Murphy 14 N305 Anticoagulants

Front 1

Anticoagulant, Antiplatelet, and Thrombolytics Drugs

Back 1

Here are the stages to Hemostasis:

Front 2

Stage 1—formation of platelet plug
Platelet aggregation

Back 2

Stage 2—coagulation
Intrinsic system
Extrinsic system

Front 3

Anticoagulants (e.g. Heparin and warfarin)

Drugs that disrupts the coagulation cascade
Most effective against venous thrombosis

Back 3

Antiplatelet drugs (e.g. Aspirin and clopidogrel)

Drugs that inhibit platelet aggregation
Most effective against arterial thrombosis

Front 4

Thrombolytic drugs (e.g. Streptokinase and tPA)

Drugs that promote the lysis of fibrin (dissolve clots)

Back 4

Now you know all of the backgrounds on the drugs we will be learning. Now, to go more in depth. Ready?

Front 5

Heparin ~Rapid-acting anticoagulant
Enhances activity of antithrombin

Back 5

Heparin's use:
Pulmonary embolism
Stroke evolving
*Prevention of vein thrombosis

Front 6

Heparin's Adverse Effects

Back 6

Heparin's Adverse Effects
Hemorrhage
Heparin-induced *thrombocytopenia
Hypersensitivity reactions

Front 7

Warfarin (Coumadin)
An Oral anticoagulant
What is it's MOA?

Back 7

Warfarin (Coumadin) MOA:
Antagonist of vitamin K
Decreases synthesis of clotting factors

Front 8

Warfarin (Coumadin) Use:
Long-term prevention of **venous thrombosis

Back 8

Warfarin (Coumadin) SE:
Hemorrhage (**Bleeding)
Multiple DDIs (possibly most of all drugs)
May increase/decrease anticoagulant effect
May promote bleeding

Front 9

Antiplatelet Drugs

Do you know what drugs are given?

Back 9

Aspirin [ASA] and Clopidogrel [Plavix]
(Decrease platelet aggregation)

Front 10

These Antiplatelet Drugs:
Prevent of **arterial thrombosis
Prevent of MI (Aspirin)

Back 10

Antiplatelet Drugs SE:
Risk of major ***GI bleeding

Front 11

Thrombolytic Drugs
Streptokinase and tPA
They dissolve CLOTS!

Back 11

Thrombolytic Drugs Uses:
Myocardial infarction
Deep vein thrombosis
Massive pulmonary emboli

Front 12

Thrombolytic Drugs Adverse effects:

Back 12

Thrombolytic Drugs Adverse effects:
Bleeding
Antibody production
Hypotension
Fever