Histopathology - Female Genital Pathology

Front 1

HPV infect

Back 1

Squamous cells

Front 2

HPV and infection

Back 2

1.HPV can infect the squamous cells

2.Replication of HPV in cervix occurs in the maturing squamous cells and results in a cytopathic effect, “koilocytic atypia,” consisting of nuclear atypia and a cytoplasmic perinuclear halo.

Front 3

What is “koilocytic atypia ?

Back 3

A kiolocyte is a squamous cell that has undergone a number of structural changes, which occurs as a result of infection of the cell by human pappilloma virus

Front 4

What is the vulva

Back 4

The vulva is the external female genital and include;

1. The moist hair bearing skin.

2. And mucosa of in that region.

Front 5

Discuss bartholin duct cyst

1. Introduction

2. Incidence

3. Etiology

4. Morphology

Back 5

CYST: Bartholin duct cysts:

2. are relatively common, occur at all ages, and

3. result from obstruction of the duct by an inflammatory process.

4. The resulting cysts are lined by the Squamous or Transitional epithelium.

Front 6

List examples of benign exophytic vulvar lesions

Back 6

1. Condyloma acuminatum

2. Vulvar fibroepithelial polyp

3. Vulvar squamous papilloma

Front 7

Discuss Condyloma acuminatum

Back 7

Condyloma acuminatum :

1. Condylomata acuminata are sexually transmitted, benign lesions that have a distinct verrucous (wart-like) gross appearance .

2. Aetiology: Condylomata acuminata are caused by low oncogenic risk HPVs, principally types 6 and 11.

3. Site they occur - It can also occur on the penis, female genitalia, urethra, perianal areas, and rectum. 4. Morphology

Grossly: It appear as soft, tan, cauliflower-like masses that occasionally reach many centimeters in diameter.

Microscopy: It consists of branching, treelike cores of stroma covered by squamous epithelium with characteristic viral cytopathic changes referred to as koilocytic atypia (enlarged, atypical nuclei and cytoplasmic vacuolation). It also exhibits acanthosis and hyperkeratosis.

Front 8

Define the following

1. Condyloma acuminatum

2. Vulvar fibroepithelial polyp

3. Vulvar squamous papilloma

Etiology

Back 8

1. Condyloma acuminatum, a papillomavirus-induced lesion, also called a genital wart.

2. Vulvar fibroepithelial polyps, or skin tags, are similar to skin tags occurring elsewhere on the skin.

3. Vulvar squamous papillomas are benign exophytic proliferations covered by nonkeratinized squamous epithelium, which develop on vulvar mucosal surfaces and may be single or numerous (vulvar papillomatosis).

The etiology of fibroepithelial polyps and squamous papillomas is unknown

Front 9

Vulvar lesions

Back 9

Front 10

Atrophic thinning and hyperplastic thicken of vulvar epithelium

Back 10

1. Lichen sclerosus - atrophic thinning ...

2. Lichen simplex chronicus - hyperplastic thickening ...

Front 11

About VIN

1. means

2. Classify

Back 11

VIN : Characterized by disordered maturation and nuclear abnormalites of the squamous cells. i. HPV-related VIN;

A. VIN I

B. VIN II

C. VIN III(classic VIN Or Bowens disease)

ii. Non-HPV-related VIN (differentiated VIN or VIN simplex) Classic VIN is characterized by nuclear atypia of the squamous cells, increased mitoses, and lack of cellular maturation .

Front 12

Discuss classic VIN

1. definition

2. Incidence

3. Risk factors

Back 12

1. Define - Classic VIN is characterized by nuclear atypia of the squamous cells, increased mitoses, and lack of cellular maturation .

2. Incidence ; It most commonly occurs in reproductive-age women, and the

3. risk factors are the same as those associated with cervical squamous intraepithelial lesions (e.g., young age at first intercourse, multiple sexual partners, male partner with multiple sexual partners).

4. etiology - The majority of cases of classic VIN are positive for HPV 16, and less frequently for other high-risk HPV types, like HPV 18 or 31.

Front 13

Discuss differentiated VIN

1. Define

2. Etiology

Back 13

Differentiated VIN is

1. characterized by marked atypia of the basal layer of the squamous epithelium with apparently normal epithelial maturation and differentiation in the superfical layers, thus the designation “differentiated VIN.

2. The etiology of differentiated VIN is unknown.

Front 14

........ is the most common Histologic type of vulvar cancer

Back 14

Squamous cell carcinoma

Front 15

List examples of cyst in the vagina

Back 15

CYSTS :

1. Epithelial inclusion cyst

2. Müllerian cyst

3. Mesonephric (gartner duct) cyst