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31 Cards in this Set
- Front
- Back
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Bell cell activation requires ....
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Cross linking of surface immunoglobulin
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What receptors are on a B cell that bind to an antigen?
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IgM
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What are the 3 types of receptor associated tyrosine kinase?
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Blk, Fyn, & lyn
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What is the purpose of blk Fyn and lyn?
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They phosphorylate the immunoreceptor tyrosine based activation motifs (ITAMS)
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B cell Coreceptors are composed of 3 polypeptide chains which are
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CD19, CD81, and CR2
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What does CD19 do?
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Signals
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What does CR2 do?
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Binds to complement on the pathogen surface
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T or f: an antibody response needs tcell help
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False
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How do T1-2 antigens stimulate B-cell proliferation?
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By activating densely cross-link B cell receptors and Coreceptors to generate a signal above the required level to stimulate B cell proliferation
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What is cognate interaction?
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When t and B cells recognize different epitope a on the same antigen
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What role do cytokines secreted by helper T cells have?
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They determine whether centrocytes differentiate into plasma cells or memory B cells
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what do helper T cells need to secrete to create a plasma cell?
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IL-10
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Why does a helper T cell need to secrete to create a memory B cell?
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IL-4
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Which antibodies protect the internal tissues of the body?
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IgM IgG IgA
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What protects the mucosal surfaces of the body?
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Dimeric IgA
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What antibody is provided to a fetus via the mother and how?
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IgG via FcRn into the placenta
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Which antibodies are provided to the infant after birth and how?
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Dimeric IgA via breast milk
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What antibody isotypes are most effective at activating complement cascade?
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IgM and IgG3
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What is the function of erythrocyte CR1?
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Helps clear immune complexes from circulation. Transports them to the liver and spleen
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What distinguishes the 4 subgroups of IgG?
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The hinges. Relative length & # of disulphide bonds
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Cognate interaction occurs in the _______
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T zone
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What is the function of Fc receptors?
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Trigger uptake and breakdown of antibody coated pathogens
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In thymus dependent antigens, what two signals together drive B cell proliferation and differentiation into plasma cells?
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Antigen receptor and a cognate helper T cell
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What is the function of CD40L on a tcell?
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Binds to CD40 on the bcell and aids in activation of the bcell
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What induces a tight interaction between a tcell and bcell?
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T cell LFA-1 and bcell ICAM-1
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Activated B cells undergo _____ & _____
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Somatic hypermutation & isotope switching
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What are centroblasts?
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Proliferating bcells in germinal centres
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What is the dark zone?
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Densely packed centroblasts
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What is the function of BCL-XL?
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Prevents apoptosis of centrocytes
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What is the difference between a resting bcell and a plasma cell?
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Bcells don't have specificity yet and can be altered. Plasma cells cannot go through hypermutation and its specificity cannot be changed
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What effect does IgE have on mast cell surfaces?
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Rapid release of mast cell granules containing inflammatory mediators
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