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5 Cards in this Set
- Front
- Back
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What are the monoamine systems and what do the neurotransmitters NE, 5-HT, and DA do?
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Monoamine systems in limbic system and upper brainstem.
NE: focused attention, elevated energy, motivation to win reward Serotonin, 5-HT: mood, emotion, sleep, appetite, obsessional thoughts Dopamine, DA: joy of life, pleasure, attention, euphoria |
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Other receptors get affected by ADs also and are associated with AEs: 5-HT3, 5-HT2, H1, muscarinic, alpha1 -- explain.
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5-HT3 agonist and antagonist: gut, agonism -> transient N/V/D, antagonism -> anti-emetic
5-HT2 agonist: insomnia, anxiety, akathesia (restlessness), sexual dysfunction H1 antagonist: weight gain (appetite), sedation muscarinic antagonist: constipation, dry mouth, drowsiness, confusion alpha1 antagonist: orthostatic hypotension |
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What are the DSM-IV TR criteria for diagnosing depression (need 5 or more sx's)?
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Sleep: hypersomnia, insomnia
Interest: DEPRESSED MOOD or ANHEDONIA (must have 1) Guilt: worthlessness Energy: fatigue Concentration: difficulty concentrating Appetite: weight changes Psychomotor: motor retardation/agitation Suicide |
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What are the different etiologic hypotheses explaining depression?
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Stress diathesis: biologic predispositions
Biological model: drugs manipulate NTs Cathecholamine: depletion of 5-HT, NE (drug-induced by reserpine) Dysregulation: dysreg bw 5HT and NE |
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When should you use psychotx? ECT? How does ECT work?
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Psychotherapy for mild to moderate depression (4-6 weeks to work)
ECT for severe depression, downreg beta-receptors to give more rapid onset, okay in pregnancy and elderly |
