Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key


Play button


Play button




Click to flip

17 Cards in this Set

  • Front
  • Back
Describe the T cell receptor
A transmembrane receptor that is obligatorily associated with the CD3 complex. CD3 functions as the signal transducing unit
What are the two different types of MHC molecules, and what are they associated with
MHC I, associated with CD8+
MHC II, associated with CD4+
What was the MHC first associated with
Rapid rejection of tissue transplants
What is another name for the MHC
Human leukocyte antigens (HLAs)
Which genes are the most polymorphic genes in the genome of mammals
MHC genes
What are the three MHC I genes
What are the three MHC II genes
What is the structure of MHC I
MHC-encoded alpha chain and a non-MHC encoded subunit, B2-microglobulin. The alpha chain has a1 and a2 polymorphic domains, and a3 segement that binds CD8
What is the structure of MHC II
An alpha chain and B chain. a1 and B1 form the peptide binding cleft, and nonpolymorphic B2 binds CD4
Which pathway uses MHC I
Endogenous, for antigens found in the cytosol. Includes viruses and other intracellular pathogens. Found in all nucleated cells
How are cytosolic proteins targeted for degradation
Covalent addition of ubiquitin, which leads it to a proteasome
Which pathway uses MHC II
The exogenous pathway, for antigens outside the cell. Used only by professionals, such as dendritic cells, macrophages, and B cells
What stabilizes the MHC II molecules during lysosomal fusion
CLIP, which will be replaced by the peptide
What do MHC molecules bind
Both foreign and self peptides
What good are polymorphisms
They increase both the variety of peptides that are recognized and the variety of TCRs that can bind
What stabilizes the TCR/MHC-peptide interaction
CD8 or CD4
Why do extensive polymorphisms exist
To counter evasive strategies of pathogens