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17 Cards in this Set
- Front
- Back
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What effect does neostigmine have on ACh?
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prolongs the effect of ACh (distracts AChE)
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What are the sites of action for physostigmine?
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all cholinergic synapses
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is physostigmine lipid soluble? why is this clinically important?
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yes; it crosses the BBB
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what are the therapeutic uses of physostigmine?
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miotic; treatment of glaucoma; reverse anti-muscarinic effects
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Is neostigmine lipid soluble?
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no
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is pyridostigmine lipid soluble?
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no
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which AChE inhibitors would be used to treat myasthenia gravis?
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neostigmine and pyridostigmine
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What is the clinical usefulness of Edrophonium?
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short acting, diagnostic for myasthenia gravis, whether neostigmine dose is too high or low
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if a patient on neostigmine for myasthenia gravis is experiencing weakness which becomes worse with edrophonium, is the neostigmine dose too high or low?
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too high
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how can too much neostigmine produce muscle weakness?
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can't get rid of ACh
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what is the mechanism of irreversible AChE inhibitors?
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irreversibly phosphorylate AChE
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What is the therapeutic use for irreversible AChE inhibitors?
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last resort for glaucoma
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some insecticides have the same effect as __________
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AChE inhibitors
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What is the difference between neostigmine and organophosphates?
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neostigmine is reversible
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how would you treat a patient exposed to sarin?
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atropine (muscarinic blocker)
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What is the clinical use of 2-PAM?
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organophosphate poisoning
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What effect will 2-PAM have on neostigmine overdose?
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no effect or make it worse
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