Khin: Soft Tissue Tumors And Tumor-Like Lesions

Front 1

SubQ level; found in mediastinum, retroperitoneum, bowel wall; encapsulated, compsed of mature adipose tissue

Back 1

Lipoma

Front 2

2nd MC sarc. in adults; deep soft tissue; thigh, retoperitoneum; lipoblasts in different grades of differentiation; poorly differentiated tumors; chromosomal abnormalities: translocation and ring chromosomes identified

Back 2

Liposarcoma

Front 3

Mobile, well defined nodule in subQ tissues; mainly limbs; similar to fibroblasts, myofibroblasts, histiocytes; aka dermatofibromas

Back 3

Benign Fibrous Histiocytoma

Front 4

Extremities, ab. cavity, retroperitoneum + other sites; Lobulated, fleshy, infiltrating tumors w/ areas of hemorrhaging and necrosis; Histo: pleomorphic anaplastic spindle cells; storiform pattern w/ tumor giant cells and abnormal mitoses; metastesis is mainly through the blood to the lungs

Back 4

Malignant Fibrous Histiocytoma (aka Pleomorphic Spindle Cell Carcinoma)

Front 5

around teeth, in ovaries; well-defined gray masses; mature fibrous tissue

Back 5

Fibroma

Front 6

deep soft tissue; thigh; gray soft, fish-flesh infiltrating large masses w/ spindle cell growth w/ anaplasia and other features of malignancy; Herringbone pattern

Back 6

Fibrosarcoma

Front 7

rare, benign tumor of skel. musc; mature skel musc.; tongue, heart, tuberous sclerosis (mutationsin chroms. 9 or 16; benign tumors in the brain, heart, kidney, retina, and skin; seizures, mental retardation, s/s of other lesions)

Back 7

Rhabdomyoma

Front 8

Rhabdomyomas in the brain present as

Back 8

Cortical tubers and subependymal hamartomas

Front 9

MC soft tissue sarc. in children and young adults; immunohistochemical evidence of skel. musc. (biomarkers: actin, desmin, and myogenin)

Back 9

Rhabdosarcoma

Front 10

head and neck (orbit, nasophar., mid. ear) also in retoperitoneum, UG tract; sheets of small round cells

Back 10

Embryonal Rhabdosarcoma

Front 11

GU, biliary, URT; young children; polypoid, soft, grape-like appearance; undifferentiated rhabdosarcoma in myxoid tissue

Back 11

Botryoid Rhabdosarcoma

Front 12

Occur in extremities; undifferentiated rhabdomyoblasts in alveolar or pseudoglandular arrangement

Back 12

Alveolar Rhabdosarcoma

Front 13

Adult >45 y/o; mostly mm. of lower limbs; Large, atypical tumor cells, resemble pleomorphic spindle cells; highly malignant, but respond to chemo

Back 13

Pleomorphic Rhabdosarcoma

Front 14

Diabetics, alcoholics, and epileptics, APC gene mutation carriers, and those with familial adenomatous polyposis have an increased incidence of

Back 14

Fibromatosis

Front 15

Usually 2ndary to trauma, reactive cell prolif.; adults; small masses 1ly in extremities showing rapid growth; fibroblasts in loose myxoid backgroiund; enlarged nuclei, mitosis, NO ANAPHASE features; recurrence after excision is UNcommon

Back 15

Nodular Fasciitis

Front 16

Circumscribed, non-encapsulated mass w/in muscle, ususally extremities (quads); proliferated bibroblasts in myxoid stroma, associated w/ cartilage and bone formation; Usually the result of trauma, and areas of hemorrhages may also be present

Back 16

Traumatic Myositis Ossificans

Front 17

Low grade fibrosarcoma, usually locally invasive; DOES NOT METASTASIZE

Back 17

Fibromatosis (Desmoid tumor/Aggressive Fibromatosis)

Front 18

affects mothers in the perinatal period

Back 18

Abdominal Fibromatosis

Front 19

Which type of Fibromatosis affects Men and Women equally?

Back 19

Extra-abdominal Fibromatosis

Front 20

may be associated with Gardner's syndrome (=familial adenomatous polyposis, multiple osteomas, desmoid tumors)

Back 20

Intra-abdominal Fibromatosis

Front 21

Characteristics of fibromatosis

Back 21

invades surrounding tissues, non-encapsulated exuberant fibroproliferative lesions

Front 22

Presentation of fibromatosis

Back 22

fibrous overgrowth infiltrates masses in ant. ab. wall (mainly in females), neck, shoulder ares, and pelvic girdle area

Front 23

Gross appearance of Fibromatosis

Back 23

White, sarcoma-like tumor

Front 24

Histological appearance of Fibromatosis

Back 24

bands of fibrocytes and collagenous tissue

Front 25

Dapuytren Contracture

Back 25

a special form of fibromatosis found on palms of hands

Front 26

Peyronie Disease

Back 26

Special form of fibromatosis found on the penis