Hemo Final Exam 2

Front 1

Which of the following is associated with Chediak-Higashi syndrome?

Back 1

?

Front 2

Plasminogen deficiency is associated with

Back 2

?

Front 3

In combination, the PT and PTT test for the functionality of all coagulation factors EXCEPT

Back 3

actor XIII

Front 4

Aliquots of plasma with a prolonged PT and prolonged APTT are mixed with various ratios of patient plasma and normal plasma. All samples are incubated at 37 degrees C and tested at 10,30 and 60 minute intervals. The PT and APTT results on all of the mixtures are corrected. These results would indicate the presence of:

Back 4

?

Front 5

In a patient who presented with poor wound healing, the aPTT, PT, and platelet count were normal. The probable diagnosis would be

Back 5

?

Front 6

The following coagulation results were obtained on a newborn:

Reference Ranges

PT 12.8 sec 9.5-14.5 sec

APTT 34.5 sec 20-35 sec

Thrombin time 14.0 sec 9-13 sec

Fibrinogen 380 mg/dL 200-400 mg/dL

The results are most suggestive of:

Back 6

normal newborn results

Front 7

The function of Vitamin K is

Back 7

to carboxylate the glutamic acid residues on selected coagulation factors

Front 8

The metabolic product of the endothelial cells that helps to maintain the quiescent state of the platelet in the blood stream is

Back 8

prostacyclin

Front 9

As thrombin is generated to convert fibrinogen to fibrin, it also functions as a positive control factor by increasing the activity of the coagulation cascade. To produce more factor IXa, thrombin activates which coagulation factor which serves to convert IX to IXa?

Back 9

?

Front 10

A bleeding time is used to evaluate the activity of:

Back 10

Platelets

Front 11

Hereditary hemorrhagic telangiectasia is a characterized by defects in

Back 11

connective tissue

Front 12

The parent cell of the platelet is the

Back 12

megakaryocyte

Front 13

Which test would be expected to be normal in a patient with dysfibrinogemia?

Back 13

?

Front 14

TPO is primarily produced in the

Back 14

?

Front 15

he key element in the platelet membrane responsible for production of arachidonic acid is

Back 15

?

Front 16

Platelet to platelet adhesion is mediated by fibrinogen binding to

Back 16

GPIIb/IIIa (aka αIIbβ3)

Front 17

Bruising under the skin that is less that 3 mm in diameter is called

Back 17

?

Front 18

All of the following are classified as SERPINs EXCEPT

Back 18

?

Front 19

The anticoagulant of choice for most routine coagulation studies is

Back 19

sodium citrate

Front 20

The Philadelphia chromosome is

Back 20

?

Front 21

A patient has been taking aspirin regularly for arthritic pain. Which one of the following tests is most likely to be abnormal in this patient?

Back 21

?

Front 22

In order for activated factor X to convert prothrombin to thrombin, it requires all of the following EXCEPT

Back 22

Factor XIII

Front 23

The action of protein S is to

Back 23

stabilize activated protein C

Front 24

Many platelet receptors will bind collagen. The most important of these is

Back 24

?

Front 25

Which of the following initiates in vivo coagulation by activation of factor VII?

Back 25

Tissue factor

Front 26

Which of the following is NOT considered part of the hemostasis specimen collection rules:

Back 26

Clotted specimen

Front 27

Which of the following factors is found only in the extrinsic coagulation pathway?

Back 27

VII

Front 28

Lack of or diminished levels of δ-granular contents are known as

Back 28

storage pool disorders

Front 29

What is the correct ratio for blood to anticoagulant in the blue top tube used for coagulation studies?

Back 29

9:1

Front 30

The coagulation test that is a sensitive, early marker for liver disease is

Back 30

?

Front 31

The purpose of ADAMTS 13 on the EC surface is to

Back 31

?

Front 32

Aspirin prevents platelet aggregation by inhibiting the action of which enzyme?

Back 32

cyclooxygenase

Front 33

Which of the following is associated with Glanzmann's thrombasthenia?

