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238 Cards in this Set

  • Front
  • Back
When is the notochord produced?
3rd-4th week of development
What produces the notochord?
primitive pit portion of the primitive streak
What invaginates forming a neural groove with neural folds on either side?
neural plate
The neural folds move together and fuse forming what structure?
neural tube
The wall of the neural tube is what type of epithelium?
pseudostratified neuroepithelium
Where are neural crest cells located?
located dorsolaterally on either side of the neural tube
Neural crest cells in the nervous system form:
Cranial and spinal ganglia (pseudounipolar neurons)

Autonomic ganglia

Schwann cells
The pseudostratified neuroepithelial wall of the neural tube neuroblasts differentiate and undergo migration transforming the wall into three layers:
Ventricular or ependymal zone

Intermediate or mantle zone (future grey matter)

Marginal zone (future white matter)
Ventricular or ependymal zone forms:
Ependymal lining of the central canal
Intermediate or mantle zone (future grey matter) forms:
Neuroblasts (neurons)

Glioblasts (astrocytes and oligodendrocytes)
Marginal zone (future white matter) consists of:
Axons and dendrites from the intermediate zone along with glia
Longitudinal groove that forms on the lateral wall of the central canal
Sulcus limitans
Divides the neural tube into a dorsal (alar plate) and a ventral (basal plate).
Sulcus limitans
Intermediate zone will become the dorsal horn containing sensory or afferent neurons
Alar plate
Intermediate zone will become the ventral horn containing motor or efferent neurons
Basal plate
What cells directly innervate skeletal muscle?
Ventral horn cells (somatic motor neurons)
What cells synapse with postganglionic autonomic neurons (derived from neural crest cells) which innervate smooth and cardiac muscle
Lateral horn cells (visceral motor neurons or preganglionic autonomic neurons)
Ventral horn and lateral horn cells are myelinated by what type of cells?
Myelinated by Schwann cells (derived from neural crest cells)
What is formed by the joining of the dendritic processes of the pseudounipolar neurons and the axons of the somatic and visceral motor neurons?
Spinal nerves
Formed from condensing mesenchyme surrounding the developing CNS
meninges
The subarachnoid space develops between what two layers?
the pia mater and arachnoid
Myelin is formed by what in the CNS?
Oligodendrocytes
Myelin is formed by what in the PNS?
Schwann cells
What connects the conus medullaris to the coccyx?
The filum terminale
By the end of the fourth week of development there are three primary brain vesicles:
Forebrain (prosencephalon)

Midbrain (mesencephalon)

Hindbrain (rhombencephalon)
By the end of the fifth week there are five secondary brain vesicles:
Forebrain divides into a telencephalon and diencephalon

Midbrain stays the same

Hindbrain divides into a metencephalon and myelencephalon
Flexion of the brain occurs at what 2 points?
in the midbrain region as the cephalic or midbrain flexure

at the junction of the spinal cord and hindbrain as the cervical flexure
Unequal growth between the two flexures produces:
A pontine flexure which flexes the cranial portion of the brain back on itself
Cavities of telencephalic vesicles develop into what?
lateral ventricles
Three swellings develop in the lateral wall of each side of the diencephalon:
Epithalamus

Thalamus

Hypothalamus
The central canal forms the third ventricle in what region of the brain?
diencephalon
Optic vesicles develop which are the primordia of the retinae and optic nerves in what region of the brain?
diencephalon
The infundibulum which is the primordia of the posterior pituitary is located in what region of the brain?
diencephalon
This region undergoes less change than any other region of the brain
mesencephalon (midbrain)
The central canal forms the cerebral aqueduct in what region of the brain?
mesencephalon (midbrain)
The alar plates form the superior and inferior colliculi in what region of the brain?
mesencephalon (midbrain)
The basal plates form the red nucleus, oculomotor nucleus, trochlear nucleus, reticular nuclei, and substantia nigra in what region of the brain?
mesencephalon (midbrain)
What develops cranial to the pontine flexure?
metencephalon (pons)
The central canal forms part of the fourth ventricle in what region of the brain?
metencephalon (pons)
The alar plates form the cerebellum, vestibular nuclei, and sensory nuclei of the trigeminal nerve in what region of the brain?
metencephalon (pons)
The basal plates form some of the motor nuclei of cranial nerves in what region of the brain?
metencephalon (pons)
What develops caudal to the pontine flexure?
myelencephalon (medulla)
The cranial portion is flattened and the caudal portion resembles the spinal cord in what region of the brain?
myelencephalon (medulla)
The central canal of the cranial portion forms the posterior part of the fourth ventricle in what region of the brain?
myelencephalon (medulla)
The alar and basal plates of the cranial portion form some of the sensory and motor nuclei of cranial nerves in what region of the brain?
myelencephalon (medulla)
The alar plates of the caudal portion form the gracile and cuneate nuclei in what region of the brain?
myelencephalon (medulla)
Where is the insula of Reil located?
in the lateral sulcus
Where is the diencephalon located?
in the central core of the cerebrum
What is the diencephalon composed of?
thalamus

