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50 Cards in this Set
- Front
- Back
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hemolytic anemia:
which bilirubin increased? clinical signs? |
unconjugated
jaundice and yellow sclarea |
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cold agglutins precipitated by what?
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mycoplasma
IgM mediated cold icream...mmm |
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what typically causes warm agglutins?
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SLE, lymphoma, drugs
IgG mediated. warm weather is ggggreat |
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Erythrocytosis (increased RBCs) can be seen with what cancer?
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renal cell carcinoma due to paraneoplastic syndrome with increased erythropoetin
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CML:
genes involved? |
t9:22. bcr-abl
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immune mediated destruction of platelets ?
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idiopathic thrombocytopenic purpura – destruction of platelets by the spleen. Will have increased megakaryocytes
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CD16+ lymphocytes?
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NK cells, which are not inducible and therefore would not be increased in number regardless of infection
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lacunar cells suggest what?
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nodular sclerosing variant of hodgkins disease.
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treatment of lead poisoning?
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Edentate calcium disodium (EDTA) is used parentally for the chelation of lead
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chronic congestive splenomegaly is associated with what condition?
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hepatic cirrhosis
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distinctive histologic finding in hodgkins lymphoma?
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reid-sternberg cell - owl eye nucleus
R-S cells can be found surrounded by mature lymphocytes, eosinophils, and neutrophils |
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reactive hyperplasia of the spleen seen with what conditions?
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Chronic inflammatory disorders (e.g. RA)
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sickle cell genetic mechanism?
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point mutation leading to substitution of valine for glutamate at the 6th position of the beta globin chain
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which form of leukemia, is characterized by pancytopenia rather than increased numbers of circulating cells
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hairy cell leukemia
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positive for tartrate-resistant acid phosphatase (TRAP)
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characteristic cells (which are not always hairy) of hairy cell leukemia
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haptoglobin:
function? increases or decreases in hemolysis? |
serum protein that binds free Hg in serum, forming a tight complex
decreases in hemolysis |
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organism associated with cat scratch disease?
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baronella hensalae
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the most common adult non-hodgkins lymphoma?
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-Follicular lymphoma (small cleaved B cell)
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t(14:18)
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bcl-2 expression
Follicular lymphoma (small cleaved B cell) |
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hematologic lab abnormalities seen in DIC
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prolonged PT and PTT, decreased platelets.
schistocytes (fragmented RBCs) are seen on peripheral blood smear. Often due to obstetric complications |
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thoracic duct drains the whole body except what area?
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right arm, the right side of the chest, and the right side of the head - drain into R lymphatic duct
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what important clinical finding is associated with B12 deficiency but not folate deficiency?
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neurologic problems
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t(15;17)
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seen in acute promyelocytic leukemia (M3) – proliferation of promyelocytes
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Stage IIIb hodgkins disease?
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III - – involvement of lymph nodes on both sides of diaphragm.
B - constitutional symptoms present |
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M3 leukemia?
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acute promyelocytic leukemia with auer rods
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PT and PTT in TTP?
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normal
TTP - decreased platelets, hemolytic anemia with neurologic symptoms |
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how can you differentiate DIC from TTP?
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coag tests. In both hemolysis is present, but the PT and PTT are prolonged only in DIC.
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how is HUS different from TTP
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mental status changes are not part of the clinical picture of HUS, but are in TTP
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nosebleeds indicate platelet or coag disorder?
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platelet
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Hemarthroses (bleeding into joints), easy bruisibility suggests what kind of disorder
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coagulation disorder, e.g. hemophilia
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thoracic duct drains the whole body except what area?
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right arm, the right side of the chest, and the right side of the head - drain into R lymphatic duct
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what important clinical finding is associated with B12 deficiency but not folate deficiency?
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neurologic problems
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t(15;17)
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seen in acute promyelocytic leukemia (M3) – proliferation of promyelocytes
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Stage IIIb hodgkins disease?
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III - – involvement of lymph nodes on both sides of diaphragm.
B - constitutional symptoms present |
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M3 leukemia?
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acute promyelocytic leukemia with auer rods
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PT and PTT in TTP?
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normal
TTP - decreased platelets, hemolytic anemia with neurologic symptoms |
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how can you differentiate DIC from TTP?
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coag tests. In both hemolysis is present, but the PT and PTT are prolonged only in DIC.
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how is HUS different from TTP
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mental status changes are not part of the clinical picture of HUS, but are in TTP
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nosebleeds indicate platelet or coag disorder?
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platelet
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Hemarthroses (bleeding into joints), easy bruisibility suggests what kind of disorder
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coagulation disorder, e.g. hemophilia
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thoracic duct drains the whole body except what area?
|
right arm, the right side of the chest, and the right side of the head - drain into R lymphatic duct
|
|
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what important clinical finding is associated with B12 deficiency but not folate deficiency?
|
neurologic problems
|
|
|
t(15;17)
|
seen in acute promyelocytic leukemia (M3) – proliferation of promyelocytes
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|
|
Stage IIIb hodgkins disease?
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III - – involvement of lymph nodes on both sides of diaphragm.
B - constitutional symptoms present |
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M3 leukemia?
|
acute promyelocytic leukemia with auer rods
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PT and PTT in TTP?
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normal
TTP - decreased platelets, hemolytic anemia with neurologic symptoms |
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how can you differentiate DIC from TTP?
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coag tests. In both hemolysis is present, but the PT and PTT are prolonged only in DIC.
|
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how is HUS different from TTP
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mental status changes are not part of the clinical picture of HUS, but are in TTP
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nosebleeds indicate platelet or coag disorder?
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platelet
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Hemarthroses (bleeding into joints), easy bruisibility suggests what kind of disorder
|
coagulation disorder, e.g. hemophilia
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