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19 Cards in this Set
- Front
- Back
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Bioavailability
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Extent and rate of a drug into the systemic circulation
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Drug Distribution
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Degree to which a drug distributes beyond serum or plasma
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Calculate Drug Distribution (Vd)
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Dose X F / Cpo
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Do all drugs have fixed half life?
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No about 90% do
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What is the usual determination of peak concentration?
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It is in serum or plasma (Cp) not whole blood
Dont know conc. of drug at the site of action Should relate plasma conc. (Cp) to pharmacological response |
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Bioavailability Value (F)
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Fraction of drug absorbed
(F) Between 0-1 X 100 = % IV is 100% F = AUC PO / AUC IV |
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Acutal Amount of Drug Absorbed
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Dose X F (bioavailability)
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Plasma Concentration
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Cp
Extend line of graph to Y axis and that is plasma conc. at time 0 |
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Volume of Distribution
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Amt. of drug in body (Dosage X F)/Cp0 (Plasma Conc at time 0)
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150 ug = mg
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0.15 mg
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Loading Dose
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Volume of distribution X Cp/F
If Vd is given in l/kg then need to multiply by body weight |
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First Order
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Change in pharmacokinetic reate reaction PROPORTIONAL to dosage
FIXED half life |
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Zero Order
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Change in Pharmacokinetic reate reactions NOT PROPORTIONAL to dosage
Ex: alcohol NO fixed half life |
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Steady State
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Only applies to drugs in first order kinetics
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One Compartment Model
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No curve to the graph
Body viewed as single comparment (water compartment) based on drug distribution Usually water soluble drug low Vd |
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Two compartment Model
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Body viewed as 2 compartments based on distribution, blood flow, lipid solubility
Lipid Soluble Drugs 1st phase/alpha distribution when it is in central compartment 2nd phase/beta elimination use this for calculating Cpo |
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Half Life Percentages
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Time 0: 100% & 0 %
Time 1: 50% & 50% Time 2: 25% & 75% Time 3 12.5% & 87.5% Time 4: 6.25% & 93.75% Time 5: 3.12% & 96.88% |
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Drug Clearance
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Volume of biologic fluid from which a drug is removed per unit of time
t 1/2 = 0.693 X Vd / CL total |
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Creatine clearance is proportional to what?
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Glomerular filtration
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