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27 Cards in this Set
- Front
- Back
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What is a choristoma? Hamartoma?
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Normal tissues in abnormal location
-Hamartoma= too much tissue in normal location |
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What is the clinical significance of an ectopic pancreas?
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No clinical significance
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What are 2 causes of pancreatic cysts? Clinical significance?
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1) Developmental
2) Acquired -Generally don't cause problems |
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When do you see signs of canine juvenile pancreatic atrophy? What are the pathologies?
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Maldigestion, malabsorption by end of first year of life
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What are 3 clinical signs of canine juvenile pancreatic atrophy?
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1) Steatorrhea
2) Polyphagia 3) Weight loss +/- Diabetes |
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What do they think is the cause of canine juvenile pancreatic atrophy?
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Early lesions are dominated by lymphocytes so think its an autoimmune disease
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Acute pancreatitis= __________.
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Acute pancreatic necrosis
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What dogs are predisposed to pancreatitis?
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Obese dogs greater than 2 years old, sometimes on high fat diets
-More frequent in females |
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What are 5 clinical signs of acute pancreatitis?
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1) Vomiting
2) Abdominal pain -VERY PAINFUL 3) Anorexia 4) Depression 5) Dehydration |
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What causes the damage to pancreas and adjacent tissue in animals with pancreatitis?
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Release and activation of pancreatic enzymes
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What is the most common mechanism of lesions related to pancreatitis?
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Damage acinar cell--> activation of trypsin from trypsinogen
-Death is usually from shock due to release of myocardial suppressive factors |
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What is a proposed pathophysiologic mechanism of acute pancreatitis?
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Insult-->
-Zymogen activation -Generation of inflammatory mediators -Ischemia ------> necrosis, apoptosis |
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Acute pancreatitis results in ______ and _______ in the pancreas and omentum.
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Hemorrhage & edema
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What is a distinct lesion of acute pancreatitis?
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Fibrinous peritonitis
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What are 6 lesions of acute pancreatitis?
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1) Hemorrhage & edema in pancreas & omentum
2) Chalky-white nodules of fat necrosis 3) Fibrinous adhesions of pancreas and mesentery and peritoneum 4) Foci of pancreatic necrosis 5) Vascular thrombosis 6) +/- Bile duct obstruction (depends on chronicity) |
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Death from acute pancreatitis is due to ________.
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Cardiovascular collapse
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What are 5 sequelae to acute pancreatitis?
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1) Severe vomiting
2) Hypotensive and vasoactive shock 3) DIC 4) Multi-organ dysfunction syndrome 5) Death |
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What is a distinct lesion of acute pancreatitis on necropsy?
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White chalky appearance=fat necrosis
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What is chronic pancreatitis?
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Atrophy of acinar tissue and replacement by fibrous tissue
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What are the disorders that result from chronic pancreatitis?
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Exocrine and endocrine insufficiency can lead to maldigestion syndrome and diabetes mellitus
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Connective tissue formation from chronic pancreatitis results in _______ and _________.
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Bile duct obstruction and cholangitis
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What are 3 types of pancreatic neoplasia?
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1) Nodular hyperplasia
-Old dogs, cats, cattle 2) Adenoma -Benign & rare 3) Adenocarcinoma |
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What is the clinical significance of pancreatic nodular hyperplasia?
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Nothing, clinically insignificant
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Pacinian corpuscles in the pancreas are only visible in ______.
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Cats
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What are the parasites of the pancreas?
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Flukes-cats- Eurytrema procyonis
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What kind of damage do flukes cause to the pancreas?
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Atrophy and fibrous replacement
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What animals can develop stones in the pancreas? What's the clinical significance?
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Bovine Pancreolithiasis
-No clinical significance |
