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23 Cards in this Set

  • Front
  • Back
Adrenergic Agents (Sympathomimetics)
Pr - phenylephrine (Neo-Synephrine)
MOA - Stimualte SNS directly/indirectly
PU - nasal congestion, hypotension; mydriasis during Ophth exam.
AE - Tachycardia, hyypertension, dysrhythmias, CNS excitation, seizures, dry mouth, nausea, vomiting, anorexia.
Adrenergic Block Agents
Pr - prazosin (Minipress)
MOA - inhibit SNS
PU - hypertension, dysrhythmias, angina, heart failure, BPH, narrow angle glaucoma
AE - orthostatic hypotension, reflex tachycardia
Cholinergic Agents (Parasympathomimetics)

Direct Acting
bethanechol (Urecholine)
MOA - activate PNS directly/indirectly.
PU - glaucoma, urinary retention, myasthenia gravis, Alzheimer's
AE - profound salivation, increased muscle tone, urinary frequency, bronchoconstriction, bradycardia
Cholinergic Blocking Agents
Pr - atropine
MOA - inhibit PNS
PU - peptic ulcers, irritable bowel syndrome, mydriasis and cycloplegia during eye exam, bradycardia, preanesthetic, asthma
AE - tachycardia, CNS stimulation, urinary retention, dry mouth, dry eyes, decreased sweating, photophobia
Antidepressants - SSRI
Pr - escitalopram oxalate (Lexapro)
MOA - selective serotonin reuptake inhibitor
PU - Anxiety and depression, panic disorders
AE - dizziness, nausea, insomnia, somnolence, confusion, seizures
OD - symptoms serotonin syndrome
Pr - lorazepam (Ativan)
MOA - potentiates GABA, inhibititory
PU - anxiolytic, preanesthetic, status epilepticus
AE - amnesia, weakness, disorientation, ataxia, sleep disturbance, BP change, blurred vision, double vision, nausea, vomiting
Nonbenzodiazepine, Nonbarbituate CNS Depressants
Pr - zolpidem (Ambien)
MOA - GABA mediated CNS depression
PU - short-term insomnia management
AE - daytime sedation, confusion, amnesia, dizziness, depression, nausea, vomiting
OD - flumazenil (Romazicon) as benzo receptor antagonist
Tricyclic Antidepressants
PR - imipramine (Tofranil)
MOA - blocks reuptake of Serotonin and norepinephrine
PU - clinical depression, intractable pain, anxiety disorders, withdrawal symptoms from ETOH and cocaine.
AE - sedation, drowsiness, blurred vision, dry mouth, cardio symptoms such dysrhythmias, heart block, and extreme hypertension
OD - activated charcoal, resp cart; *avoid NRE or Serotonin, may produce toxicity
Selective Serotonin Reuptake Inhibitor
Pr - Sertraline (Zoloft)
MOA - inhibits reuptake of serotonin
PU - depression, anxiety, OCD, panic, PMS dysphoric disorder, PTSD, social anxiety
AE - agitation, insomnia, headache, dizziness, somnolence, fatigue, seizure, suicidal ideation, mania, hypomania
Monoamine Oxidase Inhibitor
Pr - phenelzine (Nardil)
MOA - inhibition of MOA, intensifies NRE
PU - depression not responsive to other antidepressants, panic disorder
AE - constipation, dry mouth, orthostatic hypotension, insomnia, nausea, loss of appetite
OD - seizures, respiratory depression, circulatory collapse, coma
Atypical Antidepressants
Serotonin-norepinephrine Reuptake Inhibitor (SNRIs)
Drugs for bipolar disorder
Pr - lithium (Eskalith)
MOA - influences release, synthesis, and reuptake of dopamine, NRE, serotonin
PU - stabilization of mood
AE - dizziness, fatigue, short-term memory loss, increased urination, nausea, vomiting, loss of appetite, abdominal pain, diarrhea, dry mouth, muscular weakness, slight tremors.