hypothalamus

subthalamus

epithalamus
What is the brainstem composed of?
midbrain

pons

medulla
What serves as a connection between spinal cord, diencephalon, and cerebrum (sensory and motor tracts)?
Brainstem
Contains cranial nerve nuclei
Brainstem
Attached to the dorsum of the brainstem
Cerebellum
Consists of outer gray matter (cortex), inner white matter, and cerebellar nuclei buried within the white matter
Cerebellum
Located in the central core of the cerebrum
Diencephalon
Derived from neural crest cells
Cranial ganglia and dorsal root ganglia
Marginal zone forms the grey matter of the telencephalon
neural tube
Exceeds that of the spinal cord
Growth of vertebral column
Formed from the alar plates of the metencephalon
cerebellum
Formed from the central canals of the telencephalic vesicles
Lateral ventricles
Derived from the pia mater and ependyma
Choroid plexus
Inferior surface of frontal lobe
Gyrus recti
Located in the frontal and parietal lobes
Cingulate gyrus
Divided into a supramarginal and angular gyrus
Inferior parietal lobule
Located on the medial aspect of the frontal and parietal lobes
Paracentral lobule
Interconnect adjacent gyri and lobes of the same hemisphere
Associated fibers
Separated from the putamen and globus pallidus
Caudate nucleus
Afferent and efferent fibers of the cerebral cortex
Projection fibers
Interconnect lobes of the two cerebral hemispheres
Commissural fibers
Cerebral peduncles
Ventral aspect of the midbrain
This area is involved with the precise individual muscle contractions in the performance of movement (movement execution).
primary motor cortex
involved with the sequencing and coordination of movement (programming).
premotor cortex
involved with the preparation for movement (planning).
supplemental motor cortex
involved with voluntary conjugate movement of the eyes
frontal eye fields
involved with the generation of the proper pattern of signals to the speech musculature for the production of meaningful speech
motor speech area
determines affective reactions to present situations based on past experiences, planning and execution, and personality and emotion.
Prefrontal Cortex
perception and localization of the somatosensory information
primary somatosensory cortex
This area functions in touch localization, which is the ability to name an object placed in the hand (stereognosis) or numbers drawn on the palm (graphesthesia), and in memory of the somesthetic environment and spatial awareness
somatosensory association cortex
This area functions in the ability to recognize the significance of sensory information and the differentiation of sensory stimuli, and the planning and programming necessary for the execution of purposeful movement
Sensory Association Cortex
this area functions in the recognition of the meaning of written words.
Language Area
The dominant temporal lobe plays a primary role in language functions and both lobes function in auditory reception.
Primary Auditory Cortex
This area on the non-dominant hemisphere is concerned with the interpretation of auditory information, such as tones, loudness, sound modulation, timing as in music and the recognition of sounds
Auditory Association Cortex
This area on the dominant hemisphere is Wernicke's area which is involved in understanding and formulating coherent speech
Auditory Association Cortex
functions in the reception of odors
Primary Olfactory Cortex
This area functions in the identification of odors
Olfactory Association Cortex
This area functions in visual reception
Primary Visual Cortex
This area is involved with the recognition of objects, perception of color and depth, and other complex aspects of vision.
Visual Association Cortex
These are fibers to and from the cortex and other areas within the brain and the spinal cord
Projection fibers
Function in relaying sensory and motor information to and from the cortex
Corona radiata and internal capsule
The internal capsule is divided into an anterior limb, genu, and posterior limb
Corona radiata and internal capsule
These are efferent fibers from the hippocampal formation to the hypothalamus
Fornix
These are fibers that interconnect various regions of the same hemisphere
Association fibers
These type of fibers interconnect adjacent gyri
Short association fibers
