Pharm Bacterial Protein Synthesis Inhibitors

Front 1

What are the four bacterial protein synthesis inhibitors?

Back 1

1. Aminoglycosides(P site)
2. Tetracyclines(A site)
3. Chloramphenicol(stop AA transfer)
4. Macrolides(Stop tRNA translocation)

BUY AT 30

Front 2

Name the five aminogylcosides and their excretion?

Back 2

1. Streptomycin

2. Gentamycin

3. Tobramycin

4. Amikacin

5. Neomycin

1. Water soluble = Renal excretion

Front 3

What is the spectrum of aminoglycosides?(2)

Back 3

1. Gram (-) Rods

2. Coming with PCN for Psuedomonas and Enterococci

Front 4

What is streptomycin the DOC for?

Back 4

1. Yersina pestis

2. Tularemia

Front 5

What is the toxicity of Aminoglycosides?

Back 5

1. Nephrotoxic

2. Ototoxic

3. NM blockade with muscle relaxants( dcr. Ach)

Front 6

What is the MOA of aminoglycosides?(2)

Back 6

1. Attacks the 30S ribosome

2. Causes protein misreads in bacteria

Front 7

Why do you give neomycin during hepatic encephalopathy?

Back 7

1. Give it orally to flush the guy flora and NH4+

Front 8

Name the three tetracyclines?

Back 8

1. Doxy(Liver)

2. Miro(kidney)

3. Demeclo(SIADH Tx)

Front 9

What organisms do the tetracyclins attack?(6)

Back 9

1. Chlamydia

2. Mycoplasma

3. Borrellia

4. H. Pylori

5. Brucella

6. Vibrio

Front 10

What is the PK of tetracylcins?

Back 10

1. Water soluble

2. Kidney excretion

Front 11

What is the toxicity of tetracylcins?(3)

Back 11

1. Chelators(Ca and Mg)

2. No pregnancy(bone malformation)

3. Phototoxic

Front 12

What is chloramphenicol?

Back 12

1. Broad spectrum

2. Very toxic

3. Backup for Salmonella and Rickettsia

4. Good CNS

5. Liver = Glucouronidation

6. p450 inhibitor

Front 13

What is the toxicity of chloramphenicol?

Back 13

1. Aplastic Anemia

2. Grey Baby Syndrome (no glucouronyl transferase)

Front 14

Name the three macrolides?

Back 14

1. Erythro(liver)

2. Azithro(kidney)

3. Clarithro(Liver)

Front 15

What are the organisms targeted by the macrolides?

Back 15

1. A Legion Camped and ate My Chlams

2. My "A" Legion Camped and ate My Chlams

3. Harry's Legion Camped and "A"te My Chlams

Front 16

What are the toxicities of the macrolides?(4)

Back 16

1. Pregnancy X

2. Reversibly Ototoxic

3. GI distress

4. Erythro sometimes JAUNDICE

Front 17

Describe Clindamycin?(4)

Back 17

1. MOA = 50S

2. Inhibits translocation

3. Narrow spectrum; Gram (+) cocci, no MRSA

4. Anaerobes

Front 18

What does Clindamycin also treat?

Back 18

1. Osteomyelitis

Front 19

What toxicity does Clindamycin have?

Back 19

1. Psuedomembranous Colitis