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10 Cards in this Set
- Front
- Back
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Define MCV |
mean corpuscular volume, size of RBCs |
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Define macrocytic vs microcytic |
Macrocytic = RBCs larger than normals, due to low folate Microcytic = RBCs smaller than normal, due to low iron |
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What are the properties/functions of Vit B12? |
-coenzyme in conversion of homocystein -> methionine using methyl from 5-methy tetrahydrofolate -Tetrahydrofolate important in nucleic acid synthesis, so DNA synthesis impaired as result. -Deficiency leads to demyelination via abnormal methione synthase activity |
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In what diet(s) is B12 deficiency more common? |
Vegans/vegetarians |
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What are sources of B12? |
Meat, eggs, milk + milk products |
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How does B12 deficiency contribute to cerebral atrophy? |
B12 important for methione synthase |
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What causes anemia |
Low folate |
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Describe the roles of each vitamin/nutrient |
Thiamin - carb metabolism B6 - Transfer of nitrogen groups for protein synthesis B12 - Odd chain fatty acid, myelination Niacin/riboflavin - NAD/NADH + FAD/FADH zinc - protein synthesis |
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What characteristics are associated w/ Vit C deficiency |
Scurvy, increased capillary fragility *associated with collagen synthesis |
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What are the causes of the following diseases? |
Obesity = excess nutrients Rickets = Vitamin D deficiency Wernickle-Korsakoff = Vit B1 Scurvy = Vit C |