OD - hemodialysis
Drugs for ADHD
CNS stimulants
Pr - methylphenidate (Ritalin)
MOA - activates reticular activation system--release of NRE, dopamine, serotonin
PU - reduced impulsiveness, hyperactivity, disruptive behavior
AE - non-ADHD = nervousness, insomnia. ALL = risk for irregular heart beat, high BP, liver toxicity. SCHEDULE II
Conventional (Typical) Antipsychotics I
Pr - chlorpromazine (Thorazine)
MOA - Strong blockade alpha adrenergic receptors, weak blockade cholinergic receptors
PU - relief of schizophrenia, control mania schizoaffective
AE - dizziness, drowsiness, orthostatic hypotension, extrapyramidal
Conventional (Typical) Antipsychotics II
Pr - haloperidol (Haldol)
MOA - butyrophenone
PU - acute and chronic psychotic disorders, tourette's, children with severe behavior problems
AE - Extrapyramidal side effects
Atypical Antipsychotics
Pr - clozapine (Clozaril)
MOA - interferes with binding of dopamine to receptor in limbic system
PU - range of psychotic symptoms, i.e. delusions, paranoia, irrational behavior
AE - INCREASED BLOOD GLUCOSE, dizziness, drowsiness, headache, constipation, transient fever, salivation, flu-like symptoms, tachycardia
Opioid Agonists
Pr - morphine (Astramorph PF, Duramorph, etc.)
MOA - bind with mu and kappa receptor sites to produce profound analgesia
PU - relief of pain after nonnarcotics have failed, preanesthetic medications, relieve shortness of breath, acute chest pain assoc. with MI
AE - dysphoria (restlessness, depression, anxiety), hallucinations, nausea, constipation, dizziness, itching sensation
OD = severe respiratory distress, cardiac arrest (naloxone = antidote)
Opioid Antagonists
Pr - naloxone (Narcan)
MOA - blocks mu and kappa receptors
PU - reversal of opioid effects, adjunctive therapy to reverse hyptension caused by septic shock
AE - minimal toxicity, reversal of opioid may result in loss of analgesia, increased BP, tremors, hyperventilation, nausea and vomiting, drowsiness
Nonopioid Analgesics
Pr - aspirin (acetylsalicylic acid, ASA)
MOA - inhibits prostaglandin synthesis involved in pain and inflammation and produces mild to mod relief of fever.
PU - anticoagulant, vasodilates peripheral blood vessels
AE - severe inflammatory disorders, gastric discomfort and bleeding, increased bleed time
Pr - sumatriptan (Imitrex)
MOA - vasoconstriction of cranial arteries (does not affect overall BP)
PU - antimigraine
AE - dizziness, drowsiness, warming sensation--effects not enough to d/c therapy
Drugs for Parkinson's Disease I
Dopaminergic Agents
Pr - levodopa (Larodopa)
MOA - restores dopamine in extrapyramidal areas of brain
PU - Parkinson's
AE - orthostatic hypotension, uncontrolled/purposeless movements, loss of appetite, nausea, vomiting
Drugs for Parkinson's Disease II
Cholinergic Blockers
Pr - benztropine (Cogentin)
MOA - blocks excess cholinergic stimulation of neurons (autonomic action)
PU - Parkinson's, EPS from antipsychotic pharmacotherapy
AE - typical anticholinergic effects, i.e. dry mouth, constipation, tachycardia
OD - physostigmine salicylate antidote
Drugs for Alzheimer's
Acetylcholinesterase Inhibitors
Pr - donepezil (Aricept)
MOA - AchE inhibitor that enhances effects of acetylcholine in neurons in cerebral cortex
AE - vomiting, diarrhea, darkened urine, insomnia, syncope, depression, headache, irritability, muscle cramps, arthritis, bone fractures, headache, fatigue, chest pain, increased libido, hot flashes, urinary incontinence, dehydration, blurred vision
OD - antidote anticholinergics, i.e. atropine