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22 Cards in this Set
- Front
- Back
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1st line in acute gout attack |
indomethacin or naproxen (NSAIDS) |
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probenicid |
inhibits reabsorption of uric acid in PCT |
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complication of probenicid |
can precipitate uric acid calculi |
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colchicin; MOA and when is it given |
binds and stabilizes tubulin to inhibit microtubule polyperization inhibiting neutrophil chemotaxis; given for acute (2nd line) and for prophylaxis |
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order of drugs given for acute gout |
1. NSAIDS 2. colchicine 3. glucocorticoids |
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uricase that catalyzes metab of uric acid to allantoin (more water soluble) |
pegloticase |
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fexobustat |
inhibits xanthine oxidase |
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prevents metabolism of purines (gout drug) |
allopurinol |
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increase concentrations of what drugs when using allopurinol |
6-MP and azathioprine (metabolized by xanthine oxidase) |
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reversibly inhibits COX2 |
celecoxib; so no corrosive effects on GI lining |
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clinical use of celecoxib |
RA and osteoarthritis |
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complication of celecoxib |
sulfa allergy |
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irreversible inhibits 2 enzymes, thus decreasing TXA2 and prostaglandin, increasing bleeding time |
aspirin |
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low dose vs high dose aspirin |
low dose: decrease platelet aggregation high dose: anti-inflammatory (COX2 only comes out to play for inflammation) |
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causes respiratory alkalosis early, but transitions to mixed metabolic acidosis-resp alkalosis later in toxic amounts |
aspirin |
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causes gastric ulceration and tinnitis |
aspirin |
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reversible inhibits COX1 and 2 |
NSAIDS (vs aspirin which irreversible inhibits)
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1. can lead to renal ischemia 2. can lead to acute renal failure |
1. nsaids (prostaglandins dilate afferent renal arteriole) 2. aspirin |
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given to close PDA |
nsaids (indomethacin) |
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alendronate |
bisphosphonate (binds hydroxyapatite in bone to inhibit osteoclast activity)...anti-resorptive |
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toxicity of bisphosphonates (alendronate) |
corrosive esophagitis, osteonecrosis of jaw |
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recombinant PTH analog given to increase osteoblast activity for osteoporosis |
teriparatide |