function in higher brain activities such as language (eg. reading aloud).
Association fibers
These fibers interconnect corresponding lobes of the two cerebral hemispheres
Commissural fibers
These fibers let each cerebral hemisphere know what the other is doing and participate in cerebral dominancy
Commissural fibers
Interconnects all lobes and consists of: rostrum, genu, body, and splenium
Corpus callosum
Located within the white matter of the cerebrum
Subcortical nuclei
Function in postural control, maintenance of equilibrium, and eye movements
Vestibulocerebellum or flocculonodular lobe
Function in repetitive movements such as walking and scratching
Spinocerebellum or vermal and paravermal regions
Cerebrocerebellum or lateral hemispheres
Function in the regulation of skilled and complex movements
Connects the cerebellum with the midbrain
Superior cerebellar peduncle
Connects the cerebellum with the pons
Middle cerebellar peduncle
Connects the cerebellum with the medulla
Inferior cerebellar peduncle
Located ventral to the thalamus on either side of the third ventricle
Hypothalamus
Functions in control of autonomic and endocrine activity
Hypothalamus
Located ventral to the thalamus
Subthalamus
Can only be viewed in a frontal section of the brain
Subthalamus
Contains the subthalamic nucleus which is part of the basal ganglia
Subthalamus
Largest component of the diencephalon
Thalamus
Composed of nuclei that relay information to the cerebral cortex
Thalamus
The medial and lateral geniculate bodies are located on the caudal aspect
Thalamus
Located on the dorsal surface of the diencephalon and forms part of the roof of the third ventricle
Epithalamus
The habenula, stria medullaris, and pineal gland are observed on the dorsal surface
Epithalamus
Carry mechanosensory, pain, and temperature information
General sensory afferents (General Somatic Afferent or GSA):
Carry special sensory information which relates the body to the external environment
Special sensory afferents (Special Somatic Afferent or SSA)
Carry general sensory information (pain, fullness of organ, chemoreceptors, baroreceptors) from visceral structures
General (General Visceral Afferent or GVA)
Carry special sensory information that has a bearing on visceral activity (taste and smell).
Special (Special Visceral Afferent or SVA)
Innervate skeletal muscle derived from somites
Somatic motor efferents (General Somatic Efferent or GSE)
Innervate skeletal muscle derived from branchial arches
Branchial motor efferents (Special Visceral Efferent or SVE)
Innervate smooth and cardiac muscle (cranial nerves only contain parasympathetic fibers)
Visceral motor efferents (General Visceral Efferent or GVE)
Olfactory
SVA
Optic
SSA
Occulomotor
GSE, GVE
Trochlear
GSE
Trigeminal
GSA, SVE
Abducens
GSE
Facial
GSA, SVA, SVE, GVE
Vestibulocochlear
SSA
Glossopharyngeal
GSA, GVA, SVA, SVE, GVE
Vagus
GSA, GVA, SVA, SVE, GVE
Spinal accessory
SVE
Hypoglossal
GSE
the only portion of the adult nervous system that retains a primitive segmental structure
spinal cord
where the dorsal rootlets enter
Dorsolateral (posterolateral) sulcus
Separates the fasciculus gracilis and fasciculus cuneatus (only present above T6)
Dorsal or posterior intermediate sulcus
Ventrolateral or anterolateral sulcus
where the ventral rootlets emerge
There roots represent afferent (sensory) information
Dorsal roots
These roots represent efferent (motor) information
ventral roots
forms the cauda equina
The dorsal and ventral roots from L2 and below
What rami innervates the deep muscles of the back and the skin overlying them?
Dorsal rami
What rami innervate the muscles of the superficial back, trunk, extremities, and neck and the skin of these regions?
Ventral rami
Only found from T1- L2 or L3
Lateral horn
Connect the gray matter from one side to the other and found throughout the spinal cord
Dorsal and ventral gray commissures
Located between the commisures, dorsal horn, ventral horn, and lateral horn; and found throughout the spinal cord
Intermediate zone
Somatic motor neurons that innervate skeletal muscle fibers (extrafusal)
Alpha motor neurons (ventral horn cells or lower motor neurons)
Somatic motor neurons that innervate intrafusal skeletal muscle fibers of a muscle spindle
Gamma motor neurons
Their axons leave the spinal cord through the ventral rootlets and terminate outside the CNS
