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11 Cards in this Set
- Front
- Back
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Kaposi Sarcoma is casused by ? |
HHV 8 - a herpes virus (human herpes virus) |
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Cool colors remind us that HHV 8 is a ___ virus |
DNA |
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AIDS and immunosuppressed associated with ______ _______. |
Kaposi Sarcoma |
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Kaposi characterized by ? |
Erythematous violatious lesions from the nose, extremities, and mucous membranes. May be present as a plaque, patch, macule, or even as a nodule. Arise from primative vasculature forming mesenchymal cells. Pathogenesis involves angiogenesis. Newly created blood vessels within the lesions cause the violacious color. (red hose... proliferation of vasculature) |
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How does kaposi sarcoma cause proliferation of vasculature? |
dysregulation of VEG-F (veg Fertilizer) |
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Lesions can also be found anywhere within the __ _____. Most common place is the _____ ______. |
GI tract. Hard Palate |
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HHV8 can also infect __ cells, and cause a __ cell lymphoma known as primary Effusion lymphoma. |
B cells! (archer releases arrows like b cells release abs) |
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Transmission of HHV8? |
sexual contact, which includes kissing, especially in men who have sex with men. |
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3 populations of people for whom index of suspision for kaposi sarcoma should be high: |
AIDS/immunocompromised, Elderly Russian men (lower extremity lesions), adults in africa have classic presentation with palatal lesions but in kids it can be fatal. |
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Kaposi sarcoma lesions most commonly confused with another lesion... |
Basilary angiomatosis - bartonella hensleae (which can be transmitted by cat scratches) - tiger To definitively determine the diff must look microscopically. Kaposi sarcoma - lymphocytic infiltrate (viral) Basilary angiomatosis has a neutrophilic infiltrate (bacteria) |
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Treatment? |
antiretroviral therapy if patient is HIV positive... the lesions should start to shrink if patient responds to therapy. |
