastia) |
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What is the MOA of Methyldopa
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causes alpha 2 activation by being taken up into brainstem and being converted into an alpha 2 agonist
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What are the therapeutic uses of Methyldopa
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Hypertension
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What are the adverse effects of Methyldopa
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hemolytic anemia
hepatotoxicity others (dry mouth, sexual dysfunction, orthostatic hypotension) |
