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12 Cards in this Set
- Front
- Back
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IgM antibodies are produce during an acute/chronic infection
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acute
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IgG antibodies persist for a many years/many days
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Many years
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Presence of IgM antibodies indicates past, resolved infection, normally leading to immunity. Or ongoing persistent infection (HIV, herpesvirus) T/F
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FALSE! IgG does that!
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Give examples of some potential congenital (Present from birth) infections
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Rubella, CMV
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Give an example of a virus that cannot be propagated in cell culture
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HepB and many of the gastroenteritis viruses
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Give the three techniques used to detect vial antigens in clinical samples
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Latex agglutination
Immunofluorescence ELISA |
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Detection of HepB surface antigen can be done by ELISA T/F
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T
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What are the two principles of viral diagnosis?
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Detection of the virus, or parts thereof
Detection of the immune response |
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The study of antigen/antibody reactions in vitro
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Serology
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What is the 'Cytopathic effect'?
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Degenerative changes in cells, especially in tissue culture, and may be associated with the multiplication of certain viruses.
If it affects, CPE negative, if it doesn't, CPE positve |
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What does 'point of care' mean?
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Care at the bedside, not a lab. Results are found out quickly when it is important, e.g. HIV infection
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What is the advantage of physical viral detection, rather than of antibody detection?
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An individual may be immunosuppressed, and not produce Ab, so an Ab-detection test would not show it up.
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