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12 Cards in this Set
- Front
- Back
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What are three chemoattractants?
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1) N-formyl-methionyl peptides (FMLP)
2) C5a 3) Leukotriene B4 (LTB4) |
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What is cell mediated cytotoxicity (CMC)?
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The ability of a cell to lyse a target cell to which they are sufficiently closely bound
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Where are NK cells naturally present?
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Spleen and peripheral blood
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What common thing is seen in all ADCC cells?
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Fc receptor for IgG
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What does ADCC stand for? What cell types are involved?
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Antibody-dependent cell mediated cytotoxicity
K cells; some NK cells; some Tc cells; monocytes; neutrophils |
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What must be present for perforin to kill a cell? What does it do?
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Ca2+; it makes perforin polymerize and kill the cell by puncturing it
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True or false: the perforin CMC mechanism takes the longest amount of time
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False; the TNF/INF mechanism takes the longest
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What is delayed-type hypersensitivity (DTH)?
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A form of CMI in which the ultimate effector cell is the activated macrophage
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What is our primary defense mechanism against intracellular bacteria?
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Delayed type hypsersensitivity (DHT)
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Clinically, what is one indicator of anergy?
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Loss of DHT responses to universally encountered antigens
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What can lead to the Schwartzmann reaction?
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Excessive release of cytokines, such as TNFalpha
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What basic mechanism creates a granuloma?
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Persistent antigen presence leads to continual release of cytokines; immune system cells collect and collect, creating a big structure. T cells and macrophage-like multinucleated cells accumulate
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