Root neurons
Located in the ventral and lateral horns
Root neurons
Located in the intermediolateral nucleus and sacral autonomic nucleus
Preganglionic autonomic neurons (sympathetic and parasympathetic)
Visceral motor neurons that innervate smooth and cardiac muscle
Preganglionic autonomic neurons (sympathetic and parasympathetic)
Their axons terminate within the CNS
Column neurons
Found primarily in the dorsal horn and intermediate zone
Column neurons
What neurons participate in the formation of ascending sensory pathways?
Tract neurons
These neurons participate in local circuitry involving alpha motor neurons (reflexes), coordination between spinal cord segments, and coordination between sides of the spinal cord
Interneurons
Their axons remain on the same side and same segment of the spinal cord
Intrasegmental interneurons
They are interposed between dorsal root afferents, descending tracts, and the ventral horn cells
Intrasegmental interneurons
Their axons ascend and descend to neighboring segments of the spinal cord
Intersegmental interneurons
They are interposed between dorsal root afferents, descending tracts, and the ventral horn cells in different segment of the spinal cord
Intersegmental interneurons
Their axons proceed to the other side of the spinal cord
Commissural interneurons
Laminae I-VI form what?
dorsal horn
Lamina VII forms what?
intermediate zone
laminae VIII and IX forms what?
ventral horn
lamin X forms what?
gray commissures
What tracts project from the spinal cord to the thalamus and then to the cerebral cortex?
Ascending tracts
What tracts project from the spinal cord to the cerebellum?
Ascending tracts
What tracts project from the spinal cord to certain brainstem nuclei?
Ascending tracts
What tracts project from the cerebral cortex to brainstem nuclei and to the spinal cord?
Descending tracts
What tracts project from certain brainstem nuclei to the spinal cord?
Descending tracts
What tracts interconnect spinal cord levels?
Propriospinal tracts
What spinal cord level has a large amount of gray matter, and the ventral horn is enlarged for innervation of the lower extremities?
Lumbar
What spinal cord level has more gray matter than white matter, and the ventral horn is enlarged in the upper segments for innervation of the lower extremities?
Sacral
What spinal cord level has a small amount of gray matter, and the lateral horn is present?
Thoracic
What spinal cord level has is the largest, contains the most white matter, and the ventral horn is enlarged for innervation of the upper extremities?
Cervical
What type of connective tissue is the dura mater composed of?
Thick layer of dense irregular connective tissue
Where does the dura mater end?
It ends at the level of the second sacral vertebrae as the lumbar cistern
Formed when the dura mater splits or separates from the periosteum
Dural venous sinuses
Projections of the dura mater that form incomplete septa
Dural reflections
Median projection located in the longitudinal fissure
Falx cerebri
Median projection between the cerebellar hemispheres
Falx cerebelli
Transverse projection between the occipital lobes and the cerebellum
Tentorium cerebelli
Projection that forms a roof over the pituitary fossa (sella turcica) and has a hole in it for the infundibular stem of the pituitary
Diaphragma sella
Attaches anteriorly to the crista galli , and posteriorly to the internal occipital protuberance and tentorium cerebelli
Falx cerebri
Follows the contours of the dura mater in the cranial cavity and the vertebral canal
Arachnoid mater
Thin fibrous layer adhering to the dura mater with only a film of extracellular fluid in the subdural space
Arachnoid mater
function as one-way valves to transfer CSF from the subarachnoid space to the dural venous sinuses
arachnoid granulations
Thin layer that follows the contours of the brain and spinal cord
Pia mater
Forms the filum terminale at the conus medullaris
Pia mater
Where do the posterior spinal arteries run to?
spinal cord
Largest vascular supply to the cerebellum is by what arteries?
Posterior inferior cerebellar arteries
Where do the anterior spinal arteries run to?
spinal cord
Where do the medullary arteries run to?
medulla
Name the 4 branches of the vertebral artery
Posterior spinal arteries

