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14 Cards in this Set
- Front
- Back
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Hypocoagulability |
A condition whereby little or no blood clots are formed following damage of vessels and hemorrhage. |
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Causes of hypocoagulable states |
● Deficiency of clotting factors (eg Hemophilia) ● DIC ● Liver disease (no production of clotting factors) ● Renal diseases (excretion of clotting agents) |
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Do platelet adhesion and aggregation require calcium ions |
Yes, they do |
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Coagulation Inhibition proteins include |
● Protein C & S (Vit K dependent proteases) ● Antithrombin ● Tissue factor pathway Inhibitor ● Prostacyclin ● Plasminogen to plasmin inducers (to remove clot) |
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How do Protein C & S act to inhibit coagulation |
They act by binding factors 5 and 8 |
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Antithrombin acts by in acting which factors |
● Factors 2, 9,10,11,12 (esp. 2 and 10) ● Its action is increased by Heparin |
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In lab investigation, bleeding time helps to assess |
● Platelet count and function (platelet adhere and aggregate to form primary hemostatic plug that stops bleeding, if platelet is dysfunctional or inadequate, bleeding time will be longer) ● It is basically the time it takes for platelet plug to form |
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What is the normal bleeding time |
2-8 minutes |
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Prothrombin time is how long |
10-15 seconds |
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PTT is how long |
25 -40 seconds (PTT has more letters than PT, so it has higher time) |
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What is thrombin time? How long does it take |
● It is the time taken for thrombin to convert fibrinogen to fibrin. ● Usually takes 9-13 seconds |
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What causes bleeding disorders? |
● Vascular defects ● Platelets disorders ● Deficiency of clotting factors |
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How does splenomegaly or hypersplenism cause thrombocytopenia |
Since the spleen has platelet storage function, with splenomegaly or hypersplenism, the spleen takes up and stores more platelet than normal causing circulatory platelets to less than usual hence thrombocytopenia. |
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The most common type of Hemophilia is |
Hemophilia A (80-85% of all cases) |
