Pharm Drugs Used In Gi Disorders

Front 1

Two types of Antacids and their clinical use

Back 1

Magnesium Hydroxide, and aluminum hydroxide, used to treat GERD and peptic ulcers

Front 2

Side effects of antacids

Back 2

Magnesium Hydroxide has a laxative effect, anf Aluminum Hydroxide has a constipation effect

Front 3

H2 receptor antagonists used for PUD, GERD, and nonulcer dysplasia

Back 3

Cimetidine, ranitidine, and famotidine, and nizatidine. (use is being supplanted by the safer PPI's)

Front 4

Serious side effect of Cimetidine

Back 4

is an inhibitor of CYP450 enzymes and it reduces hepatic blood flow

Front 5

Proton pump inhibitors, and their clinical use

Back 5

Omeprazole, esomeprazole, lansoprazole, etc... weak bases that migrate into parietal cell canniliculi, where they multiply 1000 fold and inactivate parietal cell H+/K+/ATPase transporter

Front 6

Duration of action of the PPI's and amount of tiime required to achieve full effectiveness

Back 6

24 hours, may take 3-4 days to reach max effectiveness

Front 7

Clinical uses for PPI's

Back 7

GERD, PUD, nonulcer dysplasia, as well as stress related mucosal bleeding. also for Zollinger ellison syndrome

Front 8

Adverse effects of PPI's

Back 8

diarrhea, abdominal pain, and headache. chronic treatment may result in hypergastrinemia, also may reduce vit B12absorption, and drugs that requires acidity for absorption. Ketoconazole and digoxin

Front 9

What is an aluminum sucrose sulfate that polymerizes in the acid environment of the stomach, bonding to injured tissue, providing a protective coating over ulcer beds

Back 9

Sucralfate. used to help heal peptic ulcers, and reduce recurrance.

Front 10

Number of doses required per day of Sucralfate

Back 10

4

Front 11

An analog of PGE1 that increases mucosal protection and inhibits acid secretion

Back 11

Misoprostol

Front 12

Clinical use of Misoprostol

Back 12

reduce risk of ulcers in chronic users of NSAIDS

Front 13

Drug with multiple uses that coats ulcerated tissue, stimulates mucosal protective mechanisms, and sequesteration of enterotoxins

Back 13

colloidal bismuth. causes feces to turn black

Front 14

Treatment of choice for H Pylori associated peptic ulcers

Back 14

PPI, Clarithromycin, and amoxicillin (metronidazole if penicillin allergy)

Front 15

Dopamine D2 receptor antagonists that promote gastric motility

Back 15

Metoclopramide and domperidone,

Front 16

Other clinical uses of Metoclopramide and domperidone,

Back 16

block D2 receptors in the area prostrema, serving as antiemetics after surgical anasthesia, and chemotherapy treatments

Front 17

toxicities of Metoclopramide if used chronically

Back 17

Parkinson's symptoms, other extrapyrimidal effects, and hyperprolactinemia.

Front 18

Antibiotic that produces increased motility by stimulating motilin receptors

Back 18

Erythromycin

Front 19

Mechanism of action of laxatives

Back 19

irritant or stimulant action on bowel wall, bulk forming action on stool with reflex contraction of the bowel, and softening of hard or impacted stool, lubrication, easing passage

Front 20

Opioid derivative Antidiarrheal agents

Back 20

dyphenoxylate and loperamide, meperidine analogs with very weak analgesic effects

Front 21

Naturally occuring hydrated magnesium aluminum silicate, combined with pectin, to absorb bacterial toxins and fluid, resulting in less liquidity of stools

Back 21

Kaolin

Front 22

Side effects of the antidiarrheal agents

Back 22

constipation, and lessening of absorption of other drugs

Front 23

Drugs used for IBS, that are antispasmodics that relieve abdominal pain

Back 23

dicyclomine and hyoscyamine

Front 24

5_HT3 antagonist that is used for women with severe IBS with Diarrhea, but due to its severe complications, its use is restricted

Back 24

Alosetron, can cause constipation

Front 25

Antiemetic drugs:

Back 25

D2 receptor antagonists, H1 histamine blockers, antimuscarinic drugs, dexamethasone, and the 5-HT3 antagonists, and Aprepitant, a NK1 receptor blocker