Anterior spinal arteries

Posterior inferior cerebellar arteries

Medullary arteries
Where do the anterior inferior cerebellar arteries run to?
cerebellum
Where do the pontine arteries run to?
Pons
Where do the superior cerebellar arteries run to?
cerebellum
Where do the posterior cerebral arteries run to?
To the inferior surface of temporal lobe; posterior, medial and inferior surfaces of occipital lobe
Name the 4 branches of the basilar artery
Anterior inferior cerebellar arteries

Pontine arteries

Superior cerebellar arteries

Posterior cerebral arteries
Where do the middle cerebral arteries run to?
To the lateral surface of the frontal, parietal, temporal, and occipital lobes
Where do the anterior cerebral arteries run to?
To the medial and superior surfaces of the frontal and parietal lobes
What vein do the deep cerebral veins drain into?
Great vein of Galen
What 4 veins do the superficial cerebral veins drain into?
superior sagittal sinus

inferior sagittal sinus

transverse sinus

basal vein.
What sinus is located in the dura above the falx cerebri?
Superior sagittal sinus
What sinus flows from anterior to posterior into the confluence of sinuses and then into the right transverse sinus?
Superior sagittal sinus
What sinus is located in the free edge of the falx cerebri?
Inferior sagittal sinus
What sinus flows from anterior to posterior into the straight sinus?
Inferior sagittal sinus
What sinus is located in the attachment of the falx cerebri to the tentorium cerebelli?
Straight sinus
What sinus receives the inferior sagittal sinus and great cerebral vein and flows into the left transverse sinus?
Straight sinus
What sinus is located at the internal occipital protuberance and is the dilated posterior portion of the superior sagittal sinus?
Confluence of sinuses
What sinus flows primarily into the right transverse sinus but there is a communication with the left transverse sinus?
Confluence of sinuses
What sinus is located in the margin of the tentorium cerebelli that is attached to the cranial bones?
Transverse sinuses
What sinus flows into the sigmoid sinuses?
Transverse sinuses
What sinus leaves the tentorium cerebelli and flow into the internal jugular vein (jugular foramen)?
Sigmoid sinuses
What sinus is located on either side of the sella turcica, flows into the superior and inferior petrosal sinuses?
Cavernous sinuses
What sinuses flows into the transverse and sigmoid sinuses respectively?
Superior and inferior petrosal sinuses
What artery vascularizes the ventral white column, lateral white column, and gray matter except for the dorsal horns?
Anterior spinal arteries
What artery vascularizes the dorsal white columns and the dorsal horn of the gray matter?
Posterior spinal arteries
What is the largest of the radicular arteries and provides the majority of the vascular supply to the lumbosacral region of the spinal cord?
The great radicular artery (artery of Adamkiewicz)
What is the member of class Glycopeptide?
vancomycin
To what class does member vancomycin belong to?
Glycopeptide
What are the members of class Macrolides?
erythromycin

azithromycin

clarithromycin
To what class does member erythromycin belong to?
Macrolides
To what class does member azithromycin belong to?
Macrolides
To what class does member clarithromycin belong to?
Macrolides
What are the members of class Tetracyclines?
tetracycline

doxycycline
To what class does member tetracycline belong to?
Tetracyclines
To what class does member doxycycline belong to?
Tetracyclines
What is the member of class Oxazolidinones?
linezolid
To what class does member linezolid belong to?
Oxazolidinones
What is the most common antibiotic resistance mechanism for Beta-lactams?
Altered transpeptidases

beta-lactamases
What is the most common antibiotic resistance mechanism for Fluroquinolones?
altered DNA gyrase

or

topoisomerase IV
What is the most common antibiotic resistance mechanism for Aminoglycosides?
altered ribosomes

or

modifying enzymes
What is the most common antibiotic resistance mechanism for Macrolides?
methylating enzymes
What is the most common antibiotic resistance mechanism for Vancomycin?
altered cell walls with D-lactate

or

D-serine
What is the most common antibiotic resistance mechanism for sulfa/trimethorim?
new, drug resistant enzymes (not altered targets)
What is the most common antibiotic resistance mechanism for Chloramphenicol?
transacetylases
What is the most common antibiotic resistance mechanism for Tetracycline?
Efflux
What is the most common antibiotic resistance mechanism for Rifampin?
altered RNA polymerase