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14 Cards in this Set
- Front
- Back
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Other names for acute respiratory distress syndrome are: |
● Shock lung ● Acute lung injury ● Wet lung |
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Is ARDS usually bilateral or unilateral |
Bilateral/diffuse (almost always affects both lung) |
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ARDS is sudden/abrupt and progressive. T/F |
True |
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Is there alveolar capillary damage in ARDS |
Yes there is, and it's diffuse (widespread) That's why the lung is with extra excessive fluid. |
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What is hyaline membrane in lungs |
It is a composite of cellular debris, RBCs, protein, and other exudate (that flow into alveoli following damage of alveolar capillary membrane) that line the inner layer of the alveoli, making gas exchange difficult |
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Does ARDS usually resolve itself, just like pneumonia |
No, resolution is usual (because of large amount of alveolar damage/necrosis that usually occur) |
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Mention the stages of ARDS |
● Acute/Exudative phase (exudates and cells in alveolar, edema, congestion due to damage to alveolar capillary membrane) ● Proliferation/organizing phase (proliferation of fibroblasts and type 2 pneumocytes to restore damaged alveolar epithelium) ● Fibrotic phase (fibrosis due to vacuums in the alveolar tissue) |
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What factor that when released sustains pro-inflammatory state that causes ARDS |
Macrophage migration Inhibitory Factor (MIF) |
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Do cytokines release from activated alveolar-macrophages also cause vascular endothelial damage apart from recruiting cells ? |
Yes they cause vascular endothelial damage. |
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A characteristic feature of ARDS is |
Hyaline membrane |
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Examples of fibrogenic agents are |
● Transforming growth factor- beta (TGFB) ● Platelet derived growth factor (PDGF) |
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Mortality rate of ARDS is |
60% mortality |
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Prognosis of ARDS |
Poor prognosis, the worst in smokers and alcoholics (because apart from severe lung damage, a lot of issues might erupt apart from the smoking activity) |
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Damaged pneumocytes of alveolar can be generated from what airway cells? |
Bronchiolar stem cells (if not fibrosis) |
