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30 Cards in this Set

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Name the four signs and symptoms of Parkinson’s

1 resting tremor


2 rigidity and flexed posture


3 retarded movement such as Bradykinesia & hypokinesia


4 loss of postural reflexes

Parkinson’s patient with vertigo gaze palsy, can’t look down or up

Progressive supranuclear palsy


PSP

Parkinson’s patient with autonomic insufficiency, dizzy spell, passing out , balance probs, orthostatic hypotension

Multi system atrophy or Shy-Drager

Parkinson’s patient with cerebellar signs, ataxia

OPCA


OLIVOPONTOCEREBELLAR ATROPY

Tardive dyskinesia


Which antipsychotics are less likely to cause this?


What is effective treatment?


What is G.I. medicine that might cause this? Treatment

Clozapine & quetiapine


Tx clonazepam


Reglan stop med

Hyperthermia, rigidity, diaphoresis, autonomic instability, and altered mental status with the risk of rhabdomyolysis induced renal failure

Neuroleptic malignant syndrome

Treatment for neuroleptic malignant syndrome

Dopamine agonist, such as bromocriptine or dantrolene, supportive therapy, may need intubation

What medications may cause neuroleptic malignant syndrome

NMS is an Unusual response to antipsychotics. Occasionally Reglan or promethazine can cause this. Syndrome can occur days weeks or months after treatment was started

Cause of hemifacial spasms

80% tortuous dilated basilar artery or Basilar dolichoectasia


Also consider MS or acoustic neuroma

What is the treatment for hemifacial spasms?

Carbamazepine gabapentin


Botox


Surgery To separate the facial nerve from direct contact with the basilar artery

Young or old PT


New onset sz


Personality chg or hallucinations


Temporal lobe hemorrhage & necrosis

Herpes encephalitis

Dx herpes encephalitis

HSV PCR CSF


RX acyclovir

Flaccid paralysis w encephalitis

West Nile

Dx PML

CSF JC virus PCR


Or brain bx

What med can cause PML

Natalizumab or Tysabri

Difficulty standing on toes


Ankle reflex preserved (absent in S1 radiculopathy)

Sciatica

Foot drop


E version and dorsiflexion weak

Peroneal n compression prox end of fibula

Bell’s palsy treatment

Look at house-brackmann grading system to determine steroid dose. Give prednisone 60 mg and an antiviral, protect the eye

Causes of Bell’s palsy

Idiopathic, HSV, varicella zoster, Lyme disease, acute HIV, parotid tumor, cerebral Pontine angle tumor

Bilateral Bell’s palsy

MS, Neurosarcoidosis Lyme dx

On forward gaze, if one eye is looking laterally and downward Can happen in diabetes

Diabetic third nerve palsy if pupils are normal


If pupils are dilated, this means third nerve compression, possible aneurysm

Findings of LP on Guillain-Barre also called AIDP Acute inflammatory demyelinating polyneuropathy

LP high protein normal cells

Tx Guillain-Barré syndrome

IVIG or. Plasma exchange

GBS which did not resolve in 8 weeks

CIDP

Hereditary neuropathy


Myelin poorly formed


High arched foot hammer toes

Charcot Marie tooth disease


EMG demyelinating


Progressive neuropathy since childhood

Acute thiamine deficiency

Wernickes encephalopathy

Give big dose thiamine IV

Pt w myasthenia gravis & enlarged thymoma

Take thymoma out!

What else should you consider in a patient with myasthenia gravis

Autoimmune disorders such as lupus, 30% of patients with MG have autoimmune thyroiditis

Treatment for MG


Testing

Symptomatic: Pyridostigmine which is a ACh inhibitor


Also steroids, cyclosporine to help spare steroids


ACh Receptor Ab

Classically after what type of infection Guillain-Barré syndrome develop?

Campylobacter, or other G.I. bug