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22 Cards in this Set

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1st line in acute gout attack

indomethacin or naproxen (NSAIDS)

probenicid

inhibits reabsorption of uric acid in PCT

complication of probenicid

can precipitate uric acid calculi

colchicin; MOA and when is it given

binds and stabilizes tubulin to inhibit microtubule polyperization inhibiting neutrophil chemotaxis; given for acute (2nd line) and for prophylaxis



order of drugs given for acute gout

1. NSAIDS 2. colchicine 3. glucocorticoids

uricase that catalyzes metab of uric acid to allantoin (more water soluble)

pegloticase

fexobustat

inhibits xanthine oxidase

prevents metabolism of purines (gout drug)

allopurinol

increase concentrations of what drugs when using allopurinol

6-MP and azathioprine (metabolized by xanthine oxidase)

reversibly inhibits COX2

celecoxib; so no corrosive effects on GI lining

clinical use of celecoxib

RA and osteoarthritis

complication of celecoxib

sulfa allergy

irreversible inhibits 2 enzymes, thus decreasing TXA2 and prostaglandin, increasing bleeding time

aspirin

low dose vs high dose aspirin

low dose: decrease platelet aggregation


high dose: anti-inflammatory (COX2 only comes out to play for inflammation)

causes respiratory alkalosis early, but transitions to mixed metabolic acidosis-resp alkalosis later in toxic amounts

aspirin

causes gastric ulceration and tinnitis

aspirin

reversible inhibits COX1 and 2

NSAIDS (vs aspirin which irreversible inhibits)


1. can lead to renal ischemia


2. can lead to acute renal failure

1. nsaids (prostaglandins dilate afferent renal arteriole)


2. aspirin

given to close PDA

nsaids (indomethacin)

alendronate

bisphosphonate (binds hydroxyapatite in bone to inhibit osteoclast activity)...anti-resorptive

toxicity of bisphosphonates (alendronate)

corrosive esophagitis, osteonecrosis of jaw

recombinant PTH analog given to increase osteoblast activity for osteoporosis

teriparatide