Back 33

absence of clot retraction

Front 34

Cells involved in hemostasis are:

Back 34

thrombocytes

Front 35

In Gray platelet syndrome, the defect is in

Back 35

the alpha granules

Front 36

The accumulation of the BCR/ABL fusion protein in the cytoplasm results in

Back 36

loss of apoptotic ability

Front 37

Mutations in the GP Ibα, GPIbβ, or GP IX are categorized as

Back 37

?

Front 38

For a patient with dysfibrinogenemia, which of the following tests will be normal?

Back 38

?

Front 39

Which of the following statements is true in regard to Partial Thromboplastin Time (PTT) test:

Back 39

Monitors unfractionated heparin therapy

Front 40

Reticulated platelets

Back 40

are markedly larger than ordinary mature platelets and are produced in compensation for thrombocytopenia

Front 41

n the APTT test, the patient’s plasma is mixed with:

Back 41

Phospholipid and calcium

Front 42

A patient has been taking aspirin regularly for arthritic pain. Which one of the following tests is most likely to be abnormal in this patient?

Back 42

?

Front 43

The nurse calls and asks for help interpreting the coagulation studies. She says that the PT is abnormal and the PTT is abnormal and the ELISA for prothrombin is normal. What is the most likely factor deficiency?

Back 43

Factor X

Front 44

The serine protease inhibitor antithrombin neutralizes the action of

Back 44

thrombin, and factors IXa, Xa, XIa, and XIIa

Front 45

The normal platelet count is in the range of

Back 45

50 - 400 x 109/L

Front 46

Conformational change of the GpIIb/IIIa integrin and binding of fibrinogen among other proteins between platelets is called

Back 46

platelet aggregation

Front 47

Which of the following is Vitamin K dependent?

Back 47

Factor VII

Front 48

The action of activated protein C complexed with protein S is to

Back 48

inactivate Factor Va and Factor VIIIa

Front 49

Bleeding into a joint is called

Back 49

Hemarthroses

Front 50

Prothrombin is:

Back 50

a protein formed by the liver requiring the presence of vitamin K to be functional

Front 51

Which of the following is characteristic of Bernard-Soulier syndrome?

Back 51

giant platelets

Front 52

All of the following are considered one of the acquired bleeding disorders EXCEPT:

Back 52

Hemophilia A

Front 53

A manual platelet count is 200 x 103/uL (normal 150-450 x 103/uL). Standardized template bleeding time is 15 min (normal 4.5 +/- 1.5 min)

This indicates that:

Back 53

abnormal platelet function should be suspected

Front 54

One of the coagulation factors is involved in both clot formation and in platelet aggregation. That factor is

Back 54

Fibrinogen

Front 55

Small bioactive molecules such as ADP, ATP and serotonin are stored in the

Back 55

dense bodies or δ-granules

Front 56

Normal platelets have a circulating life span of approximately

Back 56

10 days

Front 57

The hormone that stimulates production of platelets is

Back 57

thrombopoietin

Front 58

In areas of high shear rate, the protein to which platelets adhere is

Back 58

von Willebrand factor

Front 59

In regard to Platelet Aggregometery method, all of the following statements are true EXCEPT:

Back 59

?

Front 60

Endothelial cells contribute to coagulation by all of the following mechanism EXCEPT

Back 60

?

Front 61

Petechia, epistaxis and gingival bleeding are most commonly associate with defects in which of the following?

Back 61

?'

Front 62

What reagents are used in the PT test?

Back 62

?

Front 63

Plasminogen is actived to plasmin in vivo by the action of which of the following?

Back 63

?

Front 64

Von Willebrand factor circulates in complex with which of the coagulation factors?

Back 64

Factor VIII

Front 65

What protein is the primary player in the inhibition of fibrinlysis?

Back 65

?

Front 66

The aPTT measures which of the following groups of coagulation factors?

Back 66

I, II, V, X, VIII, IX, XI, XII

Front 67

Thrombin, adenosine diphosphate, epinephrine and thromboxan A2 are all

Back 67

platelet agonists

Front 68

Platelet aggregation will occur with the end production of

Back 